Related papers: A Mechatronics view at nerve conduction
The generation of action potential brings into play specific mechanosensory stimuli manifest in the variation of membrane capacitance, resulting from the selective membrane permeability to ions exchanges and testifying to the central role…
It is suggested that the propagation of the action potential is accompanied by an axoplasmic pressure pulse propagating in the axoplasm along the axon length. The pressure pulse stretch-modulates voltage-gated Na (Nav) channels embedded in…
This work proposes a two-dimensional electrophysiological model for describing neuronal responses to external electric stimuli under patch-clamped conditions. Our proposed model successfully captures the key features of the Hodgkin-Huxley…
Complex fluids flow in complex ways in complex structures. Transport of water and various organic and inorganic molecules in the central nervous system are important in a wide range of biological and medical processes [C. Nicholson, and S.…
We suggest that the propagation of the action potential is driven by a pressure pulse propagating in the axoplasm along the axon length. The pressure pulse mechanically activates Na ion channels embedded in the axon membrane. This…
Here a viable and never before investigated mechanism of propagation of spikes along neurons is proposed. In the following, velocity of propagation of small-amplitude pressure waves through the cytoplasmic interior of myelinated and…
The Hodgkin-Huxley model of nerve pulse propagation relies on ion currents through specific resistors called ion channels. We discuss a number of classical thermodynamic findings on nerves that are not contained in this classical theory.…
Processes of propagation and interaction of nonlinear gravity-capillary waves on the free surface of a deep non-conducting liquid with high dielectric constant under the action of a tangential electric field are numerically simulated. The…
The physical mechanism on meridians (acupuncture lines) is studied and a theoretical model is proposed. The meridians are explained as an alternating system responsible for the integration and the regulation of life in addition to the…
The guiding and transport of energy, for example of electromagnetic waves underpins many technologies that have shaped modern society, ranging from long distance optical fibre telecommunications to on-chip optical processors. Traditionally,…
We investigate different mechanical effects which accompany the nerve pulse propagation by using mathematical modeling. The propagation process is composed by three connected phenomena: (i) the action potential (electrical signal) which is…
The Hodgkin-Huxley (HH) model is the currently accepted formalism of neuronal excitability. However, the HH model does not capture a number of biophysical behaviors associated with action potentials or propagating nerve impulses. Physical…
In the last fifteen years a debate emerged about the validity of the famous Hodgkin-Huxley model for nerve impulse. Mechanical models have been proposed. This note reviews the experimental properties of the nerve impulse and discusses the…
The dynamics of a spherical elastic capsule, containing a Newtonian fluid bounded by an elastic membrane and immersed in another Newtonian fluid, in a uniform DC electric field is investigated. Discontinuity of electrical properties such as…
Signals recorded from neurons with extracellular planar sensors have a wide range of waveforms and amplitudes. This variety is a result of different physical conditions affecting the ion currents through a cellular membrane. The…
This paper attempts to review our studies on the propagation of signals in nerves over the past decade. The need for interdisciplinary studies is stressed that helps to understand the physical mechanisms of coupling the electrical,…
The multi-cellular hydrodynamic interactions play a critical role in the phenomenology of blood flow in the microcirculation. A fast algorithm has been developed to simulate large numbers of cells modeled as elastic thin membranes. For red…
The dynamics of phase-separated interfaces shape the behavior of both passive and active condensates. While surface tension in equilibrium systems minimizes interface length, non-equilibrium fluxes can destabilize flat or constantly curved…
Endothelial cells are responsible for the formation of the capillary blood vessel network. We describe a system of endothelial cells by means of two-dimensional molecular dynamics simulations of point-like particles. Cells' motion is…
Trans-membrane gradients and fluxes of cations (H+, Na+, K+, etc.) were deemed to be the rationale of electrical activities of aerobic cells/organelles, as per classical perceptions. Murburn concept (an umbrella of theorization based in…