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This paper addresses patient heterogeneity associated with prediction problems in biomedical applications. We propose a systematic hypothesis testing approach to determine the existence of patient subgroup structure and the number of…

Methodology · Statistics 2021-01-08 Xu Gao , Weining Shen , Jing Ning , Ziding Feng , Jianhua Hu

Clinical trials are central to medical progress because they help improve understanding of human health and the healthcare system. They play a key role in discovering new ways to detect, prevent, or treat diseases, and it is essential that…

Computation and Language · Computer Science 2025-10-16 Surya Tejaswi Yerramsetty , Almas Fathimah

Objective: We investigate whether deep learning techniques for natural language processing (NLP) can be used efficiently for patient phenotyping. Patient phenotyping is a classification task for determining whether a patient has a medical…

Collaborative competitions have gained popularity in the scientific and technological fields. These competitions involve defining tasks, selecting evaluation scores, and devising result verification methods. In the standard scenario,…

Machine Learning · Computer Science 2024-08-22 Sergio Nava-Muñoz , Mario Graff , Hugo Jair Escalante

This paper describes our submission to Task 2 of SemEval-2024: Safe Biomedical Natural Language Inference for Clinical Trials. The Multi-evidence Natural Language Inference for Clinical Trial Data (NLI4CT) consists of a Textual Entailment…

Computation and Language · Computer Science 2024-04-08 Mathilde Aguiar , Pierre Zweigenbaum , Nona Naderi

Clinical language processing has received a lot of attention in recent years, resulting in new models or methods for disease phenotyping, mortality prediction, and other tasks. Unfortunately, many of these approaches are tested under…

Computation and Language · Computer Science 2022-09-30 Travis R. Goodwin , Dina Demner-Fushman

Many classification problems require decisions among a large number of competing classes. These tasks, however, are not handled well by general purpose learning methods and are usually addressed in an ad-hoc fashion. We suggest a general…

Artificial Intelligence · Computer Science 2007-05-23 Yair Even-Zohar , Dan Roth

This technical report introduces a Named Clinical Entity Recognition Benchmark for evaluating language models in healthcare, addressing the crucial natural language processing (NLP) task of extracting structured information from clinical…

For natural language understanding (NLU) technology to be maximally useful, both practically and as a scientific object of study, it must be general: it must be able to process language in a way that is not exclusively tailored to any one…

Computation and Language · Computer Science 2019-02-26 Alex Wang , Amanpreet Singh , Julian Michael , Felix Hill , Omer Levy , Samuel R. Bowman

Clinical studies often require understanding elements of a patient's narrative that exist only in free text clinical notes. To transform notes into structured data for downstream use, these elements are commonly extracted and normalized to…

Computation and Language · Computer Science 2020-08-03 Monica Agrawal , Chloe O'Connell , Yasmin Fatemi , Ariel Levy , David Sontag

Background: Patient recruitment in clinical trials is hindered by complex eligibility criteria and labor-intensive chart reviews. Prior research using text-only models have struggled to address this problem in a reliable and scalable way…

Computation and Language · Computer Science 2025-03-20 Anatole Callies , Quentin Bodinier , Philippe Ravaud , Kourosh Davarpanah

Clinical trials are crucial for assessing new treatments; however, recruitment challenges - such as limited awareness, complex eligibility criteria, and referral barriers - hinder their success. With the growth of online platforms, patients…

Information Retrieval · Computer Science 2025-04-30 Joey Chan , Qiao Jin , Nicholas Wan , Charalampos S. Floudas , Elisabetta Xue , Zhiyong Lu

Randomized controlled trials (RCTs) represent the paramount evidence of clinical medicine. Using machines to interpret the massive amount of RCTs has the potential of aiding clinical decision-making. We propose a RCT conclusion generation…

Computation and Language · Computer Science 2019-10-04 Alexander Te-Wei Shieh , Yung-Sung Chuang , Shang-Yu Su , Yun-Nung Chen

Screening patients for clinical trial eligibility remains a manual, time-consuming, and resource-intensive process. We present a secure, scalable proof-of-concept system for Artificial Intelligence (AI)-augmented patient-trial matching that…

This paper describes the submissions of the Natural Language Processing (NLP) team from the Australian Research Council Industrial Transformation Training Centre (ITTC) for Cognitive Computing in Medical Technologies to the TREC 2021…

A probabilistic expert system emulates the decision-making ability of a human expert through a directional graphical model. The first step in building such systems is to understand data generation mechanism. To this end, one may try to…

Methodology · Statistics 2021-09-29 Vahid Partovi Nia , Xinlin Li , Masoud Asgharian , Shoubo Hu , Zhitang Chen , Yanhui Geng

While a wide range of different, sometimes heterogeneous test coverage criteria have been proposed, there exists no generic formalism to describe them, and available test automation tools usually support only a small subset of them. We…

Software Engineering · Computer Science 2017-01-20 Sébastien Bardin , Mickaël Delahaye , Nikolai Kosmatov , Michaël Marcozzi , Virgile Prevosto

In the problem of classical group testing one aims to identify a small subset (of size $d$) diseased individuals/defective items in a large population (of size $n$). This process is based on a minimal number of suitably-designed group tests…

Information Theory · Computer Science 2022-09-26 Xiwei Cheng , Sidharth Jaggi , Qiaoqiao Zhou

A tagger is a mandatory segment of most text scrutiny systems, as it consigned a s yntax class (e.g., noun, verb, adjective, and adverb) to every word in a sentence. In this paper, we present a simple part of speech tagger for homoeopathy…

Computation and Language · Computer Science 2011-11-23 Sanjay K. Dwivedi , Pramod P. Sukhadeve

Matching patients to clinical trial options is critical for identifying novel treatments, especially in oncology. However, manual matching is labor-intensive and error-prone, leading to recruitment delays. Pipelines incorporating large…

Computation and Language · Computer Science 2025-09-25 Braxton A. Morrison , Madhumita Sushil , Jacob S. Young