Related papers: The interplay between tissue healing and bone remo…
We study a cross-diffusion model for tissue regeneration which involves the dynamics of human mesenchymal stem cells interacting with chondrocytes in a medium containing a differentiation factor. The latter acts as a chemoattractant for the…
Bioelastomers have demonstrated tremendous value and potential in the field of tissue repair due to increasing health demands. Improved non-invasive methods are required for monitoring tissue development assisted by bioelastomers. In this…
After more than five decades of research, the failure of bone implants is still an issue that becomes increasingly urgent to solve in our ageing population. Among the reasons for failure, catastrophic brittle fracture is one event that is…
We propose a simple model for scaffold aided bone regeneration. In this model, only macroscopic quantities, e.g., locally averaged osteoblast densities, are considered. This allows for use of this model in an optimization algorithm, whose…
The mechanics of biological tissues mainly proceeds from the cell cortex rheology. A direct, explicit link between cortex rheology and tissue rheology remains lacking, yet would be instrumental in understanding how modulations of cortical…
This paper presents simulations of the impact of tongue surgery on tongue movements and on speech articulation. For this, a 3D biomechanical Finite Element (FE) model of the tongue is used. Muscles are represented within the FE structure by…
During development, epithelial tissues undergo extensive morphogenesis based on coordinated changes of cell shape and position over time. Continuum mechanics describes tissue mechanical state and shape changes in terms of strain and stress.…
Deployable structures, essential across various engineering applications ranging from umbrellas to satellites, are evolving to include soft, morphable designs where geometry drives transformation. However, a major challenge for soft…
Embryonic tissues deform across broad spatial and temporal scales and relax stress through active rearrangements. A quantitative link between cell-scale activity, spatial forcing, and emergent tissue-scale mechanics remains incomplete.…
A quantitative understanding of how cells interact with their extracellular matrix via molecular bonds is fundamental for many important processes in cell biology and engineering. In these interactions, the deformability of cells and matrix…
Structural cellular materials in nature, such as wood, trabecular bone, corals, and dentin combine complex biological functions with structural roles, such as skeletal support and impact protection1,2. They feature complex structural…
Over the last two decades, scientific literature has been blooming with various means of simulating epithelial cell colonies. Each of these simulations can be separated by their respective efficiency (expressed in terms of consumed…
Some implants have approximately a lifetime of 15 years. The femoral stem, for example, should be made of 316L/316LN stainless steel. Fretting corrosion, friction under small displacements, should occur during human gait, due to repeated…
In this study, we present the first simulation results of the formation of dislocation cell wall microstructures in tantalum subjected to shock loading. Dislocation patterns and cell wall formation are important to understanding the…
We explore the conductance of self-healing materials as a measure of the material integrity in the regime of the onset of the initial fatigue. Continuum effective-field modeling and lattice numerical simulations are reported. Our results…
As small particles skim our airways during breathing, or our intestines during digestion, the surface epithelium is subjected to local exogenous shear that deforms hundreds to thousands of tightly interacting cells. Unlike shear…
The process of wound healing has been an active area of research around the world. The problem is the wounds of different patients heal differently. For example, patients with a background of diabetes may have difficulties in healing [1].…
The polarisation of cells and tissues is fundamental for tissue morphogenesis during biological development and regeneration. A deeper understanding of biological polarity pattern formation can be gained from the consideration of pattern…
There is experimental and histological evidence that chronic irritation and cell death may cause hyperplasia in the exposed tissue. As the heterogeneous deposition of inhaled radon progeny results in high local doses at the peak of the…
Geochemical data provide key information on the timing of accretion and on the prevailing physical conditions during core/mantle differentiation. However, their interpretation depends critically on the efficiency of metal/silicate chemical…