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Quantification of myocardial perfusion has the potential to improve detection of regional and global flow reduction. Significant effort has been made to automate the workflow, where one essential step is the arterial input function (AIF)…

Quantitative Methods · Quantitative Biology 2020-05-11 Hui Xue , Ethan Tseng , Kristopher D Knott , Tushar Kotecha , Louise Brown , Sven Plein , Marianna Fontana , James C Moon , Peter Kellman

Objectives: Atrial fibrillation (AF) is a common heart rhythm disorder associated with deadly and debilitating consequences including heart failure, stroke, poor mental health, reduced quality of life and death. Having an automatic system…

Signal Processing · Electrical Eng. & Systems 2018-01-31 Philip Warrick , Masun Nabhan Homsi

Unplanned failures in industrial hydraulic pumps can halt production and incur substantial costs. We explore two unsupervised autoencoder (AE) schemes for early fault detection: a feed-forward model that analyses individual sensor snapshots…

Machine Learning · Computer Science 2026-01-19 P. Sánchez , K. Reyes , B. Radu , E. Fernández

Accurate estimates of left ventricle elastances based on non-invasive measurements are required for clinical decision-making during treatment of valvular diseases. The present study proposes a parameter discovery approach based on a lumped…

Medical Physics · Physics 2022-05-26 Ryno Laubscher , Johan Van Der Merwe , Jacques Liebenberg , Philip Herbst

Progression to dialysis or end-stage renal disease is a rare but clinically important outcome. Clinicians need evidence on how medication exposures influence downstream risk. We constructed a fixed-window EHR cohort (90-day observation,…

Machine Learning · Computer Science 2026-04-28 Kalyani P. Pande , Evan Yang , Bryan Zhu , Sandeep K. Mallipattu , Alisa Yurovsky , Tengfei Ma

Understanding the causes and patient impacts of surgical adverse events will help improve systems and operational practices to avoid incidents in the future. We analyzed the adverse events data related to robotic systems and instruments…

Robotics · Computer Science 2016-11-29 Homa Alemzadeh , Ravishankar K. Iyer , Zbigniew Kalbarczyk , Nancy Leveson , Jaishankar Raman

Understanding intraventricular hemodynamics requires compact and physically interpretable representations of the underlying flow structures, as characteristic flow patterns are closely associated with cardiovascular conditions and can…

Cardiovascular diseases, a leading cause of noncommunicable disease-related deaths, require early and accurate detection to improve patient outcomes. Taking advantage of advances in machine learning and deep learning, multiple approaches…

Computer Vision and Pattern Recognition · Computer Science 2025-02-12 Paula Ruiz-Barroso , Francisco M. Castro , José Miranda , Denisa-Andreea Constantinescu , David Atienza , Nicolás Guil

Background Atrial fibrillation is often missed by traditional intermittent electrocardiogram monitoring after ischemic stroke due to its paroxysmal and asymptomatic nature. The knowledge of the unique characteristics of the population with…

Neurons and Cognition · Quantitative Biology 2023-05-25 Yiming Chen , Sihui Wang , Dong Xu

Longitudinal datasets measured repeatedly over time from individual subjects, arise in many biomedical, psychological, social, and other studies. A common approach to analyse high-dimensional data that contains missing values is to learn a…

Machine Learning · Statistics 2021-04-21 Siddharth Ramchandran , Gleb Tikhonov , Kalle Kujanpää , Miika Koskinen , Harri Lähdesmäki

Background. Alzheimer's disease and related dementia (ADRD) are characterized by multiple and progressive anatomo clinical changes. Yet, modeling changes over disease course from cohort data is challenging as the usual timescales are…

A significant percentage of COVID-19 survivors experience ongoing multisystemic symptoms that often affect daily living, a condition known as Long Covid or post-acute-sequelae of SARS-CoV-2 infection. However, identifying scientific…

Machine Learning · Computer Science 2022-10-31 Robert Leaman , Rezarta Islamaj , Alexis Allot , Qingyu Chen , W. John Wilbur , Zhiyong Lu

Objective: To develop prognostic survival models for predicting adverse outcomes after catheter ablation treatment for non-valvular atrial fibrillation (AF). Methods: We used a linked dataset including hospital administrative data,…

Machine Learning · Computer Science 2024-02-19 Juan C. Quiroz , David Brieger , Louisa Jorm , Raymond W Sy , Benjumin Hsu , Blanca Gallego

This study creates a physiologically realistic virtual patient database (VPD), representing the human arterial system, for the primary purpose of studying the affects of arterial disease on haemodynamics. A low dimensional representation of…

Medical Physics · Physics 2021-08-05 Gareth Jones , Jim Parr , Perumal Nithiarasu , Sanjay Pant

This study presents a novel methodology for stratifying post-myocardial infarction patients at risk of ventricular arrhythmias using patient-specific 3D cardiac models derived from late gadolinium enhancement cardiovascular magnetic…

Computational Engineering, Finance, and Science · Computer Science 2024-09-11 Dolors Serra , Pau Romero , Paula Franco , Ignacio Bernat , Miguel Lozano , Ignacio Garcia-Fernandez , David Soto , Antonio Berruezo , Oscar Camara , Rafael Sebastian

Period-prevalent cohorts are often used for their cost-saving potential in epidemiological studies of survival outcomes. Under this design, prevalent patients allow for evaluations of long-term survival outcomes without the need for long…

Methodology · Statistics 2024-10-28 Nicholas Hartman

Real-World Data (RWD), with its large sample sizes and rich clinical detail, offers a compelling alternative to randomized controlled trials (RCTs) for studying treatment effects in diverse and complex patient populations. However, its…

Applications · Statistics 2026-05-26 Yifei Xu , Hwiyoung Lee , Zhenyao Ye , Yezhi Pan , Jingsong Zhou , Yun Yang , Chixiang Chen , Shuo Chen

Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia worldwide, with 2% of the population affected. It is associated with an increased risk of strokes, heart failure and other heart-related complications. Monitoring at-risk…

Machine Learning · Computer Science 2021-11-24 Sideshwar J B , Sachin Krishan T , Vishal Nagarajan , Shanthakumar S , Vineeth Vijayaraghavan

Patients with chronic obstructive pulmonary disease (COPD) have an increased risk of hospitalizations, strongly associated with decreased survival, yet predicting the timing of these events remains challenging and has received limited…

Electronic Health Records (EHRs) are typically stored as time-stamped encounter records. Observing temporal relationship between medical records is an integral part of interpreting the information. Hence, statistical analysis of EHRs…

Applications · Statistics 2020-07-29 Anne Woods , Craig Meyer , Brian Sauer , Beth Cohen