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We present a brief history of the field of interpretable machine learning (IML), give an overview of state-of-the-art interpretation methods, and discuss challenges. Research in IML has boomed in recent years. As young as the field is, it…

Machine Learning · Statistics 2022-01-24 Christoph Molnar , Giuseppe Casalicchio , Bernd Bischl

Deep neural networks have been well-known for their superb handling of various machine learning and artificial intelligence tasks. However, due to their over-parameterized black-box nature, it is often difficult to understand the prediction…

Machine Learning · Computer Science 2022-07-18 Xuhong Li , Haoyi Xiong , Xingjian Li , Xuanyu Wu , Xiao Zhang , Ji Liu , Jiang Bian , Dejing Dou

Interpretable machine learning (IML) becomes increasingly important in highly regulated industry sectors related to the health and safety or fundamental rights of human beings. In general, the inherently IML models should be adopted because…

Machine Learning · Computer Science 2021-11-03 Agus Sudjianto , Aijun Zhang

Large language models (LLMs) have emerged as a powerful foundation for intelligent reasoning and decision-making, demonstrating substantial impact across a wide range of domains and applications. However, their massive parameter scales and…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-12-29 Mingyu Sun , Xiao Zhang , Shen Qu , Yan Li , Mengbai Xiao , Yuan Yuan , Dongxiao Yu

In the present paper we present the potential of Explainable Artificial Intelligence methods for decision-support in medical image analysis scenarios. With three types of explainable methods applied to the same medical image data set our…

Artificial Intelligence · Computer Science 2021-05-20 Samanta Knapič , Avleen Malhi , Rohit Saluja , Kary Främling

Sparse autoencoders (SAEs) have become a standard tool for mechanistic interpretability in autoregressive large language models (LLMs), enabling researchers to extract sparse, human-interpretable features and intervene on model behavior.…

Machine Learning · Computer Science 2026-02-06 Xu Wang , Bingqing Jiang , Yu Wan , Baosong Yang , Lingpeng Kong , Difan Zou

Large language models have exhibited impressive performance across a broad range of downstream tasks in natural language processing. However, how a language model predicts the next token and generates content is not generally understandable…

We introduce a family of interpretable machine learning models, with two broad additions: Linearised Additive Models (LAMs) which replace the ubiquitous logistic link function in General Additive Models (GAMs); and SubscaleHedge, an expert…

Machine Learning · Computer Science 2022-11-14 Danial Dervovic , Nicolas Marchesotti , Freddy Lecue , Daniele Magazzeni

Interpretability is critical in high-stakes domains such as medical imaging, where understanding model decisions is essential for clinical adoption. In this work, we introduce Sparse Autoencoder (SAE)-based interpretability to breast…

Computer Vision and Pattern Recognition · Computer Science 2025-08-19 Krishna Kanth Nakka

Artificial Text Detection (ATD) is becoming increasingly important with the rise of advanced Large Language Models (LLMs). Despite numerous efforts, no single algorithm performs consistently well across different types of unseen text or…

As machine learning black boxes are increasingly being deployed in critical domains such as healthcare and criminal justice, there has been a growing emphasis on developing techniques for explaining these black boxes in a post hoc manner.…

Machine Learning · Computer Science 2021-07-20 Sushant Agarwal , Shahin Jabbari , Chirag Agarwal , Sohini Upadhyay , Zhiwei Steven Wu , Himabindu Lakkaraju

The financial industry faces a significant challenge modeling and risk portfolios: balancing the predictability of advanced machine learning models, neural network models, and explainability required by regulatory entities (such as Office…

Machine Learning · Computer Science 2025-11-10 Rongbin Ye , Jiaqi Chen

Black-box deep neural networks excel in text classification, yet their application in high-stakes domains is hindered by their lack of interpretability. To address this, we propose Text Bottleneck Models (TBM), an intrinsically…

Computation and Language · Computer Science 2024-04-04 Josh Magnus Ludan , Qing Lyu , Yue Yang , Liam Dugan , Mark Yatskar , Chris Callison-Burch

Large language models (LLMs) excel at handling human queries, but they can occasionally generate flawed or unexpected responses. Understanding their internal states is crucial for understanding their successes, diagnosing their failures,…

Computation and Language · Computer Science 2025-02-24 Xuansheng Wu , Jiayi Yuan , Wenlin Yao , Xiaoming Zhai , Ninghao Liu

Interpretability remains a key challenge for deploying large language models (LLMs) in clinical settings such as Alzheimer's disease progression diagnosis, where early and trustworthy predictions are essential. Existing attribution methods…

Recent developments in single-cell omics technologies have enabled the quantification of molecular profiles in individual cells at an unparalleled resolution. Deep learning, a rapidly evolving sub-field of machine learning, has instilled a…

Genomics · Quantitative Biology 2024-01-17 Manoj M Wagle , Siqu Long , Carissa Chen , Chunlei Liu , Pengyi Yang

Large language models (LLMs) can generate long-form and coherent text, yet they often hallucinate facts, which undermines their reliability. To mitigate this issue, inference-time methods steer LLM representations toward the "truthful…

Computation and Language · Computer Science 2024-06-10 Farima Fatahi Bayat , Xin Liu , H. V. Jagadish , Lu Wang

Recently generating natural language explanations has shown very promising results in not only offering interpretable explanations but also providing additional information and supervision for prediction. However, existing approaches…

Computation and Language · Computer Science 2022-05-30 Wangchunshu Zhou , Jinyi Hu , Hanlin Zhang , Xiaodan Liang , Maosong Sun , Chenyan Xiong , Jian Tang

Visual foundation models (VFMs) have become increasingly popular due to their state-of-the-art performance. However, interpretability remains crucial for critical applications. In this sense, self-explainable models (SEM) aim to provide…

Computer Vision and Pattern Recognition · Computer Science 2025-02-28 Hugues Turbé , Mina Bjelogrlic , Gianmarco Mengaldo , Christian Lovis

Deep learning models for learning analytics have become increasingly popular over the last few years; however, these approaches are still not widely adopted in real-world settings, likely due to a lack of trust and transparency. In this…

Computers and Society · Computer Science 2023-03-08 Vinitra Swamy , Sijia Du , Mirko Marras , Tanja Käser