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Human brains lie at the core of complex neurobiological systems, where the neurons, circuits, and subsystems interact in enigmatic ways. Understanding the structural and functional mechanisms of the brain has long been an intriguing pursuit…

Neurons and Cognition · Quantitative Biology 2022-07-26 Hejie Cui , Wei Dai , Yanqiao Zhu , Xiaoxiao Li , Lifang He , Carl Yang

Functional connectivity, as estimated using resting state fMRI, has shown potential in bridging the gap between pathophysiology and cognition. However, clinical use of functional connectivity biomarkers is impeded by unreliable estimates of…

Human brains are commonly modeled as networks of Regions of Interest (ROIs) and their connections for the understanding of brain functions and mental disorders. Recently, Transformer-based models have been studied over different types of…

Machine Learning · Computer Science 2022-10-18 Xuan Kan , Wei Dai , Hejie Cui , Zilong Zhang , Ying Guo , Carl Yang

Dataset is the key of deep learning in Autism disease research. However, due to the few quantity and heterogeneity of samples in current dataset, for example ABIDE (Autism Brain Imaging Data Exchange), the recognition research is not…

Machine Learning · Computer Science 2022-02-22 Haonan Sun , Qiang He , Shouliang Qi , Yudong Yao , Yueyang Teng

Determining biomarkers for autism spectrum disorder (ASD) is crucial to understanding its mechanisms. Recently deep learning methods have achieved success in the classification task of ASD using fMRI data. However, due to the black-box…

Computer Vision and Pattern Recognition · Computer Science 2019-10-14 Juntang Zhuang , Nicha C. Dvornek , Xiaoxiao Li , Pamela Ventola , James S. Duncan

The underlying anatomical structure is fundamental to the study of brain networks, but the role of brainstem from a structural perspective is not very well understood. We conduct a computational and graph-theoretical study of the human…

Neurons and Cognition · Quantitative Biology 2023-04-26 Salma Salhi , Youssef Kora , Gisu Ham , Hadi Zadeh Haghighi , Christoph Simon

The goal of the present study is to identify autism using machine learning techniques and resting-state brain imaging data, leveraging the temporal variability of the functional connections (FC) as the only information. We estimated and…

Neurons and Cognition · Quantitative Biology 2017-12-22 Ravi Tejwani , Adam Liska , Hongyuan You , Jenna Reinen , Payel Das

Autism Spectrum Disorder (ASD) lacks reliable biological markers, delaying early diagnosis. Using 159 salivary samples analyzed by ATR-FTIR spectroscopy, we developed GANet, a genetic algorithm-based network optimization framework…

Machine Learning · Computer Science 2025-09-22 Janayna M. Fernandes , Robinson Sabino-Silva , Murillo G. Carneiro

Brain-computer interfaces (BCIs) make possible to interact with the external environment by decoding the mental intention of individuals. BCIs can therefore be used to address basic neuroscience questions but also to unlock a variety of…

Neurons and Cognition · Quantitative Biology 2021-02-12 Juliana Gonzalez-Astudillo , Tiziana Cattai , Giulia Bassignana , Marie-Constance Corsi , Fabrizio De Vico Fallani

We propose a unified optimization framework that combines neural networks with dictionary learning to model complex interactions between resting state functional MRI and behavioral data. The dictionary learning objective decomposes patient…

Machine Learning · Computer Science 2024-11-21 Niharika Shimona D'Souza , Mary Beth Nebel , Nicholas Wymbs , Stewart Mostofsky , Archana Venkataraman

Autism Spectrum Disorder (ASD) is a chronic neurodevelopmental condition characterized by repetitive behaviors and impairments in social and communication skills. Despite the clear manifestation of these symptoms, many individuals with ASD…

Machine Learning · Computer Science 2026-01-27 Aneesh Panchal , Kainat Khan , Rahul Katarya

Estimating a representative and discriminative brain network atlas (BNA) is a nascent research field in mapping a population of brain networks in health and disease. Although limited, existing BNA estimation methods have several…

Machine Learning · Computer Science 2020-09-24 Islem Mhiri , Mohamed Ali Mahjoub , Islem Rekik

The connectome, a map of the structural and/or functional connections in the brain, provides a complex representation of the neurobiological phenotypes on which it supervenes. This information-rich data modality has the potential to…

The continuous integration of experimental data into coherent models of the brain is an increasing challenge of modern neuroscience. Such models provide a bridge between structure and activity, and identify the mechanisms giving rise to…

Neurons and Cognition · Quantitative Biology 2017-03-03 Jannis Schuecker , Maximilian Schmidt , Sacha J. van Albada , Markus Diesmann , Moritz Helias

Brain networks characterize complex connectivities among brain regions as graph structures, which provide a powerful means to study brain connectomes. In recent years, graph neural networks have emerged as a prevalent paradigm of learning…

Machine Learning · Computer Science 2022-06-10 Yi Yang , Yanqiao Zhu , Hejie Cui , Xuan Kan , Lifang He , Ying Guo , Carl Yang

Topological data analysis (TDA) approaches are becoming increasingly popular for studying the dependence patterns in multivariate time series data. In particular, various dependence patterns in brain networks may be linked to specific tasks…

Methodology · Statistics 2025-12-08 Anass El Yaagoubi Bourakna , Moo K. Chung , Hernando Ombao

Designing network parameters that can effectively represent complex networks is of significant importance for the analysis of time-varying complex networks. This paper introduces a novel thermodynamic framework for analyzing complex…

Quantitative Methods · Quantitative Biology 2024-09-04 Dayu Qin , Yuzhe Chen , Ercan Engin Kuruoglu

In this work we focus on examination and comparison of whole-brain functional connectivity patterns measured with fMRI across experimental conditions. Direct examination and comparison of condition-specific matrices is challenging due to…

Applications · Statistics 2013-01-02 Svetlana V. Shinkareva , Vladimir Gudkov , Jing Wang

This paper presents a comprehensive and quality collection of functional human brain network data for potential research in the intersection of neuroscience, machine learning, and graph analytics. Anatomical and functional MRI images have…

In this study, we propose a neural network approach to capture the functional connectivities among anatomic brain regions. The suggested approach estimates a set of brain networks, each of which represents the connectivity patterns of a…

Computer Vision and Pattern Recognition · Computer Science 2018-07-24 Baran Baris Kivilcim , Itir Onal Ertugrul , Fatos T. Yarman Vural