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Related papers: Ptychographic modulation engine (PME): a low-cost …

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Background: Tumour budding is an independent predictor of metastasis and prognosis in colorectal cancer and is a vital part of the pathology specification report. In a conventional pathological section observation process, pathologists have…

Medical Physics · Physics 2025-03-21 Yiyan Su , Ruiqing Sun , Yajing Wang , Yanfeng xi , Shaohui Zhang

Microscopes face a trade-off between spatial resolution, field-of-view, and frame rate -- improving one of these properties typically requires sacrificing the others, due to the limited spatiotemporal throughput of the sensor. To overcome…

Capturing biological specimens at large scales with sub-micron resolution is crucial for biomedical research, but conventional cameras often can't handle the pixel requirements. While most microscopes use motorized stages to move samples…

Optics · Physics 2025-03-28 Charlie Kersuzan , Aymerick Bazin , Amaury Badon

Ptychography is a lensless imaging method that allows for wavefront sensing and phase-sensitive microscopy from a set of diffraction patterns. Recently, it has been shown that the optimization task in ptychography can be achieved via…

Image and Video Processing · Electrical Eng. & Systems 2021-01-13 Jacob Seifert , Dorian Bouchet , Lars Loetgering , Allard P. Mosk

Ptychography is an imaging technique that enables nanometer-scale reconstruction of complex transmittance images by scanning objects with overlapping illumination patterns. However, the illumination function is typically unknown, which…

Image and Video Processing · Electrical Eng. & Systems 2025-01-14 Qiuchen Zhai , Gregery T. Buzzard , Kevin Mertes , Brendt Wohlberg , Charles A. Bouman

Ptychographic extreme ultraviolet (EUV) diffractive imaging has emerged as a promising candidate for the next-generation metrology solutions in the semiconductor industry, as it can image wafer samples in reflection geometry at the…

Image and Video Processing · Electrical Eng. & Systems 2023-11-28 Yifeng Shao , Sven Weerdenburg , Jacob Seifert , H. Paul Urbach , Allard P. Mosk , Wim Coene

Multislice electron ptychography (MEP) is an inverse imaging technique that computationally reconstructs the highest-resolution images of atomic crystal structures from diffraction patterns. Available algorithms often solve this inverse…

Image and Video Processing · Electrical Eng. & Systems 2025-07-28 Christian K. Belardi , Chia-Hao Lee , Yingheng Wang , Justin Lovelace , Kilian Q. Weinberger , David A. Muller , Carla P. Gomes

We demonstrate a new scheme of spectromicroscopy in the extreme ultraviolet (EUV) spectral range, where the spectral response of the sample at different wavelengths is imaged simultaneously. It is enabled by applying ptychographical…

Fourier ptychographic microscopy (FPM) is a promising quantitative phase imaging technique that enables high-resolution, label-free imaging over a large field-of-view. Here, we present the first application of FPM for the quantitative…

Small-molecule drug discovery requires simultaneous optimization of numerous properties of candidate molecules. These properties can be investigated through the analysis of high-dimensional biological signatures, such as cell morphology and…

Machine Learning · Computer Science 2026-05-28 Łukasz Janisiów , Sebastian Musiał , Bartosz Zieliński , Dawid Rymarczyk , Tomasz Danel

The photoacoustic (PA) effect consisting of the generation of an acoustic signal based on the absorption of light has already demonstrated its potential for various spectroscopic applications for both gaseous and solid samples. The signal…

Computational Physics · Physics 2018-10-30 Said El-Busaidy , Bernd Baumann , Marcus Wolff , Lars Duggen

Over the past few years, the combination of diffuser and near-field electron ptychography has drawn more attention by its ability to recover large field of view with few diffraction patterns. In this paper, we purpose a novel design and…

Photoelectrochemical (PEC) biosensors exhibit significant potential for biomolecule detection due to their high sensitivity and low background noise. However, their performance is severely constrained by the rapid recombination of…

Accurate lesion segmentation in ultrasound images is essential for preventive screening and clinical diagnosis, yet remains challenging due to low contrast, blurry boundaries, and significant scale variations. Although existing deep…

Computer Vision and Pattern Recognition · Computer Science 2026-04-16 Chen Wang , Yixin Zhu , Yongbin Zhu , Fengyuan Shi , Qi Li , Jun Wang , Zuozhu Liu , Keli Hu

Coherent microscopy techniques provide an unparalleled multi-scale view of materials across scientific and technological fields, from structural materials to quantum devices, from integrated circuits to biological cells. Driven by the…

Labelfree nanoscopy encompasses optical imaging with resolution in the 100 nm range using visible wavelengths. Here, we present a labelfree nanoscopy method that combines Fourier ptychography with waveguide microscopy to realize a…

Automated label-free quantitative imaging of biological samples can greatly benefit high throughput diseases diagnosis. Digital holographic microscopy (DHM) is a powerful quantitative label-free imaging tool that retrieves structural…

Ptychography is a data-intensive computational imaging technique that achieves high spatial resolution over large fields of view. The technique involves scanning a coherent beam across overlapping regions and recording diffraction patterns.…

Image and Video Processing · Electrical Eng. & Systems 2025-05-14 Refik Mert Cam , Junjing Deng , Rajkumar Kettimuthu , Mathew J. Cherukara , Tekin Bicer

Ptychography is a promising phase retrieval technique for label-free quantitative phase imaging. Recent advances in phase retrieval algorithms witnessed the development of spectral methods, in order to accelerate gradient descent…

Optics · Physics 2021-04-07 Lorenzo Valzania , Jonathan Dong , Sylvain Gigan

A novel device that can be used as a tunable support-free phase plate for transmission electron microscopy of weakly scattering specimens is described. The device relies on the generation of a controlled phase shift by the magnetic field of…