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Host-pathogen interactions consist of an attack by the pathogen, frequently a defense by the host and possibly a counter-defense by the pathogen. Here, we present a game-theoretical approach to describing such interactions. We consider a…

Quantitative Methods · Quantitative Biology 2024-09-10 Shalu Dwivedi , Ravindra Garde , Stefan Schuster

Prokaryotes have evolved various mechanisms to counter viruses, which in their turn developed numerous strategies to avoid defenses of the hosts. Dozens of such defense and counter-defense mechanisms have recently been discovered, yet the…

Populations and Evolution · Quantitative Biology 2025-08-04 Yaroslav Ispolatov , Anna Lekontseva , Konstantin Severinov

We introduce a model called Host-Pathogen game for studying biological competitions. Notably, we focus on the invasive dynamics of external agents, like bacteria, within a host organism. The former are mapped to a population of defectors…

Populations and Evolution · Quantitative Biology 2018-09-03 Marco Alberto Javarone

Adversarial machine learning, i.e., increasing the robustness of machine learning algorithms against so-called adversarial examples, is now an established field. Yet, newly proposed methods are evaluated and compared under unrealistic…

Machine Learning · Computer Science 2021-09-28 Maximilian Samsinger , Florian Merkle , Pascal Schöttle , Tomas Pevny

We study defense strategies against reward poisoning attacks in reinforcement learning. As a threat model, we consider attacks that minimally alter rewards to make the attacker's target policy uniquely optimal under the poisoned rewards,…

Machine Learning · Computer Science 2021-06-22 Kiarash Banihashem , Adish Singla , Goran Radanovic

The development of reliable methods for restoring susceptibility after antibiotic resistance arises has proven elusive. A greater understanding of the relationship between antibiotic administration and the evolution of resistance is key to…

Populations and Evolution · Quantitative Biology 2014-06-09 Portia M. Mira , Kristina Crona , Devin Greene , Juan C. Meza , Bernd Sturmfels , Miriam Barlow

Inspired by scenarios where the strategic network design and defense or immunisation are of the central importance, Goyal et al. [3] defined a new Network Formation Game with Attack and Immunisation. The authors showed that despite the…

Computer Science and Game Theory · Computer Science 2023-02-13 Carme Àlvarez , Arnau Messegué

The adaptive immune system provides a diverse set of molecules that can mount specific responses against a multitude of pathogens. Memory is a key feature of adaptive immunity, which allows organisms to respond more readily upon…

Populations and Evolution · Quantitative Biology 2021-04-14 Oskar H Schnaack , Armita Nourmohammad

One strategy for winning a coevolutionary struggle is to evolve rapidly. Most of the literature on host-pathogen coevolution focuses on this phenomenon, and looks for consequent evidence of coevolutionary arms races. An alternative…

Populations and Evolution · Quantitative Biology 2012-11-14 Erick Chastain , Rustom Antia , Carl T. Bergstrom

Adversarial dynamics are a critical facet within the cyber security domain, in which there exists a co-evolution between attackers and defenders in any given threat scenario. While defenders leverage capabilities to minimize the potential…

Cryptography and Security · Computer Science 2014-08-19 Michael L. Winterrose , Kevin M. Carter

In a distributed system with {\it attacks} and {\it defenses,} both {\it attackers} and {\it defenders} are self-interested entities. We assume a {\it reward-sharing} scheme among {\it interdependent} defenders; each defender wishes to…

Computer Science and Game Theory · Computer Science 2008-12-23 Marios Mavronicolas , Burkhard Monien , Vicky Papadopoulou

One strategy for winning a coevolutionary struggle is to evolve rapidly. Most of the literature on host-pathogen coevolution focuses on this phenomenon, and looks for consequent evidence of coevolutionary arms races. An alternative…

Populations and Evolution · Quantitative Biology 2014-12-17 Erick Chastain , Rustom Antia , Carl T. Bergstrom

We establish some properties of a within host mathematical model of malaria proposed by Recker et al which includes the role of the immune system during the infection. The model accounts for the antigenic variation exhibited by the malaria…

Cell Behavior · Quantitative Biology 2007-08-01 Patrick De Leenheer , Sergei S. Pilyugin

We propose a scheme for defending against adversarial attacks by suppressing the largest eigenvalue of the Fisher information matrix (FIM). Our starting point is one explanation on the rationale of adversarial examples. Based on the idea of…

Machine Learning · Computer Science 2019-09-16 Chaomin Shen , Yaxin Peng , Guixu Zhang , Jinsong Fan

As large language models grow increasingly capable, concerns about their safe deployment have intensified. While numerous alignment strategies aim to restrict harmful behavior, these defenses can still be circumvented through carefully…

Computation and Language · Computer Science 2026-05-05 Xinbo Wu , Huan Zhang , Abhishek Umrawal , Lav R. Varshney

In Stackelberg security games when information about the attacker's payoffs is uncertain, algorithms have been proposed to learn the optimal defender commitment by interacting with the attacker and observing their best responses. In this…

Computer Science and Game Theory · Computer Science 2019-11-01 Jiarui Gan , Qingyu Guo , Long Tran-Thanh , Bo An , Michael Wooldridge

There are various examples of phenotypic plasticity in ecosystems that serve as the basis for a wide range of inducible defences against predation. These strategies include camouflage, burrowing, mimicry, evasive actions, and even…

Populations and Evolution · Quantitative Biology 2025-01-06 Sangeeta Saha , Swadesh Pal , Roderick Melnik

Many microbes live in habitats below their optimum temperature. Retention of metabolic heat by aggregation or insulation would boost growth. Generation of excess metabolic heat may also provide benefit. A cell that makes excess metabolic…

Populations and Evolution · Quantitative Biology 2020-10-22 Steven A. Frank

We develop a time and space dependent predator-prey model. The predators' equation is a non local hyperbolic balance law, while the diffusion of prey obeys a parabolic equation, so that predators "hunt" for prey, while prey diffuse. A…

Analysis of PDEs · Mathematics 2020-04-01 Rinaldo M. Colombo , Elena Rossi

This paper proposes a game-theoretic method to address the problem of optimal detector placement in a networked control system under cyber-attacks. The networked control system is composed of interconnected agents where each agent is…

Systems and Control · Electrical Eng. & Systems 2023-12-05 Anh Tung Nguyen , Sribalaji C. Anand , André M. H. Teixeira , Alexander Medvedev
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