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Antibodies and humoral memory are key components of the adaptive immune system. We consider and computationally model mechanisms by which humoral memory present at baseline might instead increase infection load; we refer to this effect as…
Pain is a significant global health issue, and the current treatment options for pain management have limitations in terms of effectiveness, side effects, and potential for addiction. There is a pressing need for improved pain treatments…
This paper presents a versatile cable-driven robotic interface to investigate the single-joint joint neuromechanics of the hip, knee and ankle. This endpoint-based interface offers highly dynamic interaction and accurate position control,…
We consider the information transmission problem in neurons and its possible implications for learning in neural networks. Our approach is based on recent developments in statistical physics and complexity science. Combining sensory…
Mitochondrial diseases are currently untreatable due to our limited understanding of their pathology. We study the expression of various mitochondrial proteins in skeletal myofibres (SM) in order to discover processes involved in…
Focal cortical dysplasia (FCD) type II is a major cause of drug-resistant epilepsy, often curable only by surgery. Despite its clinical importance, the diagnosis of FCD is very difficult in MRI because of subtle abnormalities, leading to…
The prediction of protein interactions (CPIs) is crucial for the in-silico screening step in drug discovery. Recently, many end-to-end representation learning methods using deep neural networks have achieved significantly better performance…
Experiments show that spike-triggered stimulation performed with Bidirectional Brain-Computer-Interfaces (BBCI) can artificially strengthen connections between separate neural sites in motor cortex (MC). What are the neuronal mechanisms…
The identification of compound-protein interactions (CPI) plays a critical role in drug screening, drug repurposing, and combination therapy studies. The effectiveness of CPI prediction relies heavily on the features extracted from both…
Developments in Brain Computer Interfaces (BCIs) are empowering those with severe physical afflictions through their use in assistive systems. Common methods of achieving this is via Motor Imagery (MI), which maps brain signals to code for…
The specific connectivity of a neuronal network is reflected in the dynamics of the signals recorded on its nodes. The analysis of how the activity in one node predicts the behaviour of another gives the directionality in their…
Impulsive individuals exhibit abnormal reward processing (heightened preference for immediate rewards, i.e., impulsive choice, IC) and a penchant for maladaptive action (the inability to inhibit inappropriate actions, i.e., impulsive…
The importance of understanding the mechanism of protein aggregation into insoluble amyloid fibrils relies not only on its medical consequences, but also on its more basic properties of self--organization. The discovery that a large number…
Intrinsically disordered proteins (IDPs) and proteins with intrinsically disordered regions (IDRs) govern a daunting number of physiological processes. For such proteins, molecular mechanisms governing their interactions with proteins…
High-dimensional tissue imaging generates highly complex 3D data containing multiple biomarkers, making it challenging to identify biologically relevant regions without an expert user specifying manual labels for regions of interest. We…
Fibronectin, a glycoprotein secreted by connective tissue cells is found in the human plasma as well as in the ECM. It is known to have an adhesive property and plays a role in cell-to-cell and cell-to-substratum adhesions. In rheumatoid…
Structural and functional MRI studies of patients with post-stroke language deficits have contributed substantially to our understanding of how cognitive-behavioral impairments relate to the location of structural damage and to the…
Various theoretical studies have been carried out to infer relevant protein-protein interactions among pathogens and their hosts. Such studies are generally based on preferential attachment of bacteria / virus to their human receptor…
Inflammatory bowel diseases (IBD) are complex diseases in which the gut microbiota is attacked by the immune system of genetically predisposed subjects when they are exposed to yet unclear environmental factors. The complexity of this class…
The predominant structural protein in vertebrates is collagen, which plays a key role in extracellular matrix and connective tissue mechanics. Despite its prevalence and physical importance in biology, the mechanical properties of molecular…