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A major cause of irreversible visual impairment is angle-closure glaucoma, which can be screened through imagery from Anterior Segment Optical Coherence Tomography (AS-OCT). Previous computational diagnostic techniques address this…

Computer Vision and Pattern Recognition · Computer Science 2018-09-11 Huazhu Fu , Yanwu Xu , Stephen Lin , Damon Wing Kee Wong , Baskaran Mani , Meenakshi Mahesh , Tin Aung , Jiang Liu

Optical Coherence Tomography (OCT) is essential for diagnosing conditions such as glaucoma, diabetic retinopathy, and age-related macular degeneration. Accurate retinal layer segmentation enables quantitative biomarkers critical for…

Image and Video Processing · Electrical Eng. & Systems 2025-09-10 S M Asiful Islam Saky , Ugyen Tshering

Objective: The advent of Electronic Medical Records (EMR) with large electronic imaging databases along with advances in deep neural networks with machine learning has provided a unique opportunity to achieve milestones in automated image…

Machine Learning · Statistics 2016-12-16 Cecilia S. Lee , Doug M. Baughman , Aaron Y. Lee

The treatment of age-related macular degeneration (AMD) requires continuous eye exams using optical coherence tomography (OCT). The need for treatment is determined by the presence or change of disease-specific OCT-based biomarkers.…

Image and Video Processing · Electrical Eng. & Systems 2026-03-12 Timo Kepp , Helge Sudkamp , Claus von der Burchard , Hendrik Schenke , Peter Koch , Gereon Hüttmann , Johann Roider , Mattias P. Heinrich , Heinz Handels

Automatic motion compensation and adjustment of an intraoperative imaging modality's field of view is a common problem during interventions. Optical coherence tomography (OCT) is an imaging modality which is used in interventions due to its…

Computer Vision and Pattern Recognition · Computer Science 2019-03-12 Nils Gessert , Martin Gromniak , Matthias Schlüter , Alexander Schlaefer

This study introduces the Hybrid Multi-modal VGG (HM-VGG) model, a cutting-edge deep learning approach for the early diagnosis of glaucoma. The HM-VGG model utilizes an attention mechanism to process Visual Field (VF) data, enabling the…

Image and Video Processing · Electrical Eng. & Systems 2024-11-01 Junliang Du , Yiru Cang , Tong Zhou , Jiacheng Hu , Weijie He

Glaucoma, a leading cause of irreversible blindness, necessitates early detection for accurate and timely intervention to prevent irreversible vision loss. In this study, we present a novel deep learning framework that leverages the…

Image and Video Processing · Electrical Eng. & Systems 2025-09-05 Mona Ashtari-Majlan , David Masip

Glaucoma is a major eye disease, leading to vision loss in the absence of proper medical treatment. Current diagnosis of glaucoma is performed by ophthalmologists who are often analyzing several types of medical images generated by…

Computer Vision and Pattern Recognition · Computer Science 2019-04-05 Mijung Kim , Olivier Janssens , Ho-min Park , Jasper Zuallaert , Sofie Van Hoecke , Wesley De Neve

Automated optic disc (OD) and optic cup (OC) segmentation in fundus images is relevant to efficiently measure the vertical cup-to-disc ratio (vCDR), a biomarker commonly used in ophthalmology to determine the degree of glaucomatous optic…

Ophthalmic diseases represent a significant global health issue, necessitating the use of advanced precise diagnostic tools. Optical Coherence Tomography (OCT) imagery which offers high-resolution cross-sectional images of the retina has…

Artificial Intelligence · Computer Science 2024-09-27 Md. Touhidul Islam , Md. Abtahi Majeed Chowdhury , Mahmudul Hasan , Asif Quadir , Lutfa Aktar

Although unprecedented sensitivity and specificity values are reported, recent glaucoma detection deep learning models lack in decision transparency. Here, we propose a methodology that advances explainable deep learning in the field of…

Image and Video Processing · Electrical Eng. & Systems 2021-10-06 Ruben Hemelings , Bart Elen , João Barbosa-Breda , Matthew B. Blaschko , Patrick De Boever , Ingeborg Stalmans

Retinal neovascularization (RNV) is a vision threatening development in diabetic retinopathy (DR). Vision loss associated with RNV is preventable with timely intervention, making RNV clinical screening and monitoring a priority. Optical…

Image and Video Processing · Electrical Eng. & Systems 2026-04-01 Jinyi Hao , Jie Wang , Liqin Gao , Tristan T. Hormel , Yukun Guo , An-Lun Wu , Christina J. Flaxel , Steven T. Bailey , Kotaro Tsuboi , Thomas S. Hwang , Yali Jia

In medical science, the use of computer science in disease detection and diagnosis is gaining popularity. Previously, the detection of disease used to take a significant amount of time and was less reliable. Machine learning (ML) techniques…

Image and Video Processing · Electrical Eng. & Systems 2019-12-18 Nowshin Tasnim , Mahmudul Hasan , Ishrak Islam

Our objective is to evaluate the efficacy of methods that use deep learning (DL) for the automatic fine-grained segmentation of optical coherence tomography (OCT) images of the retina. OCT images from 10 patients with mild non-proliferative…

Computer Vision and Pattern Recognition · Computer Science 2018-01-31 Mike Pekala , Neil Joshi , David E. Freund , Neil M. Bressler , Delia Cabrera DeBuc , Philippe M Burlina

Objective: (1) To assess whether ONH biomechanics improves prediction of three progressive visual field loss patterns in glaucoma; (2) to use explainable AI to identify strain-sensitive ONH regions contributing to these predictions.…

Purpose: To develop the first 3D optic nerve head (ONH) atlas using AI-based registration and evaluate its use in: (1) atlas-adjusted retinal nerve fiber layer (RNFL) analysis for glaucoma diagnosis, and (2) strain-based assessment of…

Given that the neural and connective tissues of the optic nerve head (ONH) exhibit complex morphological changes with the development and progression of glaucoma, their simultaneous isolation from optical coherence tomography (OCT) images…

Glaucoma leads to permanent vision disability by damaging the optical nerve that transmits visual images to the brain. The fact that glaucoma does not show any symptoms as it progresses and cannot be stopped at the later stages, makes it…

Image and Video Processing · Electrical Eng. & Systems 2021-09-29 Ozer Can Devecioglu , Junaid Malik , Turker Ince , Serkan Kiranyaz , Eray Atalay , Moncef Gabbouj

Since the introduction of optical coherence tomography (OCT), it has been possible to study the complex 3D morphological changes of the optic nerve head (ONH) tissues that occur along with the progression of glaucoma. Although several deep…

Optical Coherence Tomography Angiography (OCTA) and its derived en-face projections provide high-resolution visualization of the retinal and choroidal vasculature, which is critical for the rapid and accurate diagnosis of retinal diseases.…

Computer Vision and Pattern Recognition · Computer Science 2025-09-10 Pooya Khosravi , Kun Han , Anthony T. Wu , Arghavan Rezvani , Zexin Feng , Xiaohui Xie