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Intensive longitudinal data, characterized by frequent measurements across numerous time points, are increasingly common due to advances in wearable devices and mobile health technologies. We consider evaluating causal mediation pathways…

Methodology · Statistics 2025-06-26 Tianchen Qian

Mediation analysis examines the pathways through which mediators transmit the effect of an exposure to an outcome. In high-dimensional settings, the joint significance test is commonly applied using variable screening followed by…

Methodology · Statistics 2025-08-26 Samuel Osarfo , Sangyoon Yi , Weijia Fu , Seungjun Ahn

In epidemiological research, causal models incorporating potential mediators along a pathway are crucial for understanding how exposures influence health outcomes. This work is motivated by integrated epidemiological and blood biomarker…

Methodology · Statistics 2024-11-28 Youngho Bae , Chanmin Kim , Fenglei Wang , Qi Sun , Kyu Ha Lee

With advanced imaging, sequencing, and profiling technologies, multiple omics data become increasingly available and hold promises for many healthcare applications such as cancer diagnosis and treatment. Multimodal learning for integrative…

Genomics · Quantitative Biology 2022-12-20 Sina Tabakhi , Mohammod Naimul Islam Suvon , Pegah Ahadian , Haiping Lu

The recent explosion of interest in multimodal applications has resulted in a wide selection of datasets and methods for representing and integrating information from different modalities. Despite these empirical advances, there remain…

Recent advancements in the acquisition of various brain data sources have created new opportunities for integrating multimodal brain data to assist in early detection of complex brain disorders. However, current data integration approaches…

Image and Video Processing · Electrical Eng. & Systems 2023-05-26 Reza Shirkavand , Liang Zhan , Heng Huang , Li Shen , Paul M. Thompson

Multimodal medical imaging plays a pivotal role in clinical diagnosis and research, as it combines information from various imaging modalities to provide a more comprehensive understanding of the underlying pathology. Recently, deep…

Computer Vision and Pattern Recognition · Computer Science 2024-04-24 Yihao Li , Mostafa El Habib Daho , Pierre-Henri Conze , Rachid Zeghlache , Hugo Le Boité , Ramin Tadayoni , Béatrice Cochener , Mathieu Lamard , Gwenolé Quellec

This article deals with the analysis of high dimensional data that come from multiple sources (experiments) and thus have different possibly correlated responses, but share the same set of predictors. The measurements of the predictors may…

Methodology · Statistics 2020-07-01 Guorong Dai , Ursula U. Müller , Raymond J. Carroll

Conversations contain a wide spectrum of multimodal information that gives us hints about the emotions and moods of the speaker. In this paper, we developed a system that supports humans to analyze conversations. Our main contribution is…

Human-Computer Interaction · Computer Science 2020-01-29 Joshua Y. Kim , Greyson Y. Kim , Kalina Yacef

Cancer has relational information residing at varying scales, modalities, and resolutions of the acquired data, such as radiology, pathology, genomics, proteomics, and clinical records. Integrating diverse data types can improve the…

Machine Learning · Computer Science 2024-07-29 Asim Waqas , Aakash Tripathi , Ravi P. Ramachandran , Paul Stewart , Ghulam Rasool

Understanding neural activity and information representation is crucial for advancing knowledge of brain function and cognition. Neural activity, measured through techniques like electrophysiology and neuroimaging, reflects various aspects…

Neurons and Cognition · Quantitative Biology 2024-07-22 Fengyu Yang , Chao Feng , Daniel Wang , Tianye Wang , Ziyao Zeng , Zhiyang Xu , Hyoungseob Park , Pengliang Ji , Hanbin Zhao , Yuanning Li , Alex Wong

The exploration of brain-heart interactions within various paradigms, including affective computing, human-computer interfaces, and sensorimotor evaluation, stands as a significant milestone in biomarker development and neuroscientific…

Other Quantitative Biology · Quantitative Biology 2026-04-27 Diego Candia-Rivera , Luca Faes , Fabrizio De Vico Fallani , Mario Chavez

Traditional psychological evaluations rely heavily on human observation and interpretation, which are prone to subjectivity, bias, fatigue, and inconsistency. To address these limitations, this work presents a multimodal emotion recognition…

Human-Computer Interaction · Computer Science 2024-12-25 Kris Kraack

Multimodal machine learning (MML) is rapidly reshaping the way mental-health disorders are detected, characterized, and longitudinally monitored. Whereas early studies relied on isolated data streams -- such as speech, text, or wearable…

Machine Learning · Computer Science 2025-06-25 Zahraa Al Sahili , Ioannis Patras , Matthew Purver

High-dimensional mediation analysis aims to identify mediating pathways and to estimate indirect effects linking an exposure to an outcome. In this paper, we propose a Bayesian framework to address key challenges in these analyses,…

Methodology · Statistics 2026-02-13 Youngho Bae , Chanmin Kim , Fenglei Wang , Qi Sun , Kyu Ha Lee

Characterizing the dynamic interactive patterns of complex systems helps gain in-depth understanding of how components interrelate with each other while performing certain functions as a whole. In this study, we present a novel multimodal…

Machine Learning · Computer Science 2019-01-07 Miaolin Fan , Chun-An Chou , Sheng-Che Yen , Yingzi Lin

Sophisticated visualization tools are essential for the presentation and exploration of human neuroimaging data. While two-dimensional orthogonal views of neuroimaging data are conventionally used to display activity and statistical…

The need for multimodal data integration arises naturally when multiple complementary sets of features are measured on the same sample. Under a dependent multifactor model, we develop a fully data-driven orchestrated approximate message…

Methodology · Statistics 2026-01-22 Sagnik Nandy , Zongming Ma

Despite participants engaging in unimodal stimuli, such as watching images or silent videos, recent work has demonstrated that multi-modal Transformer models can predict visual brain activity impressively well, even with incongruent…

Neurons and Cognition · Quantitative Biology 2025-05-27 Subba Reddy Oota , Khushbu Pahwa , Mounika Marreddy , Maneesh Singh , Manish Gupta , Bapi S. Raju

Recent neuroimaging studies that focus on predicting brain disorders via modern machine learning approaches commonly include a single modality and rely on supervised over-parameterized models.However, a single modality provides only a…