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Multimodal Machine Learning offers a holistic view of a patient's status, integrating structured and unstructured data from electronic health records (EHR). We propose a framework to predict metastasis risk one month prior to diagnosis,…

Machine Learning · Computer Science 2026-04-01 Franco Rugolon , Korbinian Randl , Braslav Jovanovic , Ioanna Miliou , Panagiotis Papapetrou

Accurate and robust cell nuclei classification is the cornerstone for a wider range of tasks in digital and Computational Pathology. However, most machine learning systems require extensive labeling from expert pathologists for each…

Quantitative Methods · Quantitative Biology 2016-12-05 Stefan Bauer , Nicolas Carion , Peter Schüffler , Thomas Fuchs , Peter Wild , Joachim M. Buhmann

Semantic segmentation constitutes an integral part of medical image analyses for which breakthroughs in the field of deep learning were of high relevance. The large number of trainable parameters of deep neural networks however renders them…

Computer Vision and Pattern Recognition · Computer Science 2017-02-28 Simon Kohl , David Bonekamp , Heinz-Peter Schlemmer , Kaneschka Yaqubi , Markus Hohenfellner , Boris Hadaschik , Jan-Philipp Radtke , Klaus Maier-Hein

One of the distinct characteristics in radiologists' reading of multiparametric prostate MR scans, using reporting systems such as PI-RADS v2.1, is to score individual types of MR modalities, T2-weighted, diffusion-weighted, and dynamic…

Image and Video Processing · Electrical Eng. & Systems 2024-01-23 Wen Yan , Bernard Chiu , Ziyi Shen , Qianye Yang , Tom Syer , Zhe Min , Shonit Punwani , Mark Emberton , David Atkinson , Dean C. Barratt , Yipeng Hu

Recent radiomic studies have witnessed promising performance of deep learning techniques in learning radiomic features and fusing multimodal imaging data. Most existing deep learning based radiomic studies build predictive models in a…

Computer Vision and Pattern Recognition · Computer Science 2019-01-08 Hongming Li , Pamela Boimel , James Janopaul-Naylor , Haoyu Zhong , Ying Xiao , Edgar Ben-Josef , Yong Fan

Current deep learning-based models typically analyze medical images in either 2D or 3D albeit disregarding volumetric information or suffering sub-optimal performance due to the anisotropic resolution of MR data. Furthermore, providing an…

Image and Video Processing · Electrical Eng. & Systems 2024-07-02 Alex Ling Yu Hung , Haoxin Zheng , Kai Zhao , Kaifeng Pang , Demetri Terzopoulos , Kyunghyun Sung

Prostate cancer is a commonly diagnosed cancerous disease among men world-wide. Even with modern technology such as multi-parametric magnetic resonance tomography and guided biopsies, the process for diagnosing prostate cancer remains time…

Image and Video Processing · Electrical Eng. & Systems 2024-04-17 Malte Rippa , Ruben Schulze , Marian Himstedt , Felice Burn

Cribriform growth patterns in prostate carcinoma are associated with poor prognosis. We aimed to introduce a deep learning method to detect such patterns automatically. To do so, convolutional neural network was trained to detect cribriform…

Image and Video Processing · Electrical Eng. & Systems 2020-09-14 Pierre Ambrosini , Eva Hollemans , Charlotte F. Kweldam , Geert J. L. H. van Leenders , Sjoerd Stallinga , Frans Vos

Molecular subtyping of breast cancer is crucial for personalized treatment and prognosis. Traditional classification approaches rely on either histopathological images or gene expression profiling, limiting their predictive power. In this…

Computer Vision and Pattern Recognition · Computer Science 2025-03-05 Amin Honarmandi Shandiz

There exists unexplained diverse variation within the predefined colon cancer stages using only features either from genomics or histopathological whole slide images as prognostic factors. Unraveling this variation will bring about improved…

Quantitative Methods · Quantitative Biology 2022-12-15 Olalekan Ogundipe , Zeyneb Kurt , Wai Lok Woo

Computer aided detection and diagnosis systems based on deep learning have shown promising performance in breast cancer detection. However, there are cases where the obtained results lack justification. In this study, our objective is to…

Computer Vision and Pattern Recognition · Computer Science 2023-06-01 Imane Nedjar , Mohammed Brahimi , Said Mahmoudi , Khadidja Abi Ayad , Mohammed Amine Chikh

Prostate cancer (PCa) is the second most common cancer diagnosed among men worldwide. The current PCa diagnostic pathway comes at the cost of substantial overdiagnosis, leading to unnecessary treatment and further testing. Bi-parametric…

Image and Video Processing · Electrical Eng. & Systems 2021-07-23 Alvaro Fernandez-Quilez , Trygve Eftestøl , Morten Goodwin , Svein Reidar Kjosavik , Ketil Oppedal

We present a pioneering investigation into the application of deep learning techniques to analyze histopathological images for addressing the substantial challenge of automated prognostic prediction. Prognostic prediction poses a unique…

Melanoma is a life-threatening form of skin cancer when left undiagnosed at the early stages. Although there are more cases of non-melanoma cancer than melanoma cancer, melanoma cancer is more deadly. Early detection of melanoma is crucial…

Image and Video Processing · Electrical Eng. & Systems 2020-05-15 Shreshth Saini , Divij Gupta , Anil Kumar Tiwari

Purpose: Medical foundation models (FMs) offer a path to build high-performance diagnostic systems. However, their application to prostate cancer (PCa) detection from micro-ultrasound ({\mu}US) remains untested in clinical settings. We…

Histology imaging is an essential diagnosis method to finalize the grade and stage of cancer of different tissues, especially for breast cancer diagnosis. Specialists often disagree on the final diagnosis on biopsy tissue due to the complex…

Computer Vision and Pattern Recognition · Computer Science 2019-09-17 Yongxiang Huang , Albert Chi-shing Chung

Recently, deep learning (DL) has automated and accelerated the clinical radiation therapy (RT) planning significantly by predicting accurate dose maps. However, most DL-based dose map prediction methods are data-driven and not applicable…

Image and Video Processing · Electrical Eng. & Systems 2023-08-22 Jie Zeng , Zeyu Han , Xingchen Peng , Jianghong Xiao , Peng Wang , Yan Wang

Multi-parametric MR images have been shown to be effective in the non-invasive diagnosis of prostate cancer. Automated segmentation of the prostate eliminates the need for manual annotation by a radiologist which is time consuming. This…

Computer Vision and Pattern Recognition · Computer Science 2020-12-29 Lavanya Umapathy , Wyatt Unger , Faryal Shareef , Hina Arif , Diego Martin , Maria Altbach , Ali Bilgin

Data scarcity hinders deep learning for medical imaging. We propose a framework for breast cancer classification in thermograms that addresses this using a Diffusion Probabilistic Model (DPM) for data augmentation. Our DPM-based…

Computer Vision and Pattern Recognition · Computer Science 2025-09-10 Sepehr Salem , M. Moein Esfahani , Jingyu Liu , Vince Calhoun

Prostate cancer, the second most prevalent male malignancy, requires advanced diagnostic tools. We propose an explainable AI system combining BERT (for textual clinical notes) and Random Forest (for numerical lab data) through a novel…

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