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In randomized trials, once the total effect of the intervention has been estimated, it is often of interest to explore mechanistic effects through mediators along the causal pathway between the randomized treatment and the outcome. In the…

Methodology · Statistics 2021-12-28 Erin E Gabriel , Michael C Sachs , Arvid Sjölander

Robins and Richardson (2010) reformulated mediation analysis by decomposing treatments into multiple components and examining separable effects of each component. While this approach is increasingly popular, existing work has analyzed…

Methodology · Statistics 2026-05-08 Chan Park , Youmi Suk

Mediation analysis draws increasing attention in many scientific areas such as genomics, epidemiology and finance. In this paper, we propose new statistical inference procedures for high dimensional mediation models, in which both the…

Methodology · Statistics 2021-08-30 Xu Guo , Runze Li , Jingyuan Liu , Mudong Zeng

The recently published ICH E9 addendum on estimands in clinical trials provides a framework for precisely defining the treatment effect that is to be estimated, but says little about estimation methods. Here we report analyses of a clinical…

Applications · Statistics 2023-09-25 Camila Olarte Parra , Rhian M. Daniel , David Wright , Jonathan W. Bartlett

Estimation of social influence in networks can be substantially biased in observational studies due to homophily and network correlation in exposure to exogenous events. Randomized experiments, in which the researcher intervenes in the…

Social and Information Networks · Computer Science 2017-09-28 Sean J. Taylor , Dean Eckles

Accurate estimation of treatment effects is essential for decision-making across various scientific fields. This task, however, becomes challenging in areas like social sciences and online marketplaces, where treating one experimental unit…

Machine Learning · Computer Science 2025-02-04 Mohsen Bayati , Yuwei Luo , William Overman , Sadegh Shirani , Ruoxuan Xiong

The use of data-driven decision support by public agencies is becoming more widespread and already influences the allocation of public resources. This raises ethical concerns, as it has adversely affected minorities and historically…

Machine Learning · Computer Science 2023-02-03 Sebastian Scher , Simone Kopeinik , Andreas Trügler , Dominik Kowald

E-commerce companies have a number of online products, such as organic search, sponsored search, and recommendation modules, to fulfill customer needs. Although each of these products provides a unique opportunity for users to interact with…

Applications · Statistics 2020-06-23 Xuan Yin , Liangjie Hong

Randomized clinical trials are considered the gold standard for informing treatment guidelines, but results may not generalize to real-world populations. Generalizability is hindered by distributional differences in baseline covariates and…

Methodology · Statistics 2025-06-03 Rachael K. Ross , Ivan Diaz , Amy J. Pitts , Elizabeth A. Stuart , Kara E. Rudolph

In mobile health interventions aimed at behavior change and maintenance, treatments are provided in real time to manage current or impending high risk situations or promote healthy behaviors in near real time. Currently there is great…

Methodology · Statistics 2016-08-18 Audrey Boruvka , Daniel Almirall , Katie Witkiewitz , Susan A. Murphy

Proximal causal inference was recently proposed as a framework to identify causal effects from observational data in the presence of hidden confounders for which proxies are available. In this paper, we extend the proximal causal inference…

Statistics Theory · Mathematics 2023-01-27 AmirEmad Ghassami , Alan Yang , Ilya Shpitser , Eric Tchetgen Tchetgen

Social networks contain data on both actor attributes and social connections among them. Such connections reflect the dependence among social actors, which is important for individual's mental health and social development. To investigate…

Methodology · Statistics 2025-01-08 Haiyan Liu , Ick Hoon Jin , Zhiyong Zhang , Ying Yuan

Environmental health studies are increasingly measuring endogenous omics data ($\boldsymbol{M}$) to study intermediary biological pathways by which an exogenous exposure ($\boldsymbol{A}$) affects a health outcome ($\boldsymbol{Y}$), given…

The decomposition of the overall effect of a treatment into direct and indirect effects is here investigated with reference to a recursive system of binary random variables. We show how, for the single mediator context, the marginal effect…

Methodology · Statistics 2025-11-14 Martina Raggi , Elena Stanghellini , Marco Doretti

There are limited options to estimate the treatment effects of variables which are continuous and measured at multiple time points, particularly if the true dose-response curve should be estimated as closely as possible. However, these…

Methodology · Statistics 2024-10-11 Michael Schomaker , Helen McIlleron , Paolo Denti , Iván Díaz

Mediation analysis learns the causal effect transmitted via mediator variables between treatments and outcomes and receives increasing attention in various scientific domains to elucidate causal relations. Most existing works focus on…

Machine Learning · Statistics 2023-09-06 Lin Ge , Jitao Wang , Chengchun Shi , Zhenke Wu , Rui Song

Eating disorders are complex mental health conditions that affect millions of people around the world. Effective interventions on social media platforms are crucial, yet testing strategies in situ can be risky. We present a novel LLM-driven…

Computation and Language · Computer Science 2024-09-09 Louis Penafiel , Hsien-Te Kao , Isabel Erickson , David Chu , Robert McCormack , Kristina Lerman , Svitlana Volkova

In situations with non-manipulable exposures, interventions can be targeted to shift the distribution of intermediate variables between exposure groups to define interventional disparity indirect effects. In this work, we present a…

Methodology · Statistics 2023-05-18 Helene C. W. Rytgaard , Amalie Lykkemark Møller , Thomas A. Gerds

In causal inference, it is common to estimate the causal effect of a single treatment variable on an outcome. However, practitioners may also be interested in the effect of simultaneous interventions on multiple covariates of a fixed target…

Methodology · Statistics 2022-11-24 Jaime Roquero Gimenez , Dominik Rothenhäusler

Mediation analysis has become a widely used method for identifying the pathways through which an independent variable influences a dependent variable via intermediate mediators. However, limited research addresses the case where mediators…

Methodology · Statistics 2025-06-10 Rui Ren , Haoyi Yang , Qian Xiao , Lingzhou Xue , Yuan Huang