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In molecular dynamics (MD) simulations, transitions between states are often rare events due to energy barriers that exceed the thermal temperature. Because of their infrequent occurrence and the huge number of degrees of freedom in…

Chemical Physics · Physics 2024-12-06 Tuğçe Gökdemir , Jakub Rydzewski

We consider a non local isoperimetric problem arising as the sharp interface limit of the Ohta-Kawasaki free energy introduced to model microphase separation of diblock copolymers. We perform a second order variational analysis that allows…

Analysis of PDEs · Mathematics 2013-07-24 Vesa Julin , Giovanni Pisante

The work explores a specific scenario for structural computational optimization based on the following elements: (a) a relaxed optimization setting considering the ersatz (bi-material) approximation, (b) a treatment based on a nonsmoothed…

Computational Engineering, Finance, and Science · Computer Science 2021-08-06 J. Oliver , D. Yago , J. Cante , O. Lloberas-Valls

Multi-view clustering (MVC) has emerged as a powerful technique for extracting valuable insights from data characterized by multiple perspectives or modalities. Despite significant advancements, existing MVC methods struggle with…

Artificial Intelligence · Computer Science 2024-12-24 Lijian Li

Metadynamics (MTD) is a very powerful technique to sample high-dimensional free energy landscapes, and due to its self-guiding property, the method has been successful in studying complex reactions and conformational changes. MTD sampling…

Computational Physics · Physics 2016-02-05 Shalini Awasthi , Venkat Kapil , Nisanth N. Nair

In order to efficiently explore the chemical space of all possible small molecules, a common approach is to compress the dimension of the system to facilitate downstream machine learning tasks. Towards this end, we present a data driven…

Biomolecules · Quantitative Biology 2024-01-23 Paula Mercurio , Di Liu

In this paper, we derive optimal L2- and H1-norm error estimates for a fully discrete convex-splitting decoupled finite element method (FEM) for the two-phase diffuse interface magnetohydrodynamics (MHD) system. We use the semi-implicit…

Numerical Analysis · Mathematics 2026-03-17 Ke Zhang , Haiyan Su

Efficient algorithms to generate candidate crystal structures with good stability properties can play a key role in data-driven materials discovery. Here we show that a crystal diffusion variational autoencoder (CDVAE) is capable of…

Materials Science · Physics 2022-11-18 Peder Lyngby , Kristian Sommer Thygesen

A variety of methods are developed for characterising the free energy landscapes of continuum, Landau-type free energy models. Using morphologies of lipid vesicles and a multistable liquid crystal device as examples, I show that the methods…

Soft Condensed Matter · Physics 2015-06-23 Halim Kusumaatmaja

The two-regime method (TRM) has been recently developed for optimizing stochastic reaction-diffusion simulations. It is a multiscale (hybrid) algorithm which uses stochastic reaction-diffusion models with different levels of detail in…

Quantitative Methods · Quantitative Biology 2013-04-22 Mark B. Flegg , S. Jonathan Chapman , Likun Zheng , Radek Erban

Linearized Coupled Cluster Doubles (LinCCD) often provides near-singular energies in small-gap systems that exhibit static correlation. This has been attributed to the lack of quadratic $T_2^2$ terms that typically balance out small energy…

Chemical Physics · Physics 2025-05-13 Kevin Carter-Fenk

Unitary coupled cluster (UCC), originally developed as a variational alternative to the popular traditional coupled cluster method, has seen a resurgence as a functional form for use on quantum computers. However, the number of excitors…

Chemical Physics · Physics 2021-01-07 Maria-Andreea Filip , Alex J. W. Thom

Cryo-electron microscopy (cryo-EM) extracts single-particle density projections of individual biomolecules. Although cryo-EM is widely used for 3D reconstruction, due to its single-particle nature, it has the potential to provide…

The foundations of all methodologies for the measurement and verification (M&V) of energy savings are based on the same five key principles: accuracy, completeness, conservatism, consistency and transparency. The most widely accepted…

Artificial Intelligence · Computer Science 2018-01-26 Colm V. Gallagher , Kevin Leahy , Peter O'Donovan , Ken Bruton , Dominic T. J. O'Sullivan

A method is proposed for accurately describing arbitrary-shaped free boundaries in single-grid finite-difference schemes for elastodynamics, in a time-domain velocity-stress framework. The basic idea is as follows: fictitious values of the…

Classical Physics · Physics 2007-12-17 Bruno Lombard , Joël Piraux , Céline Gélis , Jean Virieux

A time-dependent vibrational electronic coupled-cluster (VECC) approach is proposed to simulate photoelectron/ UV-VIS absorption spectra, as well as time-dependent properties for non-adiabatic vibronic models, going beyond the…

Chemical Physics · Physics 2023-12-25 Songhao Bao , Neil Raymond , Marcel Nooijen

We propose two approaches for selecting variables in latent class analysis (i.e.,mixture model assuming within component independence), which is the common model-based clustering method for mixed data. The first approach consists in…

Computation · Statistics 2017-03-08 Matthieu Marbac , Mohammed Sedki

Two-dimensional CP**(N-1) models are used to compare the behavior of different cooling techniques on the lattice. Cooling is one of the most frequently used tools to study on the lattice the topological properties of the vacuum of a field…

High Energy Physics - Lattice · Physics 2008-11-26 B. Alles , L. Cosmai , M. D'Elia , A. Papa

We present a study of the two dimensional circular quantum dot model Hamiltonian using a range of quantum chemical ab initio methods. Ground and excited state energies are computed on different levels of perturbation theories including the…

Chemical Physics · Physics 2022-03-23 Faruk Salihbegović , Alejandro Gallo , Andreas Grüneis

One of the most pressing challenges in artificial intelligence is to make models more transparent to their users. Recently, explainable artificial intelligence has come up with numerous method to tackle this challenge. A promising avenue is…

Machine Learning · Computer Science 2025-09-30 Julia Wenkmann , Damien Garreau
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