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Most approaches to machine learning from electronic health data can only predict a single endpoint. Here, we present an alternative that uses unsupervised deep learning to simulate detailed patient trajectories. We use data comprising…
Epidemics of infectious diseases are an important threat to public health and global economies. Yet, the development of prevention strategies remains a challenging process, as epidemics are non-linear and complex processes. For this reason,…
This paper introduces an innovative framework designed for progressive (granular in time to onset) prediction of seizures through the utilization of a Deep Learning (DL) methodology based on non-invasive multi-modal sensor networks.…
Alzheimers Disease AD is an acute neuro disease that degenerates the brain cells and thus leads to memory loss progressively. It is a fatal brain disease that mostly affects the elderly. It steers the decline of cognitive and biological…
Accurate prediction of epileptic seizures could prove critical for improving patient safety and quality of life in drug-resistant epilepsy. Although deep learning-based approaches have shown promising seizure prediction performance using…
The increasing reliance on Computed Tomography Pulmonary Angiography (CTPA) for Pulmonary Embolism (PE) diagnosis presents challenges and a pressing need for improved diagnostic solutions. The primary objective of this study is to leverage…
Lung cancer, the second leading cause of cancer-related deaths, is primarily linked to long-term tobacco smoking (85% of cases). Surprisingly, 10-15% of cases occur in non-smokers. In 2020, approximately 2 million people were affected…
Childhood myopia constitutes a significant global health concern. It exhibits an escalating prevalence and has the potential to evolve into severe, irreversible conditions that detrimentally impact familial well-being and create substantial…
The neonatal period is the most vulnerable time for the development of seizures. Seizures in the immature brain lead to detrimental consequences, therefore require early diagnosis. The gold-standard for neonatal seizure detection currently…
Pneumonia has been one of the major causes of morbidities and mortality in the world and the prevalence of this disease is disproportionately high among the pediatric and elderly populations especially in resources trained areas Fast and…
Emergency Department overcrowding is a critical issue that compromises patient safety and operational efficiency, necessitating accurate demand forecasting for effective resource allocation. This study evaluates and compares three distinct…
High Flow Nasal Cannula (HFNC) provides non-invasive respiratory support for critically ill children who may tolerate it more readily than other Non-Invasive (NIV) techniques. Timely prediction of HFNC failure can provide an indication for…
We have performed cough detection based on measurements from an accelerometer attached to the patient's bed. This form of monitoring is less intrusive than body-attached accelerometer sensors, and sidesteps privacy concerns encountered when…
Objective: When patients develop acute respiratory failure, accurately identifying the underlying etiology is essential for determining the best treatment. However, differentiating between common medical diagnoses can be challenging in…
Digital screening and monitoring applications can aid providers in the management of behavioral health conditions. We explore deep language models for detecting depression, anxiety, and their co-occurrence from conversational speech…
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) affects 30-40% of US adults and is the most common chronic liver disease. Although often asymptomatic, progression can lead to cirrhosis. The objective of the…
Viewing the trajectory of a patient as a dynamical system, a recurrent neural network was developed to learn the course of patient encounters in the Pediatric Intensive Care Unit (PICU) of a major tertiary care center. Data extracted from…
Rare diseases affecting 350 million individuals are commonly associated with delay in diagnosis or misdiagnosis. To improve those patients' outcome, rare disease detection is an important task for identifying patients with rare conditions…
The objective of this study is to introduce methodology for studying longitudinal claims data observed at the patient level, with inference on the heterogeneity of healthcare utilization behaviors within large healthcare systems such as…
This thesis addresses the technical challenges of applying machine learning to understand and interpret medical audio signals. The sounds of our lungs, heart, and voice convey vital information about our health. Yet, in contemporary…