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This paper proposes the use of Eukaryotic cells, namely astrocytes, to develop logic gates. The logic gates are achieved by manipulating the threshold of Ca$^{2+}$ ion flows between the cells, based on the input signals. Through wet-lab…

Biocomputing technologies exploit biological communication mechanisms involving cell-cell signal propagation to perform computations. Researchers recently worked toward realising logic gates made by neurons to develop novel devices such as…

Emerging Technologies · Computer Science 2022-09-07 Giulio Basso , Michael Taynnan Barros

With conventional silicon-based computing approaching its physical and efficiency limits, biocomputing emerges as a promising alternative. This approach utilises biomaterials such as DNA and neurons as an interesting alternative to data…

Emerging Technologies · Computer Science 2024-08-15 Giulio Basso , Reinhold Scherer , Michael Taynnan Barros

The potential of synthetic biology techniques for designing complex cellular circuits able to solve complicated computations opens a whole domain of exploration, beyond experiments and theory. Such cellular circuits could be used to carry…

Neurons and Cognition · Quantitative Biology 2013-10-21 Luís F. Seoane , Ricard V. Solé

Artificial neurons built on synthetic gene networks have potential applications ranging from complex cellular decision-making to bioreactor regulation. Furthermore, due to the high information throughput of natural systems, it provides an…

Neural and Evolutionary Computing · Computer Science 2020-01-31 Sihao Huang

One of the most interesting and still growing scientific fields is neuromorphic engineering, which is focused on studying and designing hardware and software with the purpose of mimicking the basic principles of biological nervous systems.…

Neural and Evolutionary Computing · Computer Science 2022-10-06 Alvaro Ayuso-Martinez , Daniel Casanueva-Morato , Juan P. Dominguez-Morales , Angel Jimenez-Fernandez , Gabriel Jimenez-Moreno

We review enzymatic systems which involve biocatalytic reactions utilized for information processing (biocomputing). Extensive ongoing research in biocomputing, mimicking Boolean logic gates has been motivated by potential applications in…

Biological Physics · Physics 2010-10-12 Evgeny Katz , Vladimir Privman

Neural networks have been successfully applied in various resource-constrained edge devices, where usually central processing units (CPUs) instead of graphics processing units exist due to limited power availability. State-of-the-art…

Machine Learning · Computer Science 2026-01-30 Daniel Stein , Shaoyi Huang , Rolf Drechsler , Bing Li , Grace Li Zhang

Recently, research has increasingly focused on developing efficient neural network architectures. In this work, we explore logic gate networks for machine learning tasks by learning combinations of logic gates. These networks comprise logic…

Machine Learning · Computer Science 2022-10-18 Felix Petersen , Christian Borgelt , Hilde Kuehne , Oliver Deussen

While spiking neural networks (SNNs) provide a biologically inspired and energy-efficient computational framework, their robustness and the dynamic advantages inherent to biological neurons remain significantly underutilized owing to…

Neural and Evolutionary Computing · Computer Science 2025-09-04 Qianyi Bai , Haiteng Wang , Qiang Yu

A main open question in contemporary AI research is quantifying the forms of reasoning neural networks can perform when perfectly trained. This paper answers this by interpreting reasoning tasks as circuit emulation, where the gates define…

Machine Learning · Computer Science 2025-09-17 Anastasis Kratsios , Dennis Zvigelsky , Bradd Hart

Recent work in the machine learning literature has demonstrated that deep learning can train neural networks made of discrete logic gate functions to perform simple image classification tasks at very high speeds on CPU, GPU and FPGA…

Computer Vision and Pattern Recognition · Computer Science 2026-04-22 Sebastian Fieldhouse , Kea-Tiong Tang

Quantum error correcting codes protect quantum computation from errors caused by decoherence and other noise. Here we study the problem of designing logical operations for quantum error correcting codes. We present an automated procedure…

Quantum Physics · Physics 2022-10-25 Hongxiang Chen , Michael Vasmer , Nikolas P. Breuckmann , Edward Grant

Synaptic plasticity allows cortical circuits to learn new tasks and to adapt to changing environments. How do cortical circuits use plasticity to acquire functions such as decision-making or working memory? Neurons are connected in complex…

Neurons and Cognition · Quantitative Biology 2023-03-08 Néstor Parga , Luis Serrano-Fernández , Joan Falcó-Roget

While neural networks are good at learning unspecified functions from training samples, they cannot be directly implemented in hardware and are often not interpretable or formally verifiable. On the other hand, logic circuits are…

Machine Learning · Computer Science 2020-06-09 Tobias Brudermueller , Dennis L. Shung , Adrian J. Stanley , Johannes Stegmaier , Smita Krishnaswamy

Biochemical computing attempts to process information with biomolecules and biological objects. In this work we review our results on analysis and optimization of single biochemical logic gates based on enzymatic reactions, and a network of…

Molecular Networks · Quantitative Biology 2010-09-22 Mary A. Arugula , Jan Halamek , Evgeny Katz , Dmitriy Melnikov , Marcos Pita , Vladimir Privman , Guinevere Strack

Recent developments in the interfacing of neurons with silicon chips may pave the way for progress in constructing scalable neurocomputers. The assembly of synthetic neuronal networks with predefined synaptic connections and controlled…

Neurons and Cognition · Quantitative Biology 2009-01-16 Nikesh S. Dattani

We propose a novel, fully explainable neural approach to synthesis of combinatorial logic circuits from input-output examples. The carrying advantage of our method is that it readily extends to inductive scenarios, where the set of examples…

Machine Learning · Computer Science 2022-11-01 Peter Belcak , Roger Wattenhofer

Novel computing hardwares are necessary to keep up with today's increasing demand for data storage and processing power. In this research project, we turn to the brain for inspiration to develop novel computing substrates that are…

Neurons and Cognition · Quantitative Biology 2019-07-05 Kristine Heiney , Vibeke Devold Valderhaug , Ioanna Sandvig , Axel Sandvig , Gunnar Tufte , Hugo Lewi Hammer , Stefano Nichele

We advocate here the use of computational logic for systems biology, as a \emph{unified and safe} framework well suited for both modeling the dynamic behaviour of biological systems, expressing properties of them, and verifying these…

Quantitative Methods · Quantitative Biology 2020-10-07 Elisabetta de Maria , Joelle Despeyroux , Amy Felty , Pietro Liò , Carlos Olarte , Abdorrahim Bahrami
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