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Tumor recurrence, driven by the evolution of drug resistance is a major barrier to therapeutic success in cancer. Resistance is often caused by genetic alterations such as point mutation, which refers to the modification of a single genomic…

Populations and Evolution · Quantitative Biology 2023-08-23 Aaron Li , Danika Kibby , Jasmine Foo

Coinfection phenomena are common in nature, yet there is a lack of analytical approaches for coinfection systems with a high number of circulating and interacting strains. In this paper, we investigated a coinfection SIS framework applied…

Populations and Evolution · Quantitative Biology 2026-02-06 Sten Madec , Nicola Cinardi , Erida Gjini

Multiple viruses are widely studied because of their negative effect on the health of host as well as on whole population. The dynamics of coinfection is important in this case. We formulated a SIR model that describes the coinfection of…

Dynamical Systems · Mathematics 2019-05-14 Samia Ghersheen , Vladimir Kozlov , Vladimir G. Tkachev , Uno Wennergren

This paper is concerned with a nonlocal dispersal susceptible-infected-susceptible (SIS) epidemic model with Dirichlet boundary condition, where the rates of disease transmission and recovery are assumed to be spatially heterogeneous. We…

Analysis of PDEs · Mathematics 2016-01-21 Fei-Ying Yang , Wan-Tong Li

Real epidemic spreading networks often composed of several kinds of networks interconnected with each other, and the interrelated networks have the different topologies and epidemic dynamics. Moreover, most human diseases are derived from…

Physics and Society · Physics 2017-06-21 Zhongpu Xu , Xinchu Fu

Recent years have seen a large amount of interest in epidemics on networks as a way of representing the complex structure of contacts capable of spreading infections through the modern human population. The configuration model is a popular…

Populations and Evolution · Quantitative Biology 2017-01-23 Frank Ball , Thomas House

We show that the simplest stochastic epidemiological models with spatial correlations exhibit two types of oscillatory behaviour in the endemic phase. In a large parameter range, the oscillations are due to resonant amplification of…

Populations and Evolution · Quantitative Biology 2009-06-02 Ganna Rozhnova , Ana Nunes

In mathematical studies of the dynamics of multi-strain diseases caused by antigenically diverse pathogens, there is a substantial interest in analytical insights. Using the example of a generic model of multi-strain diseases with…

Chaotic Dynamics · Physics 2015-11-13 K. B. Blyuss

The evolutionary effect of recombination depends crucially on the epistatic interactions between linked loci. A paradigmatic case where recombination is known to be strongly disadvantageous is a two-locus fitness landscape dis- playing…

Populations and Evolution · Quantitative Biology 2012-02-13 Su-Chan Park , Joachim Krug

Crime remains one of the significant problems that countries are grappling with globally. With shrinking economies and increasing poverty, crime has been on the rise in many countries. In this paper, we propose a system of non-linear…

Dynamical Systems · Mathematics 2024-10-15 Zeray H. Gebrezabher , Deniz Eroglu

Mathematical disease modelling has long operated under the assumption that any one infectious disease is caused by one transmissible pathogen spreading among a population. This paradigm has been useful in simplifying the biological reality…

Populations and Evolution · Quantitative Biology 2021-06-02 Blake J. M. Williams , Guillaume St-Onge , Laurent Hébert-Dufresne

Understanding the spread of diseases through complex networks is of great interest where realistic, heterogeneous contact patterns play a crucial role in the spread. Most works have focused on mean-field behavior -- quantifying how contact…

Statistical Mechanics · Physics 2022-12-14 Elad Korngut , Jason Hindes , Michael Assaf

Two versions of the susceptible-infected-susceptible epidemic model, which have different transmission rules, are analysed. Both models are considered on a weighted network to simulate a mitigation in the connection between the individuals.…

Statistical Mechanics · Physics 2021-02-10 C. Dias , M. O. Hase

A two-state epidemic model in networks with links mimicking two kinds of relationships between connected nodes is introduced. Links of weights w1 and w0 occur with probabilities p and 1-p, respectively. The fraction of infected nodes rho(p)…

Physics and Society · Physics 2015-08-26 Elvis H. W. Xu , Wei Wang , C. Xu , Ming Tang , Younghae Do , P. M. Hui

We propose a game-theoretic dynamics of a population of replicating individuals. It consists of two parts: the standard replicator one and a migration between two different habitats. We consider symmetric two-player games with two…

Populations and Evolution · Quantitative Biology 2007-05-23 Jacek Miekisz , Tadeusz Platkowski

Network-based models of epidemic spread have become increasingly popular in recent decades. Despite a rich foundation of such models, few low-dimensional systems for modeling SIS-type diseases have been proposed that manage to capture the…

Dynamical Systems · Mathematics 2021-01-01 Carl Corcoran , Alan Hastings

Doubly robust (DR) estimation is a crucial technique in causal inference and missing data problems. We propose a novel Propensity score Augmentved Doubly robust (PAD) estimator to enhance the commonly used DR estimator for average treatment…

Methodology · Statistics 2023-04-18 Liangbo Lyu , Molei Liu

We present a continuous formulation of epidemic spreading on multilayer networks using a tensorial representation, extending the models of monoplex networks to this context. We derive analytical expressions for the epidemic threshold of the…

Bacterial resistance to antibiotic treatment is a huge concern: introduction of any new antibiotic is shortly followed by the emergence of resistant bacterial isolates in the clinic. This issue is compounded by a severe lack of new…

Cell Behavior · Quantitative Biology 2014-09-16 Lucy Ternent , Rosemary J. Dyson , Anne-Marie Krachler , Sara Jabbari

The basic reproduction number, $R_0$, is a well-known quantifier of epidemic spread. However, a class of existing methods for estimating $R_0$ from incidence data early in the epidemic can lead to an over-estimation of this quantity. In…

Populations and Evolution · Quantitative Biology 2024-03-27 Wajid Ali , Christopher E. Overton , Robert R. Wilkinson , Kieran J. Sharkey