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Optimization-based solvers play a central role in a wide range of signal processing and communication tasks. However, their applicability in latency-sensitive systems is limited by the sequential nature of iterative methods and the high…

Signal Processing · Electrical Eng. & Systems 2026-03-12 Dvir Avrahami , Amit Milstein , Caroline Chaux , Tirza Routtenberg , Nir Shlezinger

Calculating the molecular ground-state energy is a central challenge in computational chemistry. Conventional methods such as the Complete Active Space Configuration Interaction scale exponentially with molecular size, limiting their…

Quantum Physics · Physics 2025-12-15 Stefano Bruni , Enrico Prati

It is the first step for understanding how RNA structure folds from base sequences that to know how its secondary structure is formed. Traditional energy-based algorithms are short of precision, particularly for non-nested sequences, while…

Quantum Physics · Physics 2023-05-18 Ji Jiang , Qipeng Yan , Ye Li , Min Lu , Ziwei Cui , Menghan Dou , Qingchun Wang , Yu-Chun Wu , Guo-Ping Guo

Protein folding is a central challenge in computational biology, with important applications in molecular biology, drug discovery and catalyst design. As a hard combinatorial optimisation problem, it has been studied as a potential target…

Quantum annealing algorithms belong to the class of metaheuristic tools, applicable for solving binary optimization problems. Hardware implementations of quantum annealing, such as the quantum annealing machines produced by D-Wave Systems,…

Quantum Physics · Physics 2017-09-18 Florian Neukart , David Von Dollen , Christian Seidel , Gabriele Compostella

Quantum and Classical computers continue to work together in tight cooperation to solve difficult problems. The combination is thus suggested in recent times for decoding the Low Density Parity Check (LDPC) codes, for the next generation…

Quantum Physics · Physics 2022-09-27 Utso Majumder , Aditya Das Sarma , Vishnu Vaidya , M Girish Chandra

Quantum annealers like those from D-Wave Systems implement adiabatic quantum computing to solve optimization problems, but their analog nature and limited control functionalities present challenges to correcting or mitigating errors. As…

Quantum Physics · Physics 2024-04-11 Hristo N. Djidjev

Quantum annealing is a generic solver for combinatorial optimization problems that utilizes quantum fluctuations. Recently, there has been extensive research applying quantum annealers, which are hardware implementations of quantum…

Quantum Physics · Physics 2025-04-22 Taisei Takabayashi , Takeru Goto , Masayuki Ohzeki

We address the problem of sensing the curvature of a manifold by performing measurements on a particle constrained to the manifold itself. In particular, we consider situations where the dynamics of the particle is quantum mechanical and…

Quantum Physics · Physics 2019-10-02 Daniele Bonalda , Luigi Seveso , Matteo G. A. Paris

This work focuses on quantum methods for cryptanalysis of schemes based on the integer factorization problem and the discrete logarithm problem. We demonstrate how to practically solve the largest instances of the factorization problem by…

Cryptography and Security · Computer Science 2024-10-08 Olgierd Żołnierczyk

Optimal parameter setting for applications problems embedded into hardware graphs is key to practical quantum annealers (QA). Embedding chains typically crop up as harmful Griffiths phases, but can be used as a resource as we show here: to…

Quantum Physics · Physics 2021-01-04 Sergey Knysh , Eugeniu Plamadeala , Davide Venturelli

Quantum annealing is a heuristic quantum algorithm which exploits quantum resources to minimize an objective function embedded as the energy levels of a programmable physical system. To take advantage of a potential quantum advantage, one…

Machine Learning · Computer Science 2014-06-18 Ryan Babbush , Vasil Denchev , Nan Ding , Sergei Isakov , Hartmut Neven

Characterizing thermally activated transitions in high-dimensional rugged energy surfaces is a very challenging task for classical computers. Here, we develop a quantum annealing scheme to solve this problem. First, the task of finding the…

Quantum Physics · Physics 2021-01-18 Philipp Hauke , Giovanni Mattiotti , Pietro Faccioli

We formulate maximum likelihood (ML) channel decoding as a quadratic unconstraint binary optimization (QUBO) and simulate the decoding by the current commercial quantum annealing machine, D-Wave 2000Q. We prepared two implementations with…

Information Theory · Computer Science 2020-10-06 Naoki Ide , Tetsuya Asayama , Hiroshi Ueno , Masayuki Ohzeki

Transcription factors regulate gene expression, but how these proteins recognize and specifically bind to their DNA targets is still debated. Machine learning models are effective means to reveal interaction mechanisms. Here we studied the…

Quantum Physics · Physics 2018-03-02 Richard Y. Li , Rosa Di Felice , Remo Rohs , Daniel A. Lidar

Solving linear systems of equations is an important problem in science and engineering. Many quantum algorithms, such as the Harrow-Hassidim-Lloyd (HHL) algorithm (for quantum-gate computers) and the box algorithm (for quantum-annealing…

Computational Engineering, Finance, and Science · Computer Science 2024-05-07 Sanjay Suresh , Krishnan Suresh

Optimization of electricity surplus is a crucial element for transmission power networks to reduce costs and efficiently use the available electricity across the network. In this paper we showed how to optimize such a network with quantum…

Quantum Physics · Physics 2022-12-06 Giuseppe Colucci , Stan van der Linde , Frank Phillipson

Quantum annealing promises to be an effective heuristic for complex NP-hard problems. However, clear demonstrations of quantum advantage are wanting, primarily constrained by the difficulty of embedding the problem into the quantum…

Quantum Physics · Physics 2022-11-15 Minjae Jo , Michael Hanks , M. S. Kim

An important task in multi-objective optimization is generating the Pareto front -- the set of all Pareto-optimal compromises among multiple objective functions applied to the same set of variables. Since this task can be computationally…

Quantum Physics · Physics 2025-11-04 Andrew D. King

The broad applicability of Quadratic Unconstrained Binary Optimization (QUBO) constitutes a general-purpose modeling framework for combinatorial optimization problems and are a required format for gate array and quantum annealing computers.…

Artificial Intelligence · Computer Science 2021-04-06 Amit Verma , Mark Lewis
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