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A central object in the computational studies of rare events is the committor function. Though costly to compute, the committor function encodes complete mechanistic information of the processes involving rare events, including reaction…

Statistical Mechanics · Physics 2022-11-23 Muhammad R. Hasyim , Clay H. Batton , Kranthi K. Mandadapu

Transition path theory (TPT) is a mathematical framework for quantifying rare transition events between a pair of selected metastable states $A$ and $B$. Central to TPT is the committor function, which describes the probability to hit the…

Numerical Analysis · Mathematics 2026-01-22 Zezheng Song , Maria K. Cameron , Haizhao Yang

Many algorithms for finding reaction pathways require an initial estimate of the minimum energy path (MEP). Most estimation methods use a variational approach and thus must be seeded from an even simpler path, such as one generated by…

Chemical Physics · Physics 2020-11-16 Mark C Palenik

Chemical reactions are often associated with an energy barrier along the reaction pathway which hinders the spontaneity of the reaction. Changing the energy barrier along the reaction pathway allows one to modulate the performance of a…

Computational Physics · Physics 2018-09-26 Sudipta Kundu , Satadeep Bhattacharjee , Seung-Cheol Lee , Manish Jain

Ensemble models of graphs are one of the most important theoretical tools to study complex networks. Among them, exponential random graphs (ERGs) have proven to be very useful in the analysis of social networks. In this paper we develop a…

Statistical Mechanics · Physics 2022-11-14 Diego Escribano , José A. Cuesta

Transient absorption spectroscopy (TAS) is among the most common ultrafast photochemical experiments, but its interpretation remains challenging. In this work, we present an efficient and robust method for simulating TAS signals from first…

Transition voltage spectroscopy (TVS) has recently been introduced as a spectroscopic tool for molecular junctions where it offers the possibility to probe molecular level energies at relatively low bias voltages. In this work we perform…

Mesoscale and Nanoscale Physics · Physics 2015-05-19 Jingzhe Chen , Troels Markussen , Kristian S. Thygesen

We study a scenario for route planning in road networks, where the objective to be optimized may change between every shortest path query. Since this invalidates many of the known speedup techniques for road networks that are based on…

Data Structures and Algorithms · Computer Science 2015-09-11 Julian Dibbelt , Ben Strasser , Dorothea Wagner

A comprehensive vehicular network analysis requires modeling the street system and vehicle locations. Even when Poisson point processes (PPPs) are used to model the vehicle locations on each street, the analysis is barely tractable. That…

Networking and Internet Architecture · Computer Science 2021-11-30 Jeya Pradha Jeyaraj , Martin Haenggi , Ahmed Hamdi Sakr , Hongsheng Lu

In the present work we introduce a computational approach to the absolute rovibrational quantum partition function using the path-integral formalism of quantum mechanics in combination with the nested sampling technique. The numerical…

Quantum Physics · Physics 2018-06-22 Bela Szekeres , Livia B. Partay , Edit Matyus

Cyber-Physical Production Systems (CPPSs), such as automated car manufacturing plants, execute a configurable sequence of production steps to manufacture products from a product portfolio. In CPPS engineering, domain experts start with…

Understanding how packets are routed in Internet is significantly important to Internet measurement and modeling. The conventional solution for route simulation is based on the assumption of unweighted shortest path. However, it has been…

Networking and Internet Architecture · Computer Science 2014-09-30 Mingming Chen , Jichang Zhao , Xiao Liang , Ke Xu

In Path Integral control problems a representation of an optimally controlled dynamical system can be formally computed and serve as a guidepost to learn a parametrized policy. The Path Integral Cross-Entropy (PICE) method tries to exploit…

Systems and Control · Electrical Eng. & Systems 2020-05-14 Dominik Thalmeier , Hilbert J. Kappen , Simone Totaro , Vicenç Gómez

We present a method to sample reactive pathways via biased molecular dynamics simulations in trajectory space. We show that the use of enhanced sampling techniques enables unconstrained exploration of multiple reaction routes. Time…

Computational Physics · Physics 2020-07-15 Davide Mandelli , Barak Hirshberg , Michele Parrinello

The committor functions are central to investigating rare but important events in molecular simulations. It is known that computing the committor function suffers from the curse of dimensionality. Recently, using neural networks to estimate…

Machine Learning · Statistics 2025-01-28 Yueyang Wang , Kejun Tang , Xili Wang , Xiaoliang Wan , Weiqing Ren , Chao Yang

Atomistic modelling of phase transitions, chemical reactions, or other rare events that involve overcoming high free energy barriers usually entails prohibitively long simulation times. Introducing a bias potential as a function of an…

Computational Physics · Physics 2019-11-06 Federico Giberti , Bingqing Cheng , Gareth Aneurin Tribello , Michele Ceriotti

Identifying transition states (TSs), the high-energy configurations that molecules pass through during chemical reactions, is essential for understanding and designing chemical processes. However, accurately and efficiently identifying…

Chemical Physics · Physics 2025-07-23 Samir Darouich , Vinh Tong , Tanja Bien , Johannes Kästner , Mathias Niepert

Transition pathways of stochastic dynamical systems are typically approximated by instantons. Here we show, using a dynamical system containing two competing pathways, that at low-to-intermediate temperatures, instantons can fail to capture…

Statistical Mechanics · Physics 2022-08-05 Lukas Kikuchi , Ronojoy Adhikari , Julian Kappler

Machine learning has emerged as a promising approach to path loss prediction, yet its effectiveness often degrades when measurement data are scarce. To address this limitation, we propose an ensemble-based machine learning framework that…

Signal Processing · Electrical Eng. & Systems 2026-05-26 Ahmed P. Mohamed , Byunghyun Lee , Yaguang Zhang , Christopher R. Anderson , David J. Love , James V. Krogmeier

We study rare transitions in Markovian open quantum systems driven with Gaussian noise, applying transition path and interface sampling methods to trajectories generated by stochastic Schr\"odinger dynamics. Interface and path sampling…

Quantum Physics · Physics 2025-05-09 Robson Christie , Peter G. Bolhuis , David T. Limmer