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An oritatami system (OS) is a theoretical model of self-assembly via co-transcriptional folding. It consists of a growing chain of beads which can form bonds with each other as they are transcribed. During the transcription process, the…

Data Structures and Algorithms · Computer Science 2018-07-16 Erik D. Demaine , Jacob Hendricks , Meagan Olsen , Matthew J. Patitz , Trent A. Rogers , Nicolas Schabanel , Shinnosuke Seki , Hadley Thomas

We study the oritatami model for molecular co-transcriptional folding. In oritatami systems, the transcript (the "molecule") folds as it is synthesized (transcribed), according to a local energy optimisation process, which is similar to how…

Computational Geometry · Computer Science 2018-07-16 Cody Geary , Pierre-Étienne Meunier , Nicolas Schabanel , Shinnosuke Seki

Computational prediction of RNA structures is an important problem in computational structural biology. Studies of RNA structure formation often assume that the process starts from a fully synthesized sequence. Experimental evidence,…

Biomolecules · Quantitative Biology 2021-04-28 Vo Hong Thanh , Dani Korpela , Pekka Orponen

With the help of a mathematical model, the metabolic process of the Krebs cycle is studied. The autocatalytic processes resulting in both the formation of the self-organization in the Krebs cycle and the appearance of a cyclicity of its…

Molecular Networks · Quantitative Biology 2017-10-26 V. I. Grytsay , I. V. Musatenko

Automatically creating a computer program using input-output examples can be a challenging task, especially when trying to synthesize computer programs that require loops or recursion. Even though the use of recursion can make the…

Programming Languages · Computer Science 2024-06-04 Matheus Campos Fernandes , Fabrício Olivetti de França , Emilio Francesquini

It is the first step for understanding how RNA structure folds from base sequences that to know how its secondary structure is formed. Traditional energy-based algorithms are short of precision, particularly for non-nested sequences, while…

Quantum Physics · Physics 2023-05-18 Ji Jiang , Qipeng Yan , Ye Li , Min Lu , Ziwei Cui , Menghan Dou , Qingchun Wang , Yu-Chun Wu , Guo-Ping Guo

The kinetic folding of RNA sequences into secondary structures is modeled as a complex adaptive system, the components of which are possible RNA structural rearrangements (SRs) and their associated bases and base pairs. RNA bases and base…

Biomolecules · Quantitative Biology 2007-05-23 Wilfred Ndifon

In this lecture we present an overview of the physics of irreversible fractal growth process, with particular emphasis on a class of models characterized by {\em quenched disorder}. These models exhibit self-organization, with critical…

Statistical Mechanics · Physics 2007-05-23 L. Pietronero , R. Cafiero , A. Gabrielli

Complex-dynamical fractal is a hierarchy of permanently, chaotically changing versions of system structure, obtained as the unreduced, causally probabilistic general solution of arbitrary interaction problem (physics/0305119,…

General Physics · Physics 2007-05-23 Andrei P. Kirilyuk

Analysis and modeling of networked objects are fundamental pieces of modern data mining. Most real-world networks, from biological to social ones, are known to have common structural properties. These properties allow us to model the growth…

Data Structures and Algorithms · Computer Science 2016-09-27 Takuya Akiba , Kenko Nakamura , Taro Takaguchi

RNA co-transcriptionality, where RNA is spliced or folded during transcription from DNA templates, offers promising potential for molecular programming. It enables programmable folding of nano-scale RNA structures and has recently been…

Formal Languages and Automata Theory · Computer Science 2025-07-01 Da-Jung Cho , Szilárd Zsolt Fazekas , Shinnosuke Seki , Max Wiedenhöft

The computer-aided folding of biomolecules, particularly RNAs, is one of the most difficult challenges in computational structural biology. RNA tetraloops are fundamental RNA motifs playing key roles in RNA folding and RNA-RNA and…

Biomolecules · Quantitative Biology 2016-09-28 Petra Kührová , Robert B. Best , Sandro Bottaro , Giovanni Bussi , Jiří Šponer , Michal Otyepka , Pavel Banáš

The folding of RNA and DNA strands plays crucial roles in biological systems and bionanotechnology. However, studying these processes with high-resolution numerical models is beyond current computational capabilities due to the timescales…

Soft Condensed Matter · Physics 2024-02-07 F. Tosti Guerra , E. Poppleton , P. Šulc , L. Rovigatti

Orbital magnetization (OM) in Sierpinski carpet (SC) and triangle (ST) fractal is theoretically investigated by using Haldane model as a prototypical example. The OM calculation is performed following two distinct approaches; employing the…

Materials Science · Physics 2026-03-30 L. L. Lage , Tarik. P. Cysne , A. Latgé

Motivation: Predicting the secondary structure of an RNA sequence is useful in many applications. Existing algorithms (based on dynamic programming) suffer from a major limitation: their runtimes scale cubically with the RNA length, and…

Biomolecules · Quantitative Biology 2020-01-14 Liang Huang , He Zhang , Dezhong Deng , Kai Zhao , Kaibo Liu , David A. Hendrix , David H. Mathews

Ribonucleic Acid (RNA) can fold into shapes that perform functions in the cell. These foldings are governed by Watson-Crick base pairing, namely Adenine to Uracil and Cytosine to Guanine (A-U and G-C). The properties of the H-P…

Combinatorics · Mathematics 2018-12-18 Ben Y. Maron

It is commonly believed in the literature that smooth curves, such as circles, are not fractal, and only non-smooth curves, such as coastlines, are fractal. However, this paper demonstrates that a smooth curve can be fractal, under the new,…

General Mathematics · Mathematics 2020-09-04 Ding Ma , Bin Jiang

We construct meta-intransitive systems of independent random variables of any finite order from basic tuple of random variables which generalize intransitive dice. Under this construction, the equality of some linear functional is…

Probability · Mathematics 2024-05-07 Alexey V. Lebedev

The Sierpinski Triangle (ST) is a fractal mathematical structure that has been used to explore the emergence of flat bands in lattices of different geometries and dimensions in condensed matter. Here we look into fractal features in the…

Mesoscale and Nanoscale Physics · Physics 2024-11-08 L. L. Lage , A. Latge

RNAs self-interact through hydrogen-bond base-pairing between nucleotides and fold into specific, stable structures that substantially govern their biochemical behaviour. Experimental characterization of these structures remains difficult,…

Quantum Physics · Physics 2023-05-02 Tristan Zaborniak , Juan Giraldo , Hausi Müller , Hosna Jabbari , Ulrike Stege
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