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Dense prediction tasks such as segmentation and detection of pathological entities hold crucial clinical value in computational pathology workflows. However, obtaining dense annotations on large cohorts is usually tedious and expensive.…

We propose adversarial constrained-CNN loss, a new paradigm of constrained-CNN loss methods, for weakly supervised medical image segmentation. In the new paradigm, prior knowledge is encoded and depicted by reference masks, and is further…

While total intracranial carotid artery calcification (ICAC) volume is an established stroke biomarker, growing evidence shows this aggregate metric ignores the critical influence of plaque location, since calcification in different…

Intracranial carotid artery calcification (ICAC) is a major risk factor for stroke, and might contribute to dementia and cognitive decline. Reliance on time-consuming manual annotation of ICAC hampers much demanded further research into the…

Deep learning models are widely recognized for their effectiveness in identifying medical image findings in disease classification. However, their limitations become apparent in the dynamic and ever-changing clinical environment,…

Difference-of-Convex (DC) minimization, referring to the problem of minimizing the difference of two convex functions, has been found rich applications in statistical learning and studied extensively for decades. However, existing methods…

This paper presents a method that improve state-of-the-art of the concave point detection methods as a first step to segment overlapping objects on images. It is based on the analysis of the curvature of the objects contour. The method has…

Rectal tumour segmentation in dynamic contrast-enhanced MRI (DCE-MRI) is a challenging task, and an automated and consistent method would be highly desirable to improve the modelling and prediction of patient outcomes from tissue contrast…

Submodular optimization has become a fundamental paradigm for data selection, retrieval, summarization, and representation learning due to its ability to model coverage, diversity, and representativeness. However, classical submodular…

Dice loss is widely used for medical image segmentation, and many improvement loss functions based on such loss have been proposed. However, further Dice loss improvements are still possible. In this study, we reconsidered the use of Dice…

Novel coordinate descent (CD) methods are proposed for minimizing nonconvex functions consisting of three terms: (i) a continuously differentiable term, (ii) a simple convex term, and (iii) a concave and continuous term. First, by extending…

Performance measurement is an essential task once a statistical model is created. The Area Under the receiving operating characteristics Curve (AUC) is the most popular measure for evaluating the quality of a binary classifier. In this…

Image segmentation is pivotal in medical image analysis, facilitating clinical diagnosis, treatment planning, and disease evaluation. Deep learning has significantly advanced automatic segmentation methodologies by providing superior…

Deep learning empowers the mainstream medical image segmentation methods. Nevertheless current deep segmentation approaches are not capable of efficiently and effectively adapting and updating the trained models when new incremental…

We present a deep learning segmentation model that can automatically and robustly segment all major anatomical structures in body CT images. In this retrospective study, 1204 CT examinations (from the years 2012, 2016, and 2020) were used…

Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) is a valuable tool to localize, characterize, and evaluate anomalous prostate tissue. Ultrafast gradient-echo acquisitions of MRI volumes are generated at regular time intervals…

Automated deduction seeks to enable machines to reason with mathematical precision and logical completeness. Classical resolution-based systems, such as Prover9, E, and Vampire, rely on binary inference, which inherently limits multi-clause…

Given $iid$ observations from an unknown absolute continuous distribution defined on some domain $\Omega$, we propose a nonparametric method to learn a piecewise constant function to approximate the underlying probability density function.…

Accurate segmentation of lung cancer in pathology slides is a critical step in improving patient care. We proposed the ACDC@LungHP (Automatic Cancer Detection and Classification in Whole-slide Lung Histopathology) challenge for evaluating…

Hippocampus segmentation plays a key role in diagnosing various brain disorders such as Alzheimer's disease, epilepsy, multiple sclerosis, cancer, depression and others. Nowadays, segmentation is still mainly performed manually by…