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The volume under the receiver operating characteristic surface (VUS) is useful for measuring the overall accuracy of a diagnostic test when the possible disease status belongs to one of three ordered categories. In medical studies, the VUS…

Methodology · Statistics 2018-07-03 Khanh To Duc , Monica Chiogna , Gianfranco Adimari

Verification bias is a well known problem when the predictive ability of a diagnostic test has to be evaluated. In this paper, we discuss how to assess the accuracy of continuous-scale diagnostic tests in the presence of verification bias,…

Methodology · Statistics 2016-04-19 Khanh To Duc , Monica Chiogna , Gianfranco Adimari

Verification bias is a well-known problem that may occur in the evaluation of predictive ability of diagnostic tests. When a binary disease status is considered, various solutions can be found in the literature to correct inference based on…

Methodology · Statistics 2023-04-10 Khanh To Duc , Monica Chiogna , Gianfranco Adimari

The Receiver Operating Characteristic (ROC) surface is a generalization of ROC curve and is widely used for assessment of the accuracy of diagnostic tests on three categories. A complication called the verification bias, meaning that not…

Applications · Statistics 2018-03-20 Rui Zhu , Subhashis Ghosal

The accuracy of a diagnostic test is typically characterised using the receiver operating characteristic (ROC) curve. Summarising indexes such as the area under the ROC curve (AUC) are used to compare different tests as well as to measure…

Methodology · Statistics 2010-12-30 Fang Yao , Radu V. Craiu , Benjamin Reiser

This article considers the receiver operating characteristic (ROC) curve analysis for medical data with non-ignorable missingness in the disease status. In the framework of the logistic regression models for both the disease status and the…

Methodology · Statistics 2024-11-27 Dingding Hu , Tao Yu , Pengfei Li

Many problems that appear in biomedical decision making, such as diagnosing disease and predicting response to treatment, can be expressed as binary classification problems. The costs of false positives and false negatives vary across…

The area under the ROC curve (AUC) is the standard measure of a biomarker's discriminatory accuracy; however, naive AUC estimates can be misleading when validation cohorts differ from the intended target population. Such covariate shifts…

Methodology · Statistics 2025-11-20 Jiajun Liu , Guangcai Mao , Xiaofei Wang

The area under the ROC curve (AUC) is a widely used performance measure in machine learning. Increasingly, however, in several applications, ranging from ranking to biometric screening to medicine, performance is measured not in terms of…

Machine Learning · Computer Science 2016-11-29 Harikrishna Narasimhan , Shivani Agarwal

The receiver operating characteristic (ROC) curve is a very useful tool for analyzing the diagnostic/classification power of instruments/classification schemes as long as a binary-scale gold standard is available. When the gold standard is…

Methodology · Statistics 2011-05-10 Zhanfeng Wang , Yuan-chin Ivan Chang

In diagnostic studies, researchers frequently encounter imperfect reference standards with some misclassified labels. Treating these as gold standards can bias receiver operating characteristic (ROC) curve analysis. To address this issue,…

Methodology · Statistics 2025-02-13 Yifan Sun , Peijun Sang , Qinglong Tian , Pengfei Li

Accurate diagnosis of disease is of great importance in clinical practice and medical research. The receiver operating characteristic (ROC) surface is a popular tool for evaluating the discriminatory ability of continuous diagnostic test…

Methodology · Statistics 2018-05-22 Vanda Inacio de Carvalho , Miguel de Carvalho , Adam Branscum

When evaluating medical tests or biomarkers for disease classification, the area under the receiver-operating characteristic (ROC) curve is a widely used performance metric that does not require us to commit to a specific decision…

Methodology · Statistics 2013-10-21 Wanhua Su , Yan Yuan , Mu Zhu

The ROC curve is widely used to assess binary classifiers. Yet for some applications, such as alert systems for monitoring hospitalized patients, conventional ROC analysis cannot meet two key deployment needs: enforcing a constraint on…

Machine Learning · Computer Science 2026-04-03 Christopher Ratigan , Kyle Heuton , Carissa Wang , Lenore Cowen , Michael C. Hughes

To assess the classification accuracy of a continuous diagnostic result, the receiver operating characteristic (ROC) curve is commonly used in applications. The partial area under the ROC curve (pAUC) is one of widely accepted summary…

Applications · Statistics 2011-03-11 Hung Hung , Chin-Tsang Chiang

While the area under the ROC curve is perhaps the most common measure that is used to rank the relative performance of different binary classifiers, longstanding field folklore has noted that it can be a measure that ill-captures the…

Machine Learning · Computer Science 2024-12-19 Christopher Ratigan , Lenore Cowen

Estimating average human performance has been performed inconsistently in research in diagnostic medicine. This has been particularly apparent in the field of medical artificial intelligence, where humans are often compared against AI…

Methodology · Statistics 2020-09-28 Luke Oakden-Rayner , Lyle Palmer

The Receiver Operating Characteristic (ROC) curve and the Area Under the Curve (AUC) of the ROC curve are widely used to compare the performance of diagnostic and prognostic assays. The ROC curve has the advantage that it is independent of…

Optimal performance is critical for decision-making tasks from medicine to autonomous driving, however common performance measures may be too general or too specific. For binary classifiers, diagnostic tests or prognosis at a timepoint,…

Accurate diagnosis of disease is of fundamental importance in clinical practice and medical research. Before a medical diagnostic test is routinely used in practice, its ability to distinguish between diseased and nondiseased states must be…

Methodology · Statistics 2018-06-05 Vanda Inacio de Carvalho , Maria Xose Rodriguez-Alvarez
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