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A new statistical technique for constructing linear latent structure (LLS) models from available data, supported by well established theoretical results and an efficient algorithm, is presented. The method reduces the problem of estimating…

Statistics Theory · Mathematics 2007-06-13 I. Akushevich , M. Kovtun , A. I. Yashin , K. G. Manton

Motivation: Structural heterogeneity in single-particle cryo-electron microscopy (cryo-EM) data represents a major challenge for high-resolution structure determination. Unsupervised classification may serve as the first step in the…

Data Analysis, Statistics and Probability · Physics 2017-11-01 Jiayi Wu , Yong-Bei Ma , Charles Congdon , Bevin Brett , Shuobing Chen , Qi Ouyang , Youdong Mao

Time series classification is of significant importance in monitoring structural systems. In this work, we investigate the use of supervised machine learning classification algorithms on simulated data based on a physical system with two…

Machine Learning · Computer Science 2024-03-14 Ergys Çokaj , Halvor Snersrud Gustad , Andrea Leone , Per Thomas Moe , Lasse Moldestad

Automated analyses of the outcome of a simulation have been an important part of atomistic modeling since the early days, addressing the need of linking the behavior of individual atoms and the collective properties that are usually the…

Chemical Physics · Physics 2019-05-22 Michele Ceriotti

This paper explores the use of deep neural networks for semiparametric estimation of economic models of maximizing behavior in production or discrete choice. We argue that certain deep networks are particularly well suited as a…

Econometrics · Economics 2022-04-06 Konrad Menzel

We develop Structured-Knowledge-Informed Neural Networks (SKINNs), a unified estimation framework that embeds theoretical, simulated, previously learned, or cross-domain insights as differentiable constraints within flexible neural function…

Machine Learning · Statistics 2026-04-02 Yi Cao , Zexun Chen , Lin William Cong , Heqing Shi

Identifying a coupled dynamical system out of many plausible candidates, each of which could serve as the underlying generator of some observed measurements, is a profoundly ill posed problem that commonly arises when modelling real world…

Neurons and Cognition · Quantitative Biology 2019-09-17 Amirhossein Jafarian , Peter Zeidman , Vladimir Litvak , Karl Friston

Sea ice plays an important role in stabilising the Earth system. Yet, representing its dynamics remains a major challenge for models, as the underlying processes are scale-invariant and highly anisotropic. This poses a dilemma:…

Atmospheric and Oceanic Physics · Physics 2025-11-13 Tobias Sebastian Finn , Marc Bocquet , Pierre Rampal , Charlotte Durand , Flavia Porro , Alban Farchi , Alberto Carrassi

Denoising diffusion bridge models (DDBMs) are a powerful variant of diffusion models for interpolating between two arbitrary paired distributions given as endpoints. Despite their promising performance in tasks like image translation, DDBMs…

Machine Learning · Computer Science 2025-05-01 Kaiwen Zheng , Guande He , Jianfei Chen , Fan Bao , Jun Zhu

Although deep learning models perform remarkably well across a range of tasks such as language translation and object recognition, it remains unclear what high-level logic, if any, they follow. Understanding this logic may lead to more…

Databases · Computer Science 2019-01-08 Thibault Sellam , Kevin Lin , Ian Yiran Huang , Yiru Chen , Michelle Yang , Carl Vondrick , Eugene Wu

Dynamic Causal Modeling (DCM) is a Bayesian framework for inferring on hidden (latent) neuronal states, based on measurements of brain activity. Since its introduction in 2003 for functional magnetic resonance imaging data, DCM has been…

Quantitative Methods · Quantitative Biology 2021-04-08 Inês Pereira , Stefan Frässle , Jakob Heinzle , Dario Schöbi , Cao Tri Do , Moritz Gruber , Klaas E. Stephan

The recent rise of cryo-EM and X-ray high-throughput techniques is providing a wealth of new structures trapped in different conformations. Understanding how proteins transition between different conformers, and how they relate to each…

Biomolecules · Quantitative Biology 2018-03-20 Laura Orellana , Johan Gustavsson , Cathrine Bergh , Ozge Yoluk , Erik Lindahl

Existing segmentation models trained on a single medical imaging dataset often lack robustness when encountering unseen organs or tumors. Developing a robust model capable of identifying rare or novel tumor categories not present during…

Computer Vision and Pattern Recognition · Computer Science 2025-07-02 Rong Wu , Ziqi Chen , Liming Zhong , Heng Li , Hai Shu

This paper proposes a structure-aware decoding method based on large language models to address the difficulty of traditional approaches in maintaining both semantic integrity and structural consistency in nested and overlapping entity…

Computation and Language · Computer Science 2026-01-29 Zhimin Qiu , Di Wu , Feng Liu , Yuxiao Wang

Along with recent progress in structural biology and genome biology, structural dynamics of molecular systems including nucleic acids has attracted attention in the context of gene regulation. Structure-function relationship is an important…

Biomolecules · Quantitative Biology 2021-11-23 Takeru Kameda , Akinori Awazu , Yuichi Togashi

Structural analysis is a method for verifying equation-oriented models in the design of industrial systems. Existing structural analysis methods need flattening of the hierarchical models into an equation system for analysis. However, the…

Other Computer Science · Computer Science 2021-10-28 Chao Wang , Li Wan , Tifan Xiong , Yuanlong Xie , Shuting Wang , Jianwan Ding , Liping Chen

The propensity of water to remain in a metastable liquid state at temperatures below its equilibrium melting point holds significant potential for cryopreserving biological material such as tissues and organs. The benefits conferred are a…

Materials Science · Physics 2023-12-04 Anthony N. Consiglio , Yu Ouyang , Matthew J. Powell-Palm , Boris Rubinsky

In this work, we present a new web based HPC-cloud platform for automatic virtual towing tank analysis. It is well known that the design project of a new hull requires a continuous integration of shape hypothesis and hydrodynamics…

Distributed, Parallel, and Cluster Computing · Computer Science 2018-10-24 Raffaele Ponzini , Francesco Salvadore

Diffusion models have achieved remarkable success in high-fidelity image generation but remain computationally demanding due to their multi-step denoising process and large model sizes. Although prior work improves efficiency either by…

Computer Vision and Pattern Recognition · Computer Science 2026-03-06 Zongfang Liu , Shengkun Tang , Zongliang Wu , Xin Yuan , Zhiqiang Shen

State-of-the-art saliency prediction methods develop upon model architectures or loss functions; while training to generate one target saliency map. However, publicly available saliency prediction datasets can be utilized to create more…

Computer Vision and Pattern Recognition · Computer Science 2020-09-01 Sandeep Mishra , Oindrila Saha
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