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Advances in robotic automation, high-performance computing (HPC), and artificial intelligence (AI) encourage us to conceive of science factories: large, general-purpose computation- and AI-enabled self-driving laboratories (SDLs) with the…

Quantum computing promises potential for science and industry by solving certain computationally complex problems faster than classical computers. Quantum computing systems evolved from monolithic systems towards modular architectures…

Quantum Physics · Physics 2023-08-15 Nishant Saurabh , Shantenu Jha , Andre Luckow

Recent advances in both theory and methods have created opportunities to simulate biomolecular processes more efficiently using adaptive ensemble simulations. Ensemble-based simulations are used widely to compute a number of individual…

Computational Engineering, Finance, and Science · Computer Science 2020-09-14 Vivek Balasubramanian , Travis Jensen , Matteo Turilli , Peter Kasson , Michael Shirts , Shantenu Jha

A key hurdle is demonstrating compute resource capability with limited benchmarks. We propose workflow templates as a solution, offering adaptable designs for specific scientific applications. Our paper identifies common usage patterns for…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-07-31 Gregor von Laszewski , Wesley Brewer , Sean R. Wilkinson , Andrew Shao , J. P. Fleischer , Harshad Pitkar , Christine R. Kirkpatrick , Geoffrey C. Fox

Job schedulers are a key component of scalable computing infrastructures. They orchestrate all of the work executed on the computing infrastructure and directly impact the effectiveness of the system. Recently, job workloads have…

Distributed, Parallel, and Cluster Computing · Computer Science 2018-03-06 Albert Reuther , Chansup Byun , William Arcand , David Bestor , Bill Bergeron , Matthew Hubbell , Michael Jones , Peter Michaleas , Andrew Prout , Antonio Rosa , Jeremy Kepner

Very High Resolution satellite and aerial imagery are used to monitor and conduct large scale surveys of ecological systems. Convolutional Neural Networks have successfully been employed to analyze such imagery to detect large animals and…

Distributed, Parallel, and Cluster Computing · Computer Science 2020-10-29 Aymen Al-Saadi , Ioannis Paraskevakos , Bento Collares Gonçalves , Heather J. Lynch , Shantenu Jha , Matteo Turilli

Cloud computing has emerged as a promising platform for running scientific workflows across various domains. Scientists can take advantage of different cloud service models, such as serverful or serverless, to execute workflows based on…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-04-29 Saeid Abrishami , Faridreza Momtaz Zandi , Alireza Nourbakhsh

Cloud-native is an approach to building and running scalable applications in modern cloud infrastructures, with the Kubernetes container orchestration platform being often considered as a fundamental cloud-native building block. In this…

Distributed, Parallel, and Cluster Computing · Computer Science 2024-08-29 Michal Orzechowski , Bartosz Balis , Krzysztof Janecki

The integration of Artificial Intelligence (AI) with High-Performance Computing (HPC) is transforming scientific workflows from human-directed pipelines into adaptive systems capable of autonomous decision-making. Large language models…

Quantum computers are moving into HPC centers, and the main challenge is now integration rather than pure hardware access. Many current software paths still depend on vendor-specific adapter chains between user SDKs, schedulers, and backend…

Artificial intelligence systems for scientific discovery have demonstrated remarkable potential, yet existing approaches remain largely proprietary and operate in batch-processing modes requiring hours per research cycle, precluding…

Artificial Intelligence · Computer Science 2026-01-28 Lukas Weidener , Marko Brkić , Mihailo Jovanović , Ritvik Singh , Chiara Baccin , Emre Ulgac , Alex Dobrin , Aakaash Meduri

High-performance computing (HPC) is reshaping computational drug discovery by enabling large-scale, time-efficient molecular simulations. In this work, we explore HPC-driven pipelines for Alzheimer's disease drug discovery, focusing on…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-09-03 Paul Ruiz Alliata , Diana Rubaga , Daniel Kumlin , Alberto Puliga

The application of psychophysiological in human-computer interaction is a growing field with significant potential for future smart personalised systems. Working in this emerging field requires comprehension of an array of physiological…

Human-Computer Interaction · Computer Science 2016-09-27 Jari Torniainen , Andreas Henelius

Efficient job scheduling and resource management contribute towards system throughput and efficiency maximization in high-performance computing (HPC) systems. In this paper, we introduce a scalable job scheduling and resource management…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-01-31 Abubeker Abdurahman , Abrar Hossain , Kevin A Brown , Kazutomo Yoshii , Kishwar Ahmed

Resource selection and task placement for distributed execution poses conceptual and implementation difficulties. Although resource selection and task placement are at the core of many tools and workflow systems, the methods are ad hoc…

Distributed, Parallel, and Cluster Computing · Computer Science 2021-11-04 Matteo Turilli , Yadu Nand Babuji , Andre Merzky , Ming Tai Ha , Michael Wilde , Daniel S. Katz , Shantenu Jha

In recent years, machine learning has transitioned from a field of academic research interest to a field capable of solving real-world business problems. However, the deployment of machine learning models in production systems can present a…

Machine Learning · Computer Science 2022-05-20 Andrei Paleyes , Raoul-Gabriel Urma , Neil D. Lawrence

High-Performance Computing (HPC) systems are the most powerful tools that we currently have to solve complex scientific simulations. Quantum computing (QC) has the potential to enhance HPC systems by accelerating the execution of specific…

Achieving a practical quantum advantage for near-term applications is widely expected to rely on hybrid classical-quantum algorithms. To deliver this practical advantage to users, high performance computing (HPC) centers need to provide a…

The recent successes and wide spread application of compute intensive machine learning and data analytics methods have been boosting the usage of the Python programming language on HPC systems. While Python provides many advantages for the…

Machine Learning · Computer Science 2020-12-02 Dominik Strassel , Philipp Reusch , Janis Keuper

The conventional model of resource allocation in HPC systems is static. Thus, a job cannot leverage newly available resources in the system or release underutilized resources during the execution. In this paper, we present Kub, a…

Distributed, Parallel, and Cluster Computing · Computer Science 2024-10-15 Daniel Medeiros , Jacob Wahlgren , Gabin Schieffer , Ivy Peng