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Related papers: Towards a general model for psychopathology

200 papers

Both neurobiological and environmental factors are known to play a role in the origin of schizophrenia, but no model has been proposed that accounts for both. This work presents a functional model of schizophrenia that merges psychodynamic…

Neurons and Cognition · Quantitative Biology 2017-03-10 Alessandro Fontana

Mental health disorders, particularly cognitive disorders defined by deficits in cognitive abilities, are described in detail in the DSM-5, which includes definitions and examples of signs and symptoms. A simplified, machine-actionable…

Machine Learning · Computer Science 2025-11-26 Raoul H. Kutil , Georg Zimmermann , Barbara Strasser-Kirchweger , Christian Borgelt

Differential diagnosis of mental disorders remains a fundamental challenge in real-world clinical practice, where multiple conditions often exhibit overlapping symptoms. However, most existing public datasets are developed under…

Psychological traumas are thought to be present in a wide range of conditions, including post-traumatic stress disorder, disorganised attachment, personality disorders, dissociative identity disorder and psychosis. This work presents a new…

Neurons and Cognition · Quantitative Biology 2018-03-08 Alessandro Fontana

Mental disease detection (MDD) from social media has suffered from poor generalizability and interpretability, due to lack of symptom modeling. This paper introduces PsySym, the first annotated symptom identification corpus of multiple…

Computation and Language · Computer Science 2022-05-24 Zhiling Zhang , Siyuan Chen , Mengyue Wu , Kenny Q. Zhu

Major depressive disorder persistently stands as a major public health problem. While some progress has been made toward effective treatments, the neural mechanisms that give rise to the disorder remain poorly understood. In this…

Neurons and Cognition · Quantitative Biology 2025-07-23 Matthew Botvinick , Zeb Kurth-Nelson , Timothy Muller , Will Dabney

Depression is a pervasive mental health condition that affects hundreds of millions of individuals worldwide, yet many cases remain undiagnosed due to barriers in traditional clinical access and pervasive stigma. Social media platforms, and…

Computation and Language · Computer Science 2025-08-06 Eliseo Bao , Anxo Pérez , Javier Parapar

Depression is a widespread mental disorder that affects millions worldwide. While automated depression assessment shows promise, most studies rely on limited or non-clinically validated data, and often prioritize complex model design over…

Computation and Language · Computer Science 2025-08-07 Zhuang Chen , Guanqun Bi , Wen Zhang , Jiawei Hu , Aoyun Wang , Xiyao Xiao , Kun Feng , Minlie Huang

Current psychiatric research is in crisis. In this review I will describe the causes of this crisis and highlight recent efforts to overcome current challenges. One particularly promising approach is the emerging field of computational…

Neurons and Cognition · Quantitative Biology 2013-03-25 Thomas V. Wiecki

Large language model-powered chatbots have transformed how people seek information, especially in high-stakes contexts like mental health. Despite their support capabilities, safe detection and response to crises such as suicidal ideation…

Computation and Language · Computer Science 2026-04-09 Adrian Arnaiz-Rodriguez , Miguel Baidal , Erik Derner , Jenn Layton Annable , Mark Ball , Mark Ince , Elvira Perez Vallejos , Nuria Oliver

This study integrates causal inference, graph analysis, temporal complexity measures, and machine learning to examine whether individual symptom trajectories can reveal meaningful diagnostic patterns. Testing on a longitudinal dataset of…

Applications · Statistics 2025-07-22 Eleonora Vitanza , Pietro DeLellis , Chiara Mocenni , Manuel Ruiz Marin

Psychological defense mechanisms (PDMs) are unconscious cognitive processes that modulate how individuals perceive and respond to emotional distress. Automatically classifying PDMs from text is clinically valuable but severely hindered by…

Computation and Language · Computer Science 2026-05-15 Hoang-Thuy-Duong Vu , Quoc-Cuong Pham , Huy-Hieu Pham

Anxiety and depression are the most common mental health issues worldwide, affecting a non-negligible part of the population. Accordingly, stakeholders, including governments' health systems, are developing new strategies to promote early…

Artificial Intelligence · Computer Science 2024-12-24 Francisco de Arriba-Pérez , Silvia García-Méndez

The differential diagnosis of neurodegenerative diseases, characterized by overlapping symptoms, may be challenging. Brain imaging coupled with artificial intelligence has been previously proposed for diagnostic support, but most of these…

Image and Video Processing · Electrical Eng. & Systems 2025-02-21 Pierrick Coupé , Boris Mansencal , José V. Manjón , Patrice Péran , Wassilios G. Meissner , Thomas Tourdias , Vincent Planche

Depression has affected millions of people worldwide and has become one of the most common mental disorders. Early mental disorder detection can reduce costs for public health agencies and prevent other major comorbidities. Additionally,…

Computation and Language · Computer Science 2024-04-09 Giuliano Lorenzoni , Cristina Tavares , Nathalia Nascimento , Paulo Alencar , Donald Cowan

The advancement of AI systems for mental health support is hindered by limited access to therapeutic conversation data, particularly for trauma treatment. We present Thousand Voices of Trauma, a synthetic benchmark dataset of 3,000 therapy…

Computers and Society · Computer Science 2025-05-19 Suhas BN , Andrew M. Sherrill , Rosa I. Arriaga , Chris W. Wiese , Saeed Abdullah

Due to the complexity of the human body, most diseases present a high inter-personal variability in the way they manifest, i.e. in their phenotype, which has important clinical repercussions - as for instance the difficulty in defining…

Physics and Society · Physics 2018-06-06 Massimiliano Zanin , Juan Manuel Tuñas , Ernestina Menasalvas

The deployment of large language models (LLMs) as interactive agents has exposed a category of behavioral failure that prevailing terminology, principally hallucination, fails to adequately characterize. This paper introduces LLM Psychosis…

Computers and Society · Computer Science 2026-04-30 Ashutosh Raj

In this paper, we propose a theoretical framework for evaluating psychiatric research strategies. The strategies to be evaluated include a conventional diagnostic category-based approach and dimensional approach that have been encouraged by…

Applications · Statistics 2016-09-02 Kentaro Katahira , Yuichi Yamashita

Single subject prediction of brain disorders from neuroimaging data has gained increasing attention in recent years. Yet, for some heterogeneous disorders such as major depression disorder (MDD) and autism spectrum disorder (ASD), the…

Machine Learning · Computer Science 2022-06-08 Ahmed El Gazzar , Rajat Mani Thomas , Guido Van Wingen
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