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Controlling and understanding epidemic outbreaks has recently drawn great interest in a large spectrum of research communities. Vaccination is one of the most well-established and effective strategies in order to contain an epidemic. In the…

Social and Information Networks · Computer Science 2023-05-29 Sourin Chatterjee , Ahad N. Zehmakan

Optimal control problems reflecting the finding of effective quarantine strategies are considered for two control SEIR~type models describing the spread of the COVID-19 virus in the human population. The properties of the corresponding…

Optimization and Control · Mathematics 2020-11-30 Ellina Grigorieva , Evgenii Khailov , Andrei Korobeinikov

Effective epidemic control is crucial for mitigating the spread of infectious diseases, particularly when pharmaceutical interventions such as vaccines or treatments are limited. Non-pharmaceutical strategies, including mobility…

Physics and Society · Physics 2025-12-03 Deborah Volpe , Giacomo Orlandi , Mattia Boggio , Carlo Novara , Lorenzo Zino , Giovanna Turvani

We present a detailed set-based analysis of the well-known SIR and SEIR epidemic models subjected to hard caps on the proportion of infective individuals, and bounds on the allowable intervention strategies, such as social distancing,…

Optimization and Control · Mathematics 2021-11-17 Willem Esterhuizen , Jean Lévine , Stefan Streif

In most models of the spread of disease over contact networks it is assumed that the probabilities per unit time of disease transmission and recovery from disease are constant, implying exponential distributions of the time intervals for…

Physics and Society · Physics 2010-07-23 Brian Karrer , M. E. J. Newman

The COVID-19 outbreak has stimulated the interest in the proposal of novel epidemiological models to predict the course of the epidemic so as to help planning effective control strategies. In particular, in order to properly interpret the…

Machine Learning · Computer Science 2021-01-29 Andrea Zugarini , Enrico Meloni , Alessandro Betti , Andrea Panizza , Marco Corneli , Marco Gori

We study the impact of model parameter uncertainty on optimally mitigating the spread of epidemics. We capture the epidemic spreading process using a susceptible-infected-removed (SIR) epidemic model and consider testing for isolation as…

Systems and Control · Electrical Eng. & Systems 2022-09-07 Baike She , Shreyas Sundaram , Philip E. Paré

An epidemic model with births and deaths is considered on a two dimensional LxL lattice. Each individual can have global infective contacts according to the standard SIR model rules or local infective contacts with its nearest neighbors. We…

Populations and Evolution · Quantitative Biology 2015-06-22 Alberto Maltz , Gabriel Fabricius

In this paper, we develop a robust economic model predictive controller for the containment of stochastic Susceptible-Exposed-Infected-Vigilant (SEIV) epidemic processes which drives the process to extinction quickly, while minimizing the…

Optimization and Control · Mathematics 2019-05-14 Nicholas J. Watkins , Cameron Nowzari , George J. Pappas

During pandemic events, strategies such as social distancing can be fundamental to curb viral spreading. Such actions can reduce the number of simultaneous infections and mitigate the disease spreading, which is relevant to the risk of a…

Physics and Society · Physics 2021-02-24 Marco A. Amaral , Marcelo M. de Oliveira , Marco A. Javarone

Mathematical modelling has successfully been used to provide quantitative descriptions of many viral infections, but for the Ebola virus, which requires biosafety level 4 facilities for experimentation, modelling can play a crucial role.…

We propose a mathematical model with five compartments for the SARS-CoV-2 transmission: susceptible $S$, undetected infected asymptomatic $A$, undetected infected symptomatic $I$, confirmed positive and isolated $L$, and recovered $ R$, for…

Optimization and Control · Mathematics 2020-09-29 Gabriela Marinoschi

We consider a SIR model with vaccination strategy on a sparse configuration model random graph. We show the convergence of the system when the number of nodes grows and characterize the scaling limits. Then, we prove the existence of…

Probability · Mathematics 2021-02-26 Emanuel Javier Ferreyra , Matthieu Jonckheere , Juan Pablo Pinasco

We develop a feedback control method for networked epidemic spreading processes. In contrast to most prior works which consider mean field, open-loop control schemes, the present work develops a novel framework for feedback control of…

Optimization and Control · Mathematics 2017-03-23 Nicholas J. Watkins , Cameron Nowzari , George J. Pappas

This paper is concerned with a stochastic model for the spread of an SEIR (susceptible -> exposed (=latent) -> infective -> removed) epidemic with a contact tracing scheme, in which removed individuals may name some of their infectious…

Probability · Mathematics 2015-12-08 Frank G Ball , Edward S Knock , Philip D O'Neill

Our paper investigates distributions of exposed and infectious time periods in an epidemic model and how applying a disease control strategy affects the model's accuracy. While ordinary differential equations are widely used for their…

Populations and Evolution · Quantitative Biology 2018-09-28 Adrienna Bingham , Leah B. Shaw

Contagious diseases can spread quickly in human populations, either through airborne transmission or if some other spreading vectors are abundantly accessible. They can be particularly devastating if the impact on individuals' health has…

Physics and Society · Physics 2022-07-20 Bram A. Siebert , James P. Gleeson , M. Asllani

The SEIR model is a compartmental model used to simulate the dynamics of an epidemic. In this chapter, we introduce two control functions in the compartmental SEIR model representing vaccination and plasma transfusion. Optimal control…

Optimization and Control · Mathematics 2021-07-23 Juliana Couras , Ivan Area , Juan J. Nieto , Cristiana J. Silva , Delfim F. M. Torres

Cost-effectiveness analysis is a mode of determining both the cost and economic health outcomes of one or more control interventions. In this work, we have formulated a non-autonomous nonlinear deterministic model to study the control of…

Waning immunity and reinfection are critical features of many infectious diseases, but epidemiological models often fail to capture the intricate interaction between an individual's history of immunity and their current infection status;…

Populations and Evolution · Quantitative Biology 2026-03-25 Raimund M. Kovacevic , Nikolaos I. Stilianakis , Vladimir M. Veliov