Related papers: Universality of clone dynamics during tissue devel…
Molecular traits, such as gene expression levels or protein binding affinities, are increasingly accessible to quantitative measurement by modern high-throughput techniques. Such traits measure molecular functions and, from an evolutionary…
Cellular renewing active matter - assemblies of proliferating and apoptotic cells - underlies tissue homeostasis, morphogenesis, and clonal competition. Previous work in one-dimensional periodic systems identified a fitness advantage…
What features characterise complex system dynamics? Power laws and scale invariance of fluctuations are often taken as the hallmarks of complexity, drawing on analogies with equilibrium critical phenomena[1-3]. Here we argue that slow,…
Cellular systems are observed everywhere in nature, from crystal domains in metals, soap froth and cucumber cells to the network of cosmological voids. Surprisingly, despite their disparate scale and origin all cellular systems follow…
Research done during the previous century established our Standard Cosmological Model. There are many details still to be filled in, but few would seriously doubt the basic premise. Past surveys have revealed that the large-scale…
The emergence of spatial patterns and organized growth is a hallmark of developing tissues. While symmetry-breaking and scaling laws govern these processes, how cells coordinate spatial patterning with size regulation remains unclear. Here,…
The formation of galaxy clusters in hierarchically clustering universes is investigated by means of high resolution N-body simulations. The simulations are performed using a newly developed multi-mass scheme which combines a PM code with a…
Evidence of critical dynamics has been recently found in both experiments and models of large scale brain dynamics. The understanding of the nature and features of such critical regime is hampered by the relatively small size of the…
Multicellular organisms contain a wide variety of highly specialized cell types. The consistency and robustness of developmental trajectories suggest that complex gene regulatory networks effectively act as low-dimensional cell fate…
Locomotion is essential for living cells. It enables bacteria and algae to explore space for food, cancer to spread, and immune system to fight infections. Motile cells display trajectories of intriguing complexity, from regular (e.g.…
Individual-based models of chemical or biological dynamics usually consider individual entities diffusing in space and performing a birth-death type dynamics. In this work we study the properties of a model in this class where the birth…
We study correlation properties of the generalized elastic model which accounts for the dynamics of polymers, membranes, surfaces and fluctuating interfaces, among others. We develop a theoretical framework which leads to the emergence of…
Pattern formation often occurs in confined systems, yet how boundaries shape patterning dynamics is unclear. We develop techniques to analyze confinement effects in nonlocal advection-diffusion equations, which generically capture the…
The dynamics based on information transfer is proposed as an underlying mechanism for the scale-invariant dynamic critical behavior observed in a variety of systems. We apply the dynamics to the globally-coupled Ising model, which is…
Isolated many-body systems far from equilibrium may exhibit scaling dynamics with universal exponents indicating the proximity of the time-evolution to a non-thermal fixed point. We find universal dynamics connected with the occurrence of…
Crystal plasticity is the result of the motion and interaction of dislocations. There is, however, still a major gap between microscopic and mesoscopic simulations and continuum crystal plasticity models. Only recently a higher dimensional…
Evolution has fascinated quantitative and physical scientists for decades: how can the random process of mutation, recombination, and duplication of genetic information generate the diversity of life? What determines the rate of evolution?…
Through extensive studies of dynamical system modeling cellular growth and reproduction, we find evidence that complexity arises in multicellular organisms naturally through evolution. Without any elaborate control mechanism, these systems…
The universality class of the avalanche behavior in plastically deforming crystalline and amorphous systems has been commonly discussed, despite the fact that the microscopic defect character in each of these systems is different. In…
Understanding cellular response to mechanical forces is immensely important for a plethora of biological processes. Focal adhesions are multi-molecular protein assemblies that connect the cell to the extracellular matrix and play a pivotal…