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A major challenge in single particle reconstruction methods using cryo-electron microscopy is to attain a resolution sufficient to interpret fine details in three-dimensional (3D) macromolecular structures. Obtaining high resolution 3D…

Numerical Analysis · Mathematics 2013-07-23 Lanhui Wang , Yoel Shkolnisky , Amit Singer

With the availability of more powerful computers, iterative reconstruction algorithms are the subject of an ongoing work in the design of more efficient reconstruction algorithms for X-ray computed tomography. In this work, we show how two…

Computer Vision and Pattern Recognition · Computer Science 2017-03-14 D. Trinca , Y. Zhong

Small animal PET scanners require high spatial resolution and good sensitivity. To reconstruct high-resolution images in 3D-PET, iterative methods, such as OSEM, are superior to analytical reconstruction algorithms, although their high…

Medical Physics · Physics 2007-05-23 J. L. Herraiz , S. Espana , J. J. Vaquero , M. Desco , J. M. Udias

Model-based learned iterative reconstruction methods have recently been shown to outperform classical reconstruction algorithms. Applicability of these methods to large scale inverse problems is however limited by the available memory for…

Image and Video Processing · Electrical Eng. & Systems 2020-04-21 Andreas Hauptmann , Jonas Adler , Simon Arridge , Ozan Öktem

X-ray tomographic reconstruction typically uses voxel basis functions to represent volumetric images. Due to the structure in voxel basis representations, efficient ray-tracing methods exist allowing fast, GPU accelerated implementations.…

Distributed, Parallel, and Cluster Computing · Computer Science 2019-08-20 Ander Biguri , Hossein Towsyfyan , Richard Boardman , Thomas Blumensath

Critical aspects of computational imaging systems, such as experimental design and image priors, can be optimized through deep networks formed by the unrolled iterations of classical model-based reconstructions (termed physics-based…

Computer Vision and Pattern Recognition · Computer Science 2020-03-13 Michael Kellman , Kevin Zhang , Jon Tamir , Emrah Bostan , Michael Lustig , Laura Waller

Reconstructing dynamic, time-varying scenes with computed tomography (4D-CT) is a challenging and ill-posed problem common to industrial and medical settings. Existing 4D-CT reconstructions are designed for sparse sampling schemes that…

Image and Video Processing · Electrical Eng. & Systems 2021-04-26 Albert W. Reed , Hyojin Kim , Rushil Anirudh , K. Aditya Mohan , Kyle Champley , Jingu Kang , Suren Jayasuriya

The inversion of linear systems is a fundamental step in many inverse problems. Computational challenges exist when trying to invert large linear systems, where limited computing resources mean that only part of the system can be kept in…

Distributed, Parallel, and Cluster Computing · Computer Science 2017-09-05 Yushan Gao , Thomas Blumensath

Compared to standard tomographic reconstruction, iterative approaches offer the possibility to account for extraneous experimental influences, which allows for a suppression of related artifacts. However, the inclusion of corresponding…

Image and Video Processing · Electrical Eng. & Systems 2022-02-18 Peter Modregger , Tomasz Korzec , Jeff Meganck , Lorenzo Massimi , Alessandro Olivo , Marco Endrizzi

X-ray computed tomography (CT) reveals the materials' internal structures non-destructively from a tilt series of projected images. Filtered back projection (FBP) is a widely-adopted reconstruction algorithm in CT owing to its small…

In dental cone-beam computed tomography (CBCT), compact and cost-effective system designs often use small detectors, resulting in a truncated field of view (FOV) that does not fully encompass the patient's head. In iterative reconstruction…

Computer Vision and Pattern Recognition · Computer Science 2025-08-12 Hyoung Suk Park , Kiwan Jeon

The performance of an iterative reconstruction algorithm for X-ray tomography is strongly determined by the features of the used forward and backprojector. For this reason, a large number of studies has focused on the to design of…

Computer Vision and Pattern Recognition · Computer Science 2016-12-19 Filippo Arcadu , Marco Stampanoni , Federica Marone

Phase-wrapping artifacts, statistical image noise and the need for a minimum amount of phase steps per projection limit the practicability of x-ray grating based phase-contrast tomography, when using filtered back projection reconstruction.…

Ultra low radiation dose in X-ray Computed Tomography (CT) is an important clinical objective in order to minimize the risk of carcinogenesis. Compressed Sensing (CS) enables significant reductions in radiation dose to be achieved by…

X-ray computed tomography is a commonly used technique for noninvasive imaging at synchrotron facilities. Iterative tomographic reconstruction algorithms are often preferred for recovering high quality 3D volumetric images from 2D X-ray…

Distributed, Parallel, and Cluster Computing · Computer Science 2020-09-16 Mert Hidayetoglu , Tekin Bicer , Simon Garcia de Gonzalo , Bin Ren , Vincent De Andrade , Doga Gursoy , Raj Kettimuthu , Ian T. Foster , Wen-mei W. Hwu

Convolutional neural networks (CNNs) have recently achieved remarkable performance in positron emission tomography (PET) image reconstruction. In particular, CNN-based direct PET image reconstruction, which directly generates the…

Medical Physics · Physics 2024-10-28 Fumio Hashimoto , Kibo Ote

While filtered back projection (FBP) is still the method of choice for fast tomographic reconstruction, its performance degrades noticeably in the presence of noise, incomplete sampling, or non-standard scan geometries. We propose a…

Numerical Analysis · Mathematics 2026-02-16 Hamid Fathi , Alexander Skorikov , Tristan van Leeuwen

For nonlinear multispectral computed tomography (CT), accurate and fast image reconstruction is challenging when the scanning geometries under different X-ray energy spectra are inconsistent or mismatched. Motivated by this, we propose an…

Numerical Analysis · Mathematics 2025-07-28 Yu Gao , Chong Chen

Spectral computed tomography (CT) is an emerging technology capable of providing high chemical specificity, which is crucial for many applications such as detecting threats in luggage. This type of application requires both fast and…

Image and Video Processing · Electrical Eng. & Systems 2021-03-30 Wail Mustafa , Christian Kehl , Ulrik Lund Olsen , Søren Kimmer Schou Gregersen , David Malmgren-Hansen , Jan Kehres , Anders Bjorholm Dahl

X-ray imaging dose from serial cone-beam CT (CBCT) scans raises a clinical concern in most image guided radiation therapy procedures. It is the goal of this paper to develop a fast GPU-based algorithm to reconstruct high quality CBCT images…

Medical Physics · Physics 2015-05-19 Xun Jia , Bin Dong , Yifei Lou , Steve B. Jiang