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In this paper, we address a distributed control problem for a system of partial differential equations describing the evolution of a tumor that takes the biological mechanism of chemotaxis into account. The system describing the evolution…

Optimization and Control · Mathematics 2023-09-19 Gianni Gilardi , Andrea Signori , Jürgen Sprekels

We investigate a distributed optimal control problem for a phase field model of Cahn-Hilliard type. The model describes two-species phase segregation on an atomic lattice under the presence of diffusion; it has been recently introduced by…

Analysis of PDEs · Mathematics 2015-05-28 Pierluigi Colli , Gianni Gilardi , Paolo Podio-Guidugli , Jürgen Sprekels

A distributed optimal control problem for an extended model of phase field type for tumor growth is addressed. In this model, the chemotaxis effects are also taken into account. The control is realized by two control variables that design…

Analysis of PDEs · Mathematics 2021-03-23 Pierluigi Colli , Andrea Signori , Jürgen Sprekels

This paper treats a distributed optimal control problem for a tumor growth model of viscous Cahn--Hilliard type. The evolution of the tumor fraction is governed by a thermodynamic force induced by a double-well potential of logarithmic…

Optimization and Control · Mathematics 2023-06-14 Jürgen Sprekels , Fredi Tröltzsch

We study a distributed optimal control problem for a nonisothermal Caginalp-type phase-field model that describes tumour growth under thermal therapy. The PDE system couples a possibly viscous Cahn-Hilliard equation, governing the evolution…

Optimization and Control · Mathematics 2026-05-05 Giulia Cavalleri , Pierluigi Colli , Elisabetta Rocca

We investigate a distributed optimal control problem for a nonlocal phase field model of viscous Cahn-Hilliard type. The model constitutes a nonlocal version of a model for two-species phase segregation on an atomic lattice under the…

Analysis of PDEs · Mathematics 2016-09-19 Pierluigi Colli , Gianni Gilardi , Jürgen Sprekels

In this paper, we study an optimal control problem for a macroscopic mechanical tumour model based on the phase field approach. The model couples a Cahn--Hilliard type equation to a system of linear elasticity and a reaction-diffusion…

Optimization and Control · Mathematics 2021-04-21 Harald Garcke , Kei Fong Lam , Andrea Signori

In this work, we investigate a distributed optimal control problem for an extended phase field system of Cahn--Hilliard type which physical context is that of tumor growth dynamics. In a previous contribution, the author has already studied…

Analysis of PDEs · Mathematics 2019-08-30 Andrea Signori

In this paper, we study an optimal control problem for a nonlinear system of reaction-diffusion equations that constitutes a simplified and relaxed version of a thermodynamically consistent phase field model for tumor growth originally…

Optimization and Control · Mathematics 2020-08-25 Jürgen Sprekels , Fredi Tröltzsch

In their recent work `Well-posedness, regularity and asymptotic analyses for a fractional phase field system' (Asymptot. Anal. 114 (2019), 93-128; see also the preprint arXiv:1806.04625), two of the present authors have studied phase field…

Analysis of PDEs · Mathematics 2020-05-28 Pierluigi Colli , Gianni Gilardi , Jürgen Sprekels

In this paper, we study the optimal control of a phase field model for a tumor growth model of Cahn--Hilliard type in which the often assumed parabolic relaxation of the chemical potential is replaced by a hyperbolic one. Both the cases…

Optimization and Control · Mathematics 2026-03-17 Pierluigi Colli , Elisabetta Rocca , Jürgen Sprekels

We consider a diffuse interface model for tumor growth consisting of a Cahn--Hilliard equation with source terms coupled to a reaction-diffusion equation, which models a tumor growing in the presence of a nutrient species and surrounded by…

Analysis of PDEs · Mathematics 2017-05-04 Harald Garcke , Kei Fong Lam

In this paper we study a distributed control problem for a phase-field system of conserved type with a possibly singular potential. We mainly handle two cases: the case of a viscous Cahn-Hilliard type dynamics for the phase variable in case…

Analysis of PDEs · Mathematics 2017-09-12 P. Colli , G. Gilardi , G. Marinoschi , E. Rocca

This paper is concerned with a distributed optimal control problem for a nonlocal phase field model of Cahn-Hilliard type, which is a nonlocal version of a model for two-species phase segregation on an atomic lattice under the presence of…

Analysis of PDEs · Mathematics 2016-07-08 Pierluigi Colli , Gianni Gilardi , Jürgen Sprekels

We consider an optimal control problem that entails the minimization of a nondifferentiable cost functional, fractional diffusion as state equation and constraints on the control variable. We provide existence, uniqueness and regularity…

Numerical Analysis · Mathematics 2017-04-05 Enrique Otárola , Abner J. Salgado

The paper arXiv:1804.11290 contains well-posedness and regularity results for a system of evolutionary operator equations having the structure of a Cahn-Hilliard system. The operators appearing in the system equations were fractional…

Analysis of PDEs · Mathematics 2018-12-17 Pierluigi Colli , Gianni Gilardi , Jürgen Sprekels

This paper deals with a general system of equations and conditions arising from a mathematical model of prostate cancer growth with chemotherapy and antiangiogenic therapy that has been recently introduced and analyzed (see [P. Colli et…

Analysis of PDEs · Mathematics 2021-04-02 Pierluigi Colli , Gianni Gilardi , Jürgen Sprekels

The paper treats the problem of optimal distributed control of a Cahn-Hilliard-Oono system in $\mathbb{R}^d$, $1\leq d\leq 3$, with the control located in the mass term and admitting general potentials that include both the case of a…

Analysis of PDEs · Mathematics 2022-06-02 Pierluigi Colli , Gianni Gilardi , Elisabetta Rocca , Jürgen Sprekels

In this paper we study nonlocal-to-local asymptotics for a tumor-growth model coupling a viscous Cahn-Hilliard equation describing the tumor proportion with a reaction-diffusion equation for the nutrient phase parameter. First, we prove…

Analysis of PDEs · Mathematics 2023-11-20 Elisa Davoli , Elisabetta Rocca , Luca Scarpa , Lara Trussardi

We analyze a phase field model for tumor growth consisting of a Cahn-Hilliard-Brinkman system, ruling the evolution of the tumor mass, coupled with an advection-reaction-diffusion equation for a chemical species acting as a nutrient. The…

Analysis of PDEs · Mathematics 2023-07-26 Pierluigi Colli , Gianni Gilardi , Andrea Signori , Jürgen Sprekels