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Single-cell perturbation prediction aims to infer how cells respond to unseen interventions and to achieve out-of-distribution (OOD) generalization, providing a computational route to understanding how perturbations reshape cellular…

Machine Learning · Computer Science 2026-05-26 Wenkang Jiang , Yuhang Liu , Erdun Gao , Ehsan Abbasnejad , Lina Yao , Javen Qinfeng Shi

In this note we present a generative model of natural images consisting of a deep hierarchy of layers of latent random variables, each of which follows a new type of distribution that we call rectified Gaussian. These rectified Gaussian…

Machine Learning · Statistics 2016-03-01 Tim Salimans

We present a novel framework for concomitant dimension reduction and clustering. This framework is based on a novel class of Bayesian clustering factor models. These models assume a factor model structure where the vectors of common factors…

Methodology · Statistics 2025-05-09 Hwasoo Shin , Marco A. R. Ferreira , Allison N. Tegge

We view disentanglement learning as discovering an underlying structure that equivariantly reflects the factorized variations shown in data. Traditionally, such a structure is fixed to be a vector space with data variations represented by…

Machine Learning · Computer Science 2021-06-08 Xinqi Zhu , Chang Xu , Dacheng Tao

We present new mechanisms for \emph{label differential privacy}, a relaxation of differentially private machine learning that only protects the privacy of the labels in the training set. Our mechanisms cluster the examples in the training…

Machine Learning · Computer Science 2021-10-06 Hossein Esfandiari , Vahab Mirrokni , Umar Syed , Sergei Vassilvitskii

We introduce an unsupervised clustering algorithm to improve training efficiency and accuracy in predicting energies using molecular-orbital-based machine learning (MOB-ML). This work determines clusters via the Gaussian mixture model (GMM)…

Chemical Physics · Physics 2023-03-28 Lixue Cheng , Jiace Sun , Thomas F. Miller

Generative approaches to clustering provide information on geometric properties of clusters, whereas discriminative approaches provide boundaries between clusters. Ideas from both approaches are incorporated to present a fully unsupervised,…

Machine Learning · Statistics 2026-04-28 Mackenzie R. Neal , Paul D. McNicholas , Arthur White

Variational inference techniques based on inducing variables provide an elegant framework for scalable posterior estimation in Gaussian process (GP) models. Besides enabling scalability, one of their main advantages over sparse…

Machine Learning · Statistics 2021-02-24 Simone Rossi , Markus Heinonen , Edwin V. Bonilla , Zheyang Shen , Maurizio Filippone

The generation of discontinuous distributions is a difficult task for most known frameworks such as generative autoencoders and generative adversarial networks. Generative non-invertible models are unable to accurately generate such…

Machine Learning · Computer Science 2021-12-20 Mariia Drozdova , Vitaliy Kinakh , Guillaume Quétant , Tobias Golling , Slava Voloshynovskiy

Gaussian Mixture Models (GMM) do not adapt well to curved and strongly nonlinear data. However, we can use Gaussians in the curvilinear coordinate systems to solve this problem. Moreover, such a solution allows for the adaptation of…

Computer Vision and Pattern Recognition · Computer Science 2023-04-05 Krzysztof Byrski , Przemysław Spurek , Jacek Tabor

Deep multi-view clustering incorporating graph learning has presented tremendous potential. Most methods encounter costly square time consumption w.r.t. data size. Theoretically, anchor-based graph learning can alleviate this limitation,…

Machine Learning · Computer Science 2025-04-15 Bocheng Wang , Chusheng Zeng , Mulin Chen , Xuelong Li

We consider a simulation optimization problem for a context-dependent decision-making. A Gaussian mixture model is proposed to capture the performance clustering phenomena of context-dependent designs. Under a Bayesian framework, we develop…

Methodology · Statistics 2020-12-15 Haidong Li , Henry Lam , Yijie Peng

Mixtures of Gaussian factors are powerful tools for modeling an unobserved heterogeneous population, offering - at the same time - dimension reduction and model-based clustering. Unfortunately, the high prevalence of spurious solutions and…

Methodology · Statistics 2016-08-08 L. A. García-Escudero , A. Gordaliza , F. Greselin , S. Ingrassia , A. Mayo-Iscar

Recent advances in generative AI offer promising solutions for synthetic data generation but often rely on large datasets for effective training. To address this limitation, we propose a novel generative model that learns from limited data…

Machine Learning · Statistics 2025-05-27 Michail Spitieris , Massimiliano Ruocco , Abdulmajid Murad , Alessandro Nocente

Deep reinforcement learning systems often suffer from unstable training dynamics due to non-stationarity, where learning objectives and data distributions evolve over time. We show that under non-stationary targets, isotropic Gaussian…

Machine Learning · Computer Science 2026-03-20 Ali Saheb Pasand , Johan Obando-Ceron , Aaron Courville , Pouya Bashivan , Pablo Samuel Castro

Clustering algorithms have wide applications and play an important role in data analysis fields including time series data analysis. However, in time series analysis, most of the algorithms used signal shape features or the initial value of…

Machine Learning · Statistics 2020-04-30 Daisuke Kaji , Kazuho Watanabe , Masahiro Kobayashi

Variational auto-encoders (VAEs) are a powerful approach to unsupervised learning. They enable scalable approximate posterior inference in latent-variable models using variational inference (VI). A VAE posits a variational family…

Machine Learning · Computer Science 2022-06-08 Samarth Sinha , Adji B. Dieng

Variational Autoencoders (VAEs) provide a flexible and scalable framework for non-linear dimensionality reduction. However, in application domains such as genomics where data sets are typically tabular and high-dimensional, a black-box…

Machine Learning · Statistics 2020-03-10 Kaspar Märtens , Christopher Yau

Dense conditional random fields (CRF) with Gaussian pairwise potentials have emerged as a popular framework for several computer vision applications such as stereo correspondence and semantic segmentation. By modeling long-range…

Computer Vision and Pattern Recognition · Computer Science 2016-08-23 Alban Desmaison , Rudy Bunel , Pushmeet Kohli , Philip H. S. Torr , M. Pawan Kumar

A clustered adaptive intervention (cAI) is a pre-specified sequence of decision rules that guides practitioners on how best - and based on which measures - to tailor cluster-level intervention to improve outcomes at the level of individuals…

Methodology · Statistics 2025-05-05 Yao Song , Kelly Speth , Amy Kilbourne , Andrew Quanbeck , Daniel Almirall , Lu Wang
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