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A Bayesian feature allocation model (FAM) is presented for identifying cell subpopulations based on multiple samples of cell surface or intracellular marker expression level data obtained by cytometry by time of flight (CyTOF). Cell…

Applications · Statistics 2020-02-21 Arthur Lui , Juhee Lee , Peter F. Thall , May Daher , Katy Rezvani , Rafet Barar

Diffusion models and flow matching have demonstrated remarkable success in text-to-image generation. While many existing alignment methods primarily focus on fine-tuning pre-trained generative models to maximize a given reward function,…

Machine Learning · Statistics 2026-02-03 Yidong Ouyang , Liyan Xie , Hongyuan Zha , Guang Cheng

A sequential estimator based on the Ensemble Kalman Filter for Data Assimilation of fluid flows is presented in this research work. The main feature of this estimator is that the Kalman filter update, which relies on the determination of…

Computational Engineering, Finance, and Science · Computer Science 2021-07-28 Gabriel Moldovan , Guillame Lehnasch , Laurent Cordier , Marcello Meldi

Antibodies, crucial for immune defense, primarily rely on complementarity-determining regions (CDRs) to bind and neutralize antigens, such as viruses. The design of these CDRs determines the antibody's affinity and specificity towards its…

Quantitative Methods · Quantitative Biology 2024-09-10 Paulina Kulytė , Francisco Vargas , Simon Valentin Mathis , Yu Guang Wang , José Miguel Hernández-Lobato , Pietro Liò

Synthetic electrocardiogram generation serves medical AI applications requiring privacy-preserving data sharing and training dataset augmentation. Current diffusion-based methods achieve high generation quality but require hundreds of…

Signal Processing · Electrical Eng. & Systems 2025-09-16 Vitalii Bondar , Serhii Semenov , Vira Babenko , Dmytro Holovniak

Causal mediation analysis, pleiotropy analysis, and replication analysis are three highly popular genetic study designs. Although these analyses address different scientific questions, the underlying inference problems all involve…

Methodology · Statistics 2023-09-25 Ryan Sun , Zachary McCaw , Xihong Lin

In this article, we introduce the new approach "fluorescence grid based aggregation (FGBA)" to justify a dynamical model of protein expression using experimental fluorescence histograms. In this approach, first, we describe the dynamics of…

Probability · Mathematics 2015-03-19 Anahita Mirtabatabaei , Francesco Bullo , Mustafa Khammash

The ocean is filled with microscopic microalgae called phytoplankton, which together are responsible for as much photosynthesis as all plants on land combined. Our ability to predict their response to the warming ocean relies on…

Applications · Statistics 2022-08-05 Sangwon Hyun , Mattias Rolf Cape , Francois Ribalet , Jacob Bien

We introduce $\texttt{PairFlow}$, a lightweight preprocessing step for training Discrete Flow Models (DFMs) to achieve few-step sampling without requiring a pretrained teacher. DFMs have recently emerged as a new class of generative models…

Machine Learning · Computer Science 2026-05-26 Mingue Park , Jisung Hwang , Seungwoo Yoo , Kyeongmin Yeo , Minhyuk Sung

This paper presents a simple, effective, and cost-efficient strategy to improve LLM performance by scaling test-time compute. Our strategy builds upon the repeated-sampling-then-voting framework, with a novel twist: incorporating multiple…

Artificial Intelligence · Computer Science 2025-11-11 Jianhao Chen , Zishuo Xun , Bocheng Zhou , Han Qi , Hangfan Zhang , Qiaosheng Zhang , Yang Chen , Wei Hu , Yuzhong Qu , Wanli Ouyang , Shuyue Hu

Various modifications of decision trees have been extensively used during the past years due to their high efficiency and interpretability. Tree node splitting based on relevant feature selection is a key step of decision tree learning, at…

Machine Learning · Computer Science 2017-09-05 Dmitry Ignatov , Andrey Ignatov

Recent advances in few-step diffusion distillation have enabled efficient image generation, yet aligning these models with human preferences remains challenging. We propose Reward-Tilted Distribution Matching Distillation (RTDMD), a…

Computer Vision and Pattern Recognition · Computer Science 2026-05-29 Yushi Huang , Xiangxin Zhou , Ruoyu Wang , Chi Zhang , Jun Zhang , Tianyu Pang

Flow matching casts sample generation as learning a continuous-time velocity field that transports noise to data. Existing flow matching networks typically predict each point's velocity independently, considering only its location and time…

Machine Learning · Computer Science 2025-11-11 Md Shahriar Rahim Siddiqui , Moshe Eliasof , Eldad Haber

Ocean microbes are critical to both ocean ecosystems and the global climate. Flow cytometry, which measures cell optical properties in fluid samples, is routinely used in oceanographic research. Despite decades of accumulated data,…

Methodology · Statistics 2025-04-17 Sangwon Hyun , Tim Coleman , Francois Ribalet , Jacob Bien

This paper introduces LMFAO (Layered Multiple Functional Aggregate Optimization), an in-memory optimization and execution engine for batches of aggregates over the input database. The primary motivation for this work stems from the…

Databases · Computer Science 2019-06-21 Maximilian Schleich , Dan Olteanu , Mahmoud Abo Khamis , Hung Q. Ngo , XuanLong Nguyen

Present day computational fluid dynamics simulations generate extremely large amounts of data, sometimes on the order of TB/s. Often, a significant fraction of this data is discarded because current storage systems are unable to keep pace.…

Computational Engineering, Finance, and Science · Computer Science 2021-03-03 Heather Pacella , Alec Dunton , Alireza Doostan , Gianluca Iaccarino

The group testing problem asks for efficient pooling schemes and algorithms that allow to screen moderately large numbers of samples for rare infections. The goal is to accurately identify the infected samples while conducting the least…

Artificial Intelligence · Computer Science 2021-05-19 AminCoja-Oghlan , Max Hahn-Klimroth , Philipp Loick , Manuel Penschuck

Identifying subgroups of patients with an enhanced response to a new treatment has become an area of increased interest in the last few years. When there is knowledge about possible subpopulations with an enhanced treatment effect before…

Methodology · Statistics 2018-11-27 Marius Thomas , Björn Bornkamp , Martin Posch , Franz König

Flow matching has emerged as a promising framework for training generative models, demonstrating impressive empirical performance while offering relative ease of training compared to diffusion-based models. However, this method still…

Computer Vision and Pattern Recognition · Computer Science 2026-03-31 Quan Dao , Hao Phung , Trung Dao , Dimitris Metaxas , Anh Tran

Continuous diffusion and flow matching models could represent a powerful alternative to autoregressive approaches for language modelling (LM), as they unlock a host of advantages currently reserved for continuous modalities, including…

Machine Learning · Computer Science 2026-05-12 Oscar Davis , Anastasiia Filippova , Pierre Ablin , Victor Turrisi , Amitis Shidani , Marco Cuturi , Louis Béthune