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Accurate predictions of peptide retention times (RT) in liquid chromatography have many applications in mass spectrometry-based proteomics. Herein, we present DeepRT, a deep learning based software for peptide retention time prediction.…

Quantitative Methods · Quantitative Biology 2017-05-17 Chunwei Ma , Zhiyong Zhu , Jun Ye , Jiarui Yang , Jianguo Pei , Shaohang Xu , Ruo Zhou , Chang Yu , Fan Mo , Bo Wen , Siqi Liu

Semantics based knowledge representations such as ontologies are found to be very useful in automatically generating meaningful factual questions. Determining the difficulty level of these system generated questions is helpful to…

Artificial Intelligence · Computer Science 2017-09-05 Vinu E. , P Sreenivasa Kumar

Neural population activity is theorized to reflect an underlying dynamical structure. This structure can be accurately captured using state space models with explicit dynamics, such as those based on recurrent neural networks (RNNs).…

Neurons and Cognition · Quantitative Biology 2023-07-21 Joel Ye , Chethan Pandarinath

Item Response Theory (IRT) was originally developed in traditional exam settings, and it has been shown that the model does not readily transfer to formative assessment in the form of online homework. We investigate if this is mostly due to…

Physics Education · Physics 2015-03-24 Emre Gönülateş , Gerd Kortemeyer

Item difficulty plays a crucial role in test performance, interpretability of scores, and equity for all test-takers, especially in large-scale assessments. Traditional approaches to item difficulty modeling rely on field testing and…

Computation and Language · Computer Science 2025-09-30 Sydney Peters , Nan Zhang , Hong Jiao , Ming Li , Tianyi Zhou , Robert Lissitz

In natural language processing (NLP), deep neural networks (DNNs) could model complex interactions between context and have achieved impressive results on a range of NLP tasks. Prior works on feature interaction attribution mainly focus on…

Computation and Language · Computer Science 2023-10-27 Xiaolei Lu , Jianghong Ma , Haode Zhang

State-of-the-art natural language processing (NLP) models often learn to model dataset biases and surface form correlations instead of features that target the intended underlying task. Previous work has demonstrated effective methods to…

Computation and Language · Computer Science 2020-12-03 Victor Sanh , Thomas Wolf , Yonatan Belinkov , Alexander M. Rush

This study discusses an alternative tool for modeling student assessment data. The model constructs networks from a matrix item responses and attempts to represent these data in low dimensional Euclidean space. This procedure has advantages…

Applications · Statistics 2020-03-18 Alex Brodersen , Ick Hoon Jin , Ying Cheng , Minjeong Jeon

Interpreting the performance of deep learning models beyond test set accuracy is challenging. Characteristics of individual data points are often not considered during evaluation, and each data point is treated equally. We examine the…

Computation and Language · Computer Science 2018-09-11 John P. Lalor , Hao Wu , Tsendsuren Munkhdalai , Hong Yu

Random Matrix Theory (RMT) is applied to analyze weight matrices of Deep Neural Networks (DNNs), including both production quality, pre-trained models such as AlexNet and Inception, and smaller models trained from scratch, such as LeNet5…

Machine Learning · Computer Science 2018-10-03 Charles H. Martin , Michael W. Mahoney

Item Response Theory (IRT) models are widely used to estimate respondents' latent abilities and calibrate item difficulty. Traditional IRT estimation typically requires centralizing all raw responses, raising privacy and governance…

Machine Learning · Computer Science 2026-04-07 Biying Zhou , Nanyu Luo , Feng Ji

Reading comprehension is a key for individual success, yet the assessment of question difficulty remains challenging due to the extensive human annotation and large-scale testing required by traditional methods such as linguistic analysis…

Computation and Language · Computer Science 2025-02-26 Yoshee Jain , John Hollander , Amber He , Sunny Tang , Liang Zhang , John Sabatini

Sequences and time-series often arise in robot tasks, e.g., in activity recognition and imitation learning. In recent years, deep neural networks (DNNs) have emerged as an effective data-driven methodology for processing sequences given…

Artificial Intelligence · Computer Science 2021-01-29 Yaqi Xie , Fan Zhou , Harold Soh

Collaborative filtering is used to recommend items to a user without requiring a knowledge of the item itself and tends to outperform other techniques. However, collaborative filtering suffers from the cold-start problem, which occurs when…

Machine Learning · Computer Science 2014-06-10 Michael R. Smith , Tony Martinez , Michael Gashler

Evaluating large language models (LLMs) typically requires thousands of benchmark items, making the process expensive, slow, and increasingly impractical at scale. Existing evaluation protocols rely on average accuracy over fixed item sets,…

Computation and Language · Computer Science 2026-02-03 Peiyu Li , Xiuxiu Tang , Si Chen , Ying Cheng , Ronald Metoyer , Ting Hua , Nitesh V. Chawla

Preference-based reinforcement learning (RL) provides a framework to train AI agents using human feedback through preferences over pairs of behaviors, enabling agents to learn desired behaviors when it is difficult to specify a numerical…

Human-Computer Interaction · Computer Science 2025-03-21 David Chhan , Ellen Novoseller , Vernon J. Lawhern

Fine-tuned pre-trained language models (PLMs) have achieved awesome performance on almost all NLP tasks. By using additional prompts to fine-tune PLMs, we can further stimulate the rich knowledge distributed in PLMs to better serve…

Computation and Language · Computer Science 2021-09-16 Xu Han , Weilin Zhao , Ning Ding , Zhiyuan Liu , Maosong Sun

Prompt-based learning, with its capability to tackle zero-shot and few-shot NLP tasks, has gained much attention in community. The main idea is to bridge the gap between NLP downstream tasks and language modeling (LM), by mapping these…

Computation and Language · Computer Science 2022-11-21 Yulong Chen , Yang Liu , Li Dong , Shuohang Wang , Chenguang Zhu , Michael Zeng , Yue Zhang

In this paper, we demonstrate how Large Language Models (LLMs) can effectively learn to use an off-the-shelf information retrieval (IR) system specifically when additional context is required to answer a given question. Given the…

Computation and Language · Computer Science 2024-05-08 Tiziano Labruna , Jon Ander Campos , Gorka Azkune

Understanding how animals learn is a central challenge in neuroscience, with growing relevance to the development of animal- or human-aligned artificial intelligence. However, existing approaches tend to assume fixed parametric forms for…

Machine Learning · Computer Science 2026-02-06 Yuhan Helena Liu , Victor Geadah , Jonathan Pillow