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This work studies the properties of the maximum likelihood estimator (MLE) of a non-linear model with Gaussian errors and multidimensional parameter. The observations are collected in a two-stage experimental design and are dependent since…

Statistics Theory · Mathematics 2019-11-01 Nancy Flournoy , Caterina May , Chiara Tommasi

Debiased machine learning estimators for smooth functionals in nonparametric models can exhibit substantial variability and instability, often leading practitioners to instead rely on parametric or semiparametric working models. Such…

Methodology · Statistics 2026-03-20 Lars van der Laan , Marco Carone , Alex Luedtke , Mark van der Laan

The paper proposes a systematic framework for building data-driven stochastic differential equation (SDE) models from sparse, noisy observations. Unlike traditional parametric approaches, which assume a known functional form for the drift,…

Machine Learning · Statistics 2025-08-18 Arnab Ganguly , Riten Mitra , Jinpu Zhou

Purpose: We address the challenge of inaccurate parameter estimation in diffusion MRI when the signal-to-noise ratio (SNR) is very low, as in the spinal cord. The accuracy of conventional maximum-likelihood estimation (MLE) depends highly…

This note extends the results of classical parametric statistics like Fisher and Wilks theorem to modern setups with a high or infinite parameter dimension, limited sample size, and possible model misspecification. We consider a special…

Statistics Theory · Mathematics 2025-06-09 Vladimir Spokoiny

Due to developments in instruments and computers, functional observations are increasingly popular. However, effective methodologies for flexibly estimating the underlying trends with valid uncertainty quantification for a sequence of…

Methodology · Statistics 2022-09-22 Tomoya Wakayama , Shonosuke Sugasawa

This paper considers a multi-environment linear regression model in which data from multiple experimental settings are collected. The joint distribution of the response variable and covariates may vary across different environments, yet the…

Statistics Theory · Mathematics 2024-12-03 Jianqing Fan , Cong Fang , Yihong Gu , Tong Zhang

Additive smooth models, such as Generalized additive models (GAMs) of location, scale, and shape (GAMLSS), are a popular choice for modeling experimental data. However, software available to fit such models is usually not tailored…

Methodology · Statistics 2025-06-17 Joshua Krause , Jelmer P. Borst , Jacolien van Rij

High-dimensional functional data have become increasingly prevalent in modern applications such as high-frequency financial data and neuroimaging data analysis. We investigate a class of high-dimensional linear regression models, where each…

Methodology · Statistics 2025-11-06 Xingche Guo , Yehua Li , Tailen Hsing

Given $n$ noisy samples with $p$ dimensions, where $n \ll p$, we show that the multi-step thresholding procedure based on the Lasso -- we call it the {\it Thresholded Lasso}, can accurately estimate a sparse vector $\beta \in {\mathbb R}^p$…

Statistics Theory · Mathematics 2025-10-28 Shuheng Zhou

The Active Subspace (AS) method is a widely used technique for identifying the most influential directions in high-dimensional input spaces that affect the output of a computational model. The standard AS algorithm requires a sufficient…

Numerical Analysis · Mathematics 2025-10-24 Fabio Nobile , Matteo Raviola , Raul Tempone

Sharpness-aware minimization (SAM) seeks the minima with a flat loss landscape to improve the generalization performance in machine learning tasks, including fine-tuning. However, its extra parameter perturbation step doubles the…

Machine Learning · Computer Science 2026-02-11 Yifei Cheng , Xianglin Yang , Guoxia Wang , Chao Huang , Fei Ma , Dianhai Yu , Xiaochun Cao , Li Shen

A recently proposed SLOPE estimator (arXiv:1407.3824) has been shown to adaptively achieve the minimax $\ell_2$ estimation rate under high-dimensional sparse linear regression models (arXiv:1503.08393). Such minimax optimality holds in the…

Machine Learning · Statistics 2021-09-24 Shuaiwen Wang , Haolei Weng , Arian Maleki

Unlike the ordinary least-squares (OLS) estimator for the linear model, a ridge regression linear model provides coefficient estimates via shrinkage, usually with improved mean-square and prediction error. This is true especially when the…

Methodology · Statistics 2015-06-25 George Karabatsos

We address numerical differentiation under coarse, non-uniform sampling and Gaussian noise. A maximum-likelihood estimator with $L_2$-norm constraint on a higher-order derivative is obtained, yielding spline-based solution. We introduce a…

Methodology · Statistics 2025-07-31 Konstantin E. Avrachenkov , Leonid B. Freidovich

We present a static analysis for discovering differentiable or more generally smooth parts of a given probabilistic program, and show how the analysis can be used to improve the pathwise gradient estimator, one of the most popular methods…

Programming Languages · Computer Science 2022-11-15 Wonyeol Lee , Xavier Rival , Hongseok Yang

In high dimensional sparse regression, pivotal estimators are estimators for which the optimal regularization parameter is independent of the noise level. The canonical pivotal estimator is the square-root Lasso, formulated along with its…

Machine Learning · Statistics 2020-09-04 Mathurin Massias , Quentin Bertrand , Alexandre Gramfort , Joseph Salmon

Targeted maximum likelihood estimation (TMLE) is a general method for estimating parameters in semiparametric and nonparametric models. Each iteration of TMLE involves fitting a parametric submodel that targets the parameter of interest. We…

Methodology · Statistics 2014-06-03 Iván Díaz , Michael Rosenblum

We develop a general framework for estimating function-valued parameters under equality or inequality constraints in infinite-dimensional statistical models. Such constrained learning problems are common across many areas of statistics and…

Machine Learning · Statistics 2025-07-22 Razieh Nabi , Nima S. Hejazi , Mark J. van der Laan , David Benkeser

When the data are sparse, optimization of hyperparameters of the kernel in Gaussian process regression by the commonly used maximum likelihood estimation (MLE) criterion often leads to overfitting. We show that choosing hyperparameters (in…

Methodology · Statistics 2023-01-27 Sergei Manzhos , Manabu Ihara