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Investigations of topological uniqueness of gene interaction networks in cancer cells are essential for understanding this disease. Based on the random matrix theory, we study the distribution of the nearest neighbor level spacings $P(s)$…

Molecular Networks · Quantitative Biology 2018-07-27 Ayumi Kikkawa

We study random graphs with arbitrary distributions of expected degree and derive expressions for the spectra of their adjacency and modularity matrices. We give a complete prescription for calculating the spectra that is exact in the limit…

Social and Information Networks · Computer Science 2013-02-04 Raj Rao Nadakuditi , M. E. J. Newman

Many real-world networks exhibit a high degeneracy at few eigenvalues. We show that a simple transformation of the network's adjacency matrix provides an understanding of the origins of occurrence of high multiplicities in the networks…

Physics and Society · Physics 2017-04-26 Loïc Marrec , Sarika Jalan

Although the spectra of random networks have been studied for a long time, the influence of network topology on the dense limit of network spectra remains poorly understood. By considering the configuration model of networks with four…

Disordered Systems and Neural Networks · Physics 2020-10-23 Fernando L. Metz , Jeferson D. Silva

In complex networks the degrees of adjacent nodes may often appear dependent -- which presents a modelling challenge. We present a working framework for studying networks with an arbitrary joint distribution for the degrees of adjacent…

Combinatorics · Mathematics 2020-08-25 Samuel , G. Balogh , Gergely Palla , Ivan Kryven

The spectral properties of the adjacency matrix, in particular its largest eigenvalue and the associated principal eigenvector, dominate many structural and dynamical properties of complex networks. Here we focus on the localization…

Physics and Society · Physics 2018-04-04 Romualdo Pastor-Satorras , Claudio Castellano

We study spectral behavior of sparsely connected random networks under the random matrix framework. Sub-networks without any connection among them form a network having perfect community structure. As connections among the sub-networks are…

Statistical Mechanics · Physics 2015-05-13 Sarika Jalan

The spectral properties of the adjacency matrix provide a trove of information about the structure and function of complex networks. In particular, the largest eigenvalue and its associated principal eigenvector are crucial in the…

Physics and Society · Physics 2016-01-14 Romualdo Pastor-Satorras , Claudio Castellano

The eigenvalues and eigenvectors of the connectivity matrix of complex networks contain information about its topology and its collective behavior. In particular, the spectral density $\rho(\lambda)$ of this matrix reveals important network…

Adaptation and Self-Organizing Systems · Physics 2009-11-10 M. A. M. de Aguiar , Y. Bar-Yam

Genomic alterations lead to cancer complexity and form a major hurdle for a comprehensive understanding of the molecular mechanisms underlying oncogenesis. In this review, we describe the recent advances in studying cancer-associated genes…

Molecular Networks · Quantitative Biology 2007-12-24 Edwin Wang , Anne Lenferink , Maureen O'Connor-McCourt

Based on the density of connections between the nodes of high degree, we introduce two bounds of the spectral radius. We use these bounds to split a network into two sets, one of these sets contains the high degree nodes, we refer to this…

Physics and Society · Physics 2015-12-09 R J Mondragon

In this paper, we compared cancerous and normal cell according to their protein-protein interaction network. Cancer is one of the complicated diseases and experimental investigations have been showed that protein interactions have an…

Molecular Networks · Quantitative Biology 2019-03-19 Hossein A. Rahmani , AliReza Khanteymoori , Mohammad Olyaee

We study the spectra and eigenvectors of the adjacency matrices of scale-free networks when bi-directional interaction is allowed, so that the adjacency matrix is real and symmetric. The spectral density shows an exponential decay around…

Statistical Mechanics · Physics 2009-11-07 K. -I. Goh , B. Kahng , D. Kim

The study of complex networks has been one of the most active fields in science in recent decades. Spectral properties of networks (or graphs that represent them) are of fundamental importance. Researchers have been investigating these…

Combinatorics · Mathematics 2018-09-25 Daniel Montealegre , Van Vu

Many of the structural characteristics of a network depend on the connectivity with and within the hubs. These dependencies can be related to the degree of a node and the number of links that a node shares with nodes of higher degree. In…

Physics and Society · Physics 2018-10-31 Raul J Mondragon

We analyse the eigenvectors of the adjacency matrix of a random inhomogeneous graph constructed from a specified degree sequence. We assume that the empirical degree sequence has bounded mean and variance. We show that near the edges of the…

Probability · Mathematics 2026-04-14 Thomas Buc-d'Alché , Antti Knowles

We propose a general approach to the description of spectra of complex networks. For the spectra of networks with uncorrelated vertices (and a local tree-like structure), exact equations are derived. These equations are generalized to the…

Statistical Mechanics · Physics 2009-11-10 S. N. Dorogovtsev , A. V. Goltsev , J. F. F. Mendes , A. N. Samukhin

Degree correlation is an important topological property common to many real-world networks. In this paper, the statistical measures for characterizing the degree correlation in networks are investigated analytically. We give an exact proof…

Physics and Society · Physics 2015-09-03 Ju Xiang , Ke Hu , Tao Hu , Yan Zhang , Jian-Ming Li

We analyze protein-protein interaction networks for six different species under the framework of random matrix theory. Nearest neighbor spacing distribution of the eigenvalues of adjacency matrices of the largest connected part of these…

Molecular Networks · Quantitative Biology 2014-05-20 Ankit Agrawal , Camellia Sarkar , Sanjiv K. Dwivedi , Nitesh Dhasmana , Sarika Jalan

Graph neural networks (GNNs) have shown promise in integrating protein-protein interaction (PPI) networks for identifying cancer genes in recent studies. However, due to the insufficient modeling of the biological information in PPI…

Computational Engineering, Finance, and Science · Computer Science 2025-06-24 Yilong Zang , Lingfei Ren , Yue Li , Zhikang Wang , David Antony Selby , Zheng Wang , Sebastian Josef Vollmer , Hongzhi Yin , Jiangning Song , Junhang Wu
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