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The issue of combining individual $p$-values to aggregate multiple small effects is prevalent in many scientific investigations and is a long-standing statistical topic. Many classical methods are designed for combining independent and…

Methodology · Statistics 2021-09-08 Yusi Fang , George C. Tseng , Chung Chang

Missing data is a common issue in many biomedical studies. Under a paired design, some subjects may have missing values in either one or both of the conditions due to loss of follow-up, insufficient biological samples, etc. Such partially…

Cohort studies employ pairwise measures of association to quantify dependencies among conditions and exposures. To reliably use these measures to draw conclusions about the underlying association strengths requires that the measures be…

Quantitative Methods · Quantitative Biology 2017-05-30 Venkateshan Kannan , Kristina Alexandersson , Jesper Tegner

This paper develops new methodology, together with related theories, for combining information from independent studies through confidence distributions. A formal definition of a confidence distribution and its asymptotic counterpart (i.e.,…

Statistics Theory · Mathematics 2007-06-13 Kesar Singh , Minge Xie , William E. Strawderman

Meta-analysis is a statistical method used in evidence synthesis for combining, analyzing and summarizing studies that have the same target endpoint and aims to derive a pooled quantitative estimate using fixed and random effects models or…

Methodology · Statistics 2022-04-25 Ivette Raices Cruz , Matthias C. M. Troffaes , Johan Lindström , Ullrika Sahlin

Estimating the sharing of genetic effects across different conditions is important to many statistical analyses of genomic data. The patterns of sharing arising from these data are often highly heterogeneous. To flexibly model these…

Methodology · Statistics 2024-06-14 Yunqi Yang , Peter Carbonetto , David Gerard , Matthew Stephens

Estimates of uncertainty or variance in experimental means are central to physics. This is especially the case for `world averages' of fundamental physical parameters in particle physics, which aggregate results from a number of experiments…

High Energy Physics - Experiment · Physics 2023-10-13 Fintan Costello , Paul Watts

Designing an appropriate set of collective variables is crucial to the success of several enhanced sampling methods. Here we focus on how to obtain such variables from information limited to the metastable states. We characterize these…

Chemical Physics · Physics 2020-04-08 Luigi Bonati , Valerio Rizzi , Michele Parrinello

Nearest-neighbor methods have become popular in statistics and play a key role in statistical learning. Important decisions in nearest-neighbor methods concern the variables to use (when many potential candidates exist) and how to measure…

Methodology · Statistics 2024-01-31 Marcello D'Orazio

Meta-analysis aims to combine effect measures from several studies. For continuous outcomes, the most popular effect measures use simple or standardized differences in sample means. However, a number of applications focus on the absolute…

Methodology · Statistics 2023-10-03 Elena Kulinskaya , David C. Hoaglin

Naive Bayes(NB) is one of the essential algorithms in data mining. However, it is rarely used in reality because of the attribute independent assumption. Researchers have proposed many improved NB methods to alleviate this assumption. Among…

Machine Learning · Computer Science 2022-02-25 Xiaoliang Zhou , Dongyang Wu , Zitong You , Li Zhang , Ning Ye

Random-effects models are frequently used to synthesise information from different studies in meta-analysis. While likelihood-based inference is attractive both in terms of limiting properties and of implementation, its application in…

Methodology · Statistics 2018-02-16 Ioannis Kosmidis , Annamaria Guolo , Cristiano Varin

Collaboration between different data centers is often challenged by heterogeneity across sites. To account for the heterogeneity, the state-of-the-art method is to re-weight the covariate distributions in each site to match the distribution…

Machine Learning · Statistics 2024-04-25 Tianyu Guo , Sai Praneeth Karimireddy , Michael I. Jordan

Publication bias is a major concern in conducting systematic reviews and meta-analyses. Various sensitivity analysis or bias-correction methods have been developed based on selection models and they have some advantages over the widely used…

Methodology · Statistics 2021-09-28 Ao Huang , Kosuke Morikawa , Tim Friede , Satoshi Hattori

In adaptive data analysis, a mechanism gets $n$ i.i.d. samples from an unknown distribution $D$, and is required to provide accurate estimations to a sequence of adaptively chosen statistical queries with respect to $D$. Hardt and Ullman…

Machine Learning · Computer Science 2023-11-07 Kobbi Nissim , Uri Stemmer , Eliad Tsfadia

In the typical analysis of a data set, a single method is selected for statistical reporting even when equally applicable methods yield very different results. Examples of equally applicable methods can correspond to those of different…

Methodology · Statistics 2012-10-30 David R. Bickel

Comparative binary outcome data are of fundamental interest in statistics and are often pooled in meta-analyses. Here we examine the simplest case where for each study there are two patient groups and a binary event of interest, giving rise…

Methodology · Statistics 2018-06-12 Rose Baker , Dan Jackson

Publication bias, the fact that studies identified for inclusion in a meta analysis do not represent all studies on the topic of interest, is commonly recognized as a threat to the validity of the results of a meta analysis. One way to…

Methodology · Statistics 2023-04-17 Kaspar Rufibach

Genome-wide association analysis has generated much discussion about how to preserve power to detect signals despite the detrimental effect of multiple testing on power. We develop a weighted multiple testing procedure that facilitates the…

Statistics Theory · Mathematics 2007-06-13 Kathryn Roeder , Bernie Devlin , Larry Wasserman

From scientific experiments to online A/B testing, the previously observed data often affects how future experiments are performed, which in turn affects which data will be collected. Such adaptivity introduces complex correlations between…

Machine Learning · Statistics 2018-01-03 Xinkun Nie , Xiaoying Tian , Jonathan Taylor , James Zou