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Radiotherapy (RT) is a key component in the treatment of various cancers, including Acute Lymphocytic Leukemia (ALL) and Acute Myelogenous Leukemia (AML). Precise delineation of organs at risk (OARs) and target areas is essential for…

Computer Vision and Pattern Recognition · Computer Science 2023-11-14 Ricardo Coimbra Brioso , Damiano Dei , Ciro Franzese , Nicola Lambri , Daniele Loiacono , Pietro Mancosu , Marta Scorsetti

The computational analysis of Mass Spectrometry Imaging (MSI) data aims at the identification of interesting mass co-localizations and the visualization of their lateral distribution in the sample, usually a tissue cross section. But as the…

Computer Vision and Pattern Recognition · Computer Science 2020-10-01 Karsten Wüllems , Tim W. Nattkemper

In the management of lung nodules, we are desirable to predict nodule evolution in terms of its diameter variation on Computed Tomography (CT) scans and then provide a follow-up recommendation according to the predicted result of the…

Image and Video Processing · Electrical Eng. & Systems 2022-06-08 Jiansheng Fang , Jingwen Wang , Anwei Li , Yuguang Yan , Yonghe Hou , Chao Song , Hongbo Liu , Jiang Liu

Rapid technological advances in radiation therapy have significantly improved dose delivery and tumor control for head and neck cancers. However, treatment-related toxicities caused by high-dose exposure to critical structures remain a…

Tumor treating fields (TTFields) is an FDA approved therapy for the treatment of Gliobastoma Multiform (GBM) and currently being investigated for additional tumor types. TTFields are delivered to the tumor through the placement of…

Image and Video Processing · Electrical Eng. & Systems 2019-06-27 Reuben R Shamir , Zeev Bomzon

The tumor microenvironment (TME) significantly impacts cancer prognosis due to its immune composition. While therapies for altering the immune composition, including immunotherapies, have shown exciting results for treating hematological…

Quantitative Methods · Quantitative Biology 2023-10-17 Zitong Jerry Wang , Alexander M. Xu , Aman Bhargava , Matt W. Thomson

Head and neck tumors and metastatic lymph nodes are crucial for treatment planning and prognostic analysis. Accurate segmentation and quantitative analysis of these structures require pixel-level annotation, making automated segmentation…

Image and Video Processing · Electrical Eng. & Systems 2025-04-01 Litingyu Wang , Wenjun Liao , Shichuan Zhang , Guotai Wang

The rapid development in information technology has immensely contributed to the use of modern approaches for visualizing volumetric data. Consequently, medical volume visualization is increasingly attracting attention towards achieving an…

Computational Geometry · Computer Science 2012-11-27 A. M. Adeshina , R. Hashim , N. E. A. Khalid , Siti Z. Z. Abidin

Locoregional recurrences (LRR) are still a frequent site of treatment failure for head and neck squamous cell carcinoma (HNSCC) patients. Identification of high risk subvolumes based on pretreatment imaging is key to biologically targeted…

Cancer remains a leading cause of death, highlighting the importance of effective radiotherapy (RT). Magnetic resonance-guided linear accelerators (MR-Linacs) enable imaging during RT, allowing for inter-fraction, and perhaps even…

Quantitative extraction of high-dimensional mineable data from medical images is a process known as radiomics. Radiomics is foreseen as an essential prognostic tool for cancer risk assessment and the quantification of intratumoural…

Tumor-stroma ratio (TSR) is a prognostic factor for many types of solid tumors. In this study, we propose a method for automated estimation of TSR from histopathological images of colorectal cancer. The method is based on convolutional…

Computer Vision and Pattern Recognition · Computer Science 2023-06-07 Liisa Petäinen , Juha P. Väyrynen , Pekka Ruusuvuori , Ilkka Pölönen , Sami Äyrämö , Teijo Kuopio

Background: Multiparametric breast MRI data might improve tumor diagnostics, characterization, and treatment planning. Accurate alignment and delineation of images acquired at different field strengths such as 3T and 7T, remain challenging…

Image and Video Processing · Electrical Eng. & Systems 2025-01-24 Muhammad Shahkar Khan , Haider Ali , Laura Villazan Garcia , Noor Badshah , Siegfried Trattnig , Florian Schwarzhans , Ramona Woitek , Olgica Zaric

Purpose: Organ-at-risk (OAR) delineation is a key step for cone-beam CT (CBCT) based adaptive radiotherapy planning that can be a time-consuming, labor-intensive, and subject-to-variability process. We aim to develop a fully automated…

Purpose: To verify dose delivery and quality assurance of volumetric modulated arc therapy (VMAT) for head and neck cancer. Method: The Imaging and Radiation Oncology Core Houston (IROC-H) head and neck phantom with thermo- luminescent…

We present Region Similarity Representation Learning (ReSim), a new approach to self-supervised representation learning for localization-based tasks such as object detection and segmentation. While existing work has largely focused on…

Computer Vision and Pattern Recognition · Computer Science 2021-08-20 Tete Xiao , Colorado J Reed , Xiaolong Wang , Kurt Keutzer , Trevor Darrell

Personalized ultra-fractionated stereotactic adaptive radiotherapy (PULSAR) is a novel treatment that delivers radiation in pulses of protracted intervals. Accurate prediction of gross tumor volume (GTV) changes through regression models…

Machine Learning · Computer Science 2025-09-18 Yajun Yu , Steve Jiang , Robert Timmerman , Hao Peng

Purpose: Delineating tumor boundaries during breast-conserving surgery is challenging as tumors are often highly mobile, non-palpable, and have irregularly shaped borders. To address these challenges, we introduce a cooperative robotic…

It has always been a big challenge to identify subtle changes in Electroencephalogram (EEG) signals. Minor differences often lead to vital decisions, for example, which grade a certain tumour belong to or whether a haemorrhage can result in…

Systems and Control · Electrical Eng. & Systems 2022-06-01 Debojyoti Seth

Chimeric antigen receptor T (CAR-T) cell therapy has emerged as a promising treatment for hematological malignancies, offering a targeted approach to cancer treatment. Understanding the complexities of CAR-T cell therapy within solid tumors…

Tissues and Organs · Quantitative Biology 2025-02-03 Silvia Bordel-Vozmediano , Soukaina Sabir , Lucía Benito-Barca , Bettina Weigelin , Víctor M. Pérez-García