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Protein crystal production is a major bottleneck for the structural characterisation of proteins. To advance beyond large-scale screening, rational strategies for protein crystallization are crucial. Understanding how chemical anisotropy…

Biomolecules · Quantitative Biology 2022-05-03 Amir R. Khan , Susan James , Michelle K. Quinn , Irem Altan , Patrick Charbonneau , Jennifer J. McManus

Hypothesis Roughening transitions at solid-liquid interfaces govern crystal morphology in diverse systems. In ice crystallization, these transitions control interfacial faceting and surface kinetics. Faceted morphologies are often…

Materials Science · Physics 2025-08-26 Jorge H. Melillo , Ido Braslavsky

Molecular dynamics simulations have revealed a dramatic increase, with increasing temperature, of the amplitude of electrostatic fluctuations caused by water at the active site of metalloprotein plastocyanin. The increased breadth of…

Biological Physics · Physics 2009-11-13 David N. LeBard , Dmitry V. Matyushov

The morphology of water ice in the interstellar medium is still an open question. Although accretion of gaseous water could not be the only possible origin of the observed icy mantles covering dust grains in cold molecular clouds, it is…

A comprehensive, semi-quantitative model for the thermodynamics of hydrophobic solvation is presented. The model is based on a very simple premise suggested by the scaled particle theory and treats both solute and solvent molecules as hard…

Biological Physics · Physics 2007-05-23 Hong Qian

We address the problem of inverse polymer swelling. This phenomenon, in which a collapsed polymer chain swells upon decreasing temperature, can be observed experimentally in so-called thermoreversible homopolymers in aqueous solution, and…

Soft Condensed Matter · Physics 2007-05-23 Marco Pretti

Unstructured proteins can modulate cellular responses to environmental conditions by undergoing coil-globule transitions and phase separation. However, the molecular mechanisms of these phenomena still need to be fully understood. Here, we…

Soft Condensed Matter · Physics 2023-06-28 Bernat Durà Faulí , Valentino Bianco , Giancarlo Franzese

We elucidate the mechanism of cold denaturation through constant-pressure simulations for a model of hydrophobic molecules in an explicit solvent. We find that the temperature dependence of the hydrophobic effect is the driving…

Soft Condensed Matter · Physics 2009-11-13 Cristiano L. Dias , Tapio Ala-Nissila , Mikko Karttunen , Ilpo Vattulainen , Martin Grant

Photochromic diarylethene is known to exhibit reversible photoisomerization under irradiation with ultraviolet (UV) and visible light. Besides reversible optical properties upon light irradiation, a variety of discontinuous morphological…

In this article, we demonstrate a method for inducing reversible crystal-to-crystal transitions in binary mixtures of soft colloidal particles. Through a controlled decrease of salinity and increasingly dominating electrostatic…

Soft Condensed Matter · Physics 2021-08-30 Jasper N. Immink , Maxime J. Bergman , J. J. Erik Maris , Joakim Stenhammar , Peter Schurtenberger

A theoretical approach is developed to quantify hydrophobic hydration and interactions on a molecular scale, with the goal of gaining insight into the molecular origins of hydrophobic effects. The model is based on the fundamental relation…

Chemical Physics · Physics 2016-08-15 G. Hummer , S. Garde , A. E. García , M. E. Paulaitis , L. R. Pratt

Structural symmetry of crystals plays important roles in physical properties of two-dimensional (2D) materials, particularly in the nonlinear optics regime. It has been a long-term exploration on the physical properties in 2D materials with…

Microgels are often discussed as well-suited model system for soft colloids. In contrast to rigid spheres, the microgel volume and, coupled to this, the volume fraction in dispersion can be manipulated by external stimuli. This behavior is…

We report applications of analytical formalisms and Molecular Dynamics (MD) simulations to the calculation of redox entropy of plastocyanin metalloprotein in aqueous solution. The goal of our analysis is to establish critical components of…

Biological Physics · Physics 2009-11-13 David N. LeBard , Dmitry V. Matyushov

An intriguing phenomenon displayed by granular flows and predicted by kinetic-theory-based models is the instability known as particle "clustering," which refers to the tendency of dissipative grains to form transient, loose regions of…

Statistical Mechanics · Physics 2012-04-17 Peter P. Mitrano , Vicente Garzó , Andrew M. Hilger , Christopher J. Ewasko , Christine M. Hrenya

Water has many anomalous properties compared to "simple" liquids, and these anomalies are typically enhanced in supercooled water. While numerous models have been proposed, including the liquid-liquid critical point, the singularity-free…

Chemical Physics · Physics 2020-10-28 Loni Kringle , Wyatt A. Thornley , Bruce D. Kay , Greg A. Kimmel

We report the first observation of temperature-controlled reentrant transition in simulations of mixtures of small and big particles interacting via soft repulsive potential in 2D. As temperature increases, the system passes from a fluid…

Soft Condensed Matter · Physics 2022-04-13 Itay Azizi , Alexander Y. Grosberg , Yitzhak Rabin

We study 2D solids with weak substrate disorder, using Coulomb gas renormalisation. The melting transition is found to be replaced by a sharp crossover between a high $T$ liquid with thermally induced dislocations, and a low $T$ glassy…

Disordered Systems and Neural Networks · Physics 2009-10-30 David Carpentier , Pierre Le Doussal

We use molecular dynamics simulations in two dimensions to investigate the possibility that a core-softened potential can reproduce static and dynamic anomalies found experimentally in liquid water: (i) the increase in specific volume upon…

Soft Condensed Matter · Physics 2009-10-31 A. Scala , M. Reza Sadr-Lahijany , N. Giovambattista , S. V. Buldyrev , H. E. Stanley

We investigate the variation of the driving force for crystallization of a supercooled liquid along isomorphs, curves along which structure and dynamics are invariant. The variation is weak, and can be predicted accurately for the…

Statistical Mechanics · Physics 2017-06-23 Ulf R. Pedersen , Karolina Adrjanowicz , Kristine Niss , Nicholas P. Bailey
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