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Major depressive disorder (MDD) is a prevalent mental disorder associated with complex neurobiological changes that cannot be fully captured using a single imaging modality. The use of multimodal magnetic resonance imaging (MRI) provides a…

Computer Vision and Pattern Recognition · Computer Science 2026-04-14 Nojod M. Alotaibi , Areej M. Alhothali

Major depressive disorder (MDD) is a common neuropsychiatric condition whose accurate diagnosis from resting-state functional magnetic resonance imaging (rs-fMRI) remains difficult. Dynamic functional connectivity (DFC) captures…

Computer Vision and Pattern Recognition · Computer Science 2026-05-26 Muhammad Asif Hasan , Yanming Zhu , Xuefei Yin , Alan Wee-Chung Liew

Emerging evidence showed that major depressive disorder (MDD) is associated with disruptions of brain structural and functional networks, rather than impairment of isolated brain region. Thus, connectome-based models capable of predicting…

Neurons and Cognition · Quantitative Biology 2021-10-18 Aya Kabbara , Gabriel Robert , Mohamad Khalil , Marc Verin , Pascal Benquet , Mahmoud Hassan

Depression is underdiagnosed in primary care, yet timely identification remains critical. Recorded clinical encounters, increasingly common with digital scribing technologies, present an opportunity to detect depression from naturalistic…

Computation and Language · Computer Science 2026-04-09 Feng Chen , Manas Bedmutha , Janice Sabin , Andrea Hartzler , Nadir Weibel , Trevor Cohen

Depression is a serious mental health illness that significantly affects an individual's well-being and quality of life, making early detection crucial for adequate care and treatment. Detecting depression is often difficult, as it is based…

Computer Vision and Pattern Recognition · Computer Science 2025-08-12 Md Rezwanul Haque , Md. Milon Islam , S M Taslim Uddin Raju , Hamdi Altaheri , Lobna Nassar , Fakhri Karray

Large Language Models (LLMs) have demonstrated remarkable success across diverse fields, establishing a powerful paradigm for complex information processing. This has inspired the integration of speech into LLM frameworks, often by…

Audio and Speech Processing · Electrical Eng. & Systems 2025-12-30 Xiangyu Zhang , Fuming Fang , Peng Gao , Bin Qin , Beena Ahmed , Julien Epps

Depression detection using vocal biomarkers is a highly researched area. Articulatory coordination features (ACFs) are developed based on the changes in neuromotor coordination due to psychomotor slowing, a key feature of Major Depressive…

Audio and Speech Processing · Electrical Eng. & Systems 2021-04-12 Nadee Seneviratne , Carol Espy-Wilson

Subjective cognitive decline (SCD) is a preclinical stage of Alzheimer's disease (AD) which occurs even before mild cognitive impairment (MCI). Progressive SCD will convert to MCI with the potential of further evolving to AD. Therefore,…

Computer Vision and Pattern Recognition · Computer Science 2023-02-17 Hao Guan , Ling Yue , Pew-Thian Yap , Shifu Xiao , Andrea Bozoki , Mingxia Liu

We describe the development of a model to detect user-level clinical depression based on a user's temporal social media posts. Our model uses a Depression Symptoms Detection (DSD) classifier, which is trained on the largest existing samples…

Computation and Language · Computer Science 2023-03-31 Nawshad Farruque , Randy Goebel , Sudhakar Sivapalan , Osmar R. Zaïane

By focusing on melancholic features with biological homogeneity, this study aimed to identify a small number of critical functional connections (FCs) that were specific only to the melancholic type of MDD. On the resting-state fMRI data,…

Depression is a widespread mental health disorder, and clinical interviews are the gold standard for assessment. However, their reliance on scarce professionals highlights the need for automated detection. Current systems mainly employ…

Computation and Language · Computer Science 2025-03-04 Linhai Zhang , Ziyang Gao , Deyu Zhou , Yulan He

Major depressive disorder (MDD) is one of the most common mental health conditions that has been intensively investigated for its association with brain atrophy and mortality. Recent studies reveal that the deviation between the predicted…

Neurons and Cognition · Quantitative Biology 2022-10-18 Yunsong Luo , Wenyu Chen , Jiang Qiu , Tao Jia

Individual's general well-being is greatly impacted by mental health conditions including depression and Post-Traumatic Stress Disorder (PTSD), underscoring the importance of early detection and precise diagnosis in order to facilitate…

Machine Learning · Computer Science 2025-02-07 Himanshi Singh , Sadhana Tiwari , Sonali Agarwal , Ritesh Chandra , Sanjay Kumar Sonbhadra , Vrijendra Singh

With more than 300 million people depressed worldwide, depression is a global problem. Due to access barriers such as social stigma, cost, and treatment availability, 60% of mentally-ill adults do not receive any mental health services.…

Computer Vision and Pattern Recognition · Computer Science 2018-11-28 Albert Haque , Michelle Guo , Adam S Miner , Li Fei-Fei

Objective: Voice disorders significantly compromise individuals' ability to speak in their daily lives. Without early diagnosis and treatment, these disorders may deteriorate drastically. Thus, automatic classification systems at home are…

Audio and Speech Processing · Electrical Eng. & Systems 2023-04-27 Heng-Cheng Kuo , Yu-Peng Hsieh , Huan-Hsin Tseng , Chi-Te Wang , Shih-Hau Fang , Yu Tsao

Background Major depressive disorder (MDD) is a leading cause of global disability, yet current diagnostic approaches often rely on subjective assessments and lack the ability to integrate multimodal clinical information. Large language…

Machine Learning · Computer Science 2025-09-30 Yuyang Sha , Hongxin Pan , Gang Luo , Caijuan Shi , Jing Wang , Kefeng Li

Recent progress has been made in detecting early stage dementia entirely through recordings of patient speech. Multimodal speech analysis methods were applied to the PROCESS challenge, which requires participants to use audio recordings of…

Audio and Speech Processing · Electrical Eng. & Systems 2025-02-14 Lei Chi , Arav Sharma , Ari Gebhardt , Joseph T. Colonel

Major Depressive Disorder (MDD), affecting millions worldwide, exhibits complex pathophysiology manifested through disrupted brain network dynamics. Although graph neural networks that leverage neuroimaging data have shown promise in…

Machine Learning · Computer Science 2025-11-25 Weidao Chen , Yuxiao Yang , Yueming Wang

Depression, a prevalent and serious mental health issue, affects approximately 3.8\% of the global population. Despite the existence of effective treatments, over 75\% of individuals in low- and middle-income countries remain untreated,…

Computation and Language · Computer Science 2024-07-19 Shengjie Li , Yinhao Xiao
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