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This paper aims to address the challenge of data generation beyond the training data and proposes a framework for Structural Extrapolated Data GEneration (SEDGE) based on suitable assumptions on the underlying data-generating process. We…

Machine Learning · Computer Science 2026-05-15 Kun Zhang , Jiaqi Sun , Yiqing Li , Ignavier Ng , Namrata Deka , Shaoan Xie

Structural crack detection is a critical task for public safety as it helps in preventing potential structural failures that could endanger lives. Manual detection by inexperienced personnel can be slow, inconsistent, and prone to human…

Computer Vision and Pattern Recognition · Computer Science 2025-07-04 Subhasis Dasgupta , Jaydip Sen , Tuhina Halder

Deep learning is catalyzing a scientific revolution fueled by big data, accessible toolkits, and powerful computational resources, impacting many fields including protein structural modeling. Protein structural modeling, such as predicting…

Biomolecules · Quantitative Biology 2020-07-17 Wenhao Gao , Sai Pooja Mahajan , Jeremias Sulam , Jeffrey J. Gray

Streaming data pipelines remain challenging and expensive to build and maintain, despite significant advancements in stronger consistency, event time semantics, and SQL support over the last decade. Persistent obstacles continue to hinder…

The past decade's "cryoEM revolution" has produced exponential growth in high-resolution structural data through advances in cryogenic electron microscopy (cryoEM) and tomography (cryoET). Deep learning integration into structural…

Quantitative Methods · Quantitative Biology 2025-07-29 Brady K. Zhou , Jason J. Hu , Jane K. J. Lee , Z. Hong Zhou , Demetri Terzopoulos

An important aspect of astrophysical MHD turbulence research is developing diagnostics to connect simulations with the observable universe. Turbulent systems are by definition structurally complex in all fluid variables (density, velocity,…

Astrophysics · Physics 2007-05-23 Eve C. Ostriker

Shelf seas are important for carbon sequestration and carbon cycle, but shelf sea observations for carbon pools are often sparse, or highly uncertain. Alternative can be provided by reanalyses, but these are often expensive to run. We…

Quantitative Methods · Quantitative Biology 2025-09-15 Jozef Skakala

Convolutional Neural Networks (CNN) have been regarded as a capable class of models for visual recognition problems. Nevertheless, it is not trivial to develop generic and powerful network architectures, which requires significant efforts…

Computer Vision and Pattern Recognition · Computer Science 2019-09-24 Zhaofan Qiu , Ting Yao , Yiheng Zhang , Yongdong Zhang , Tao Mei

Nonlinear PDEs give rise to complex dynamics that are often difficult to analyze in state space due to their relatively large numbers of degrees of freedom, ill-conditioned operators, and changing spatial and parameter resolution…

Numerical Analysis · Mathematics 2026-05-26 Christopher M. Douglas , Pierre Jolivet

Sea ice harbours a rich community of well-adapted microorganisms that inhabit liquid micro-spaces where extreme conditions prevail. Currently at risk under climate change, the sea-ice microbiome holds mysteries about evolution of life on…

Atmospheric and Oceanic Physics · Physics 2026-01-13 Béatrice Lessard-Hamel , Marcel Babin , Simon Thibault

We introduce DiffFit, a differentiable algorithm for fitting protein atomistic structures into an experimental reconstructed Cryo-Electron Microscopy (cryo-EM) volume map. In structural biology, this process is necessary to…

Quantitative Methods · Quantitative Biology 2025-01-09 Deng Luo , Zainab Alsuwaykit , Dawar Khan , Ondřej Strnad , Tobias Isenberg , Ivan Viola

Cryo-electron microscopy (cryo-EM), the subject of the 2017 Nobel Prize in Chemistry, is a technology for determining the 3-D structure of macromolecules from many noisy 2-D projections of instances of these macromolecules, whose…

Computer Vision and Pattern Recognition · Computer Science 2020-04-22 Roy R. Lederman , Joakim Andén , Amit Singer

This chapter discusses the development and implementation of algorithms based on Equation-Free/Dynamic Data Driven Applications Systems (EF/DDDAS) protocols for the computer-assisted study of the bifurcation structure of complex dynamical…

Computational Engineering, Finance, and Science · Computer Science 2023-05-05 M. O. Williams , Y. M. Psarellis , D. Pozharskiy , C. Chong , F. Li , J. Yang , P. G. Kevrekidis , I. G. Kevrekidis

High-resolution structure determination by cryo-electron microscopy (cryo-EM) requires the accurate fitting of an atomic model into an experimental density map. Traditional refinement pipelines such as Phenix.real_space_refine and Rosetta…

Biomolecules · Quantitative Biology 2026-03-10 Fuyao Huang , Xiaozhu Yu , Kui Xu , Qiangfeng Cliff Zhang

The importance of effective detection is underscored by the fact that socialbots imitate human behavior to propagate misinformation, leading to an ongoing competition between socialbots and detectors. Despite the rapid advancement of…

Social and Information Networks · Computer Science 2023-12-14 Xianghua Zeng , Hao Peng , Angsheng Li

Hybrid modeling combining data-driven techniques and numerical methods is an emerging and promising research direction for efficient climate simulation. However, previous works lack practical platforms, making developing hybrid modeling a…

Atmospheric and Oceanic Physics · Physics 2022-09-20 Xin Wang , Wei Xue , Yilun Han , Guangwen Yang

We develop a Python-based open-source package to analyze the results stemming from ab initio molecular-dynamics simulations of fluids. The package is best suited for applications on natural systems, like silicate and oxide melts,…

Simulation of turbulent flows, especially at the edges of clouds in the atmosphere, is an inherently challenging task. Hitherto, the best possible computational method to perform such experiments is the Direct Numerical Simulation (DNS).…

Fluid Dynamics · Physics 2022-08-19 Moumita Bhowmik , Manmeet Singh , Suryachandra Rao , Souvik Paul

Understanding the fundamental mechanisms of sediment transport, particularly those during the formation and evolution of bedforms, is of critical scientific importance and has engineering relevance. Traditional approaches of sediment…

Fluid Dynamics · Physics 2016-06-22 Rui Sun , Heng Xiao

Computational and mathematical models rely heavily on estimated parameter values for model development. Identifiability analysis determines how well the parameters of a model can be estimated from experimental data. Identifiability analysis…

Quantitative Methods · Quantitative Biology 2021-02-12 Marissa Renardy , Denise Kirschner , Marisa Eisenberg