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The physiology of voltage gated ion channels is complex and insights into their gating mechanism is incomplete. Their function is best represented by Markov models with relatively large number of distinct states that are connected by…
We propose a neural network model of multi-neuron interacting system that simulates neurons to interact each other through the surroundings of neuronal cell bodies. We physically model the neuronal cell surroundings, include the dendrites,…
The Hodgkin-Huxley model describes action potential generation in certain types of neurons and is a standard model for conductance-based, excitable cells. Following the early work of Winfree and Best, this paper explores the response of a…
This article is devoted to the theoretical and numerical analysis of a network of excitatory and inhibitory neurons of Hodgkin-Huxley (HH) type, for which the topology is inspired by that of a single local layer of visual cortex V1. Our…
A quantized physical framework, called the five-anchor model, is developed for a general understanding of the working mechanism of ion channels. According to the hypotheses of this model, the following two basic physical principles are…
We study a dephasing channel with memory, described by a Hamiltonian model in which the system-environment interaction is described by a stochastic process. We propose a useful way to describe the channel uses correlations. Moreover, we…
Even the most sophisticated artificial neural networks are built by aggregating substantially identical units called neurons. A neuron receives multiple signals, internally combines them, and applies a non-linear function to the resulting…
We study the frequency and phase synchronization in two coupled identical and nonidentical neurons with channel noise. The occupation number method is used to model the neurons in the context of stochastic Hodgkin-Huxley model in which the…
We analyze the response of the Hodgkin-Huxley neuron to a large number of uncorrelated stochastic inhibitory and excitatory post-synaptic spike trains. In order to clarify the various mechanisms responsible for noise-induced spike…
We introduce an approximation scheme for the Hodgkin-Huxley model of nerve conductance which allows to calculate both the speed of the traveling pulses and their shape in quantitative agreement with the solutions of the model. We…
In recent years, many difficulties appeared when taking into account the inherent stochastic behavior of neurons and voltage-dependent ion channels in Hodgking-Huxley type models. In particular, an open problem for a stochastic model of…
The dynamics of a multiplex heterogeneous network of oscillators is studied. Two types of similar models based on the Hodgkin-Huxley formalism are used as the basic elements of the networks. The first type model demonstrates bursting…
By means of the concepts of factorial moment, return map and NM estimator, we analyze some responses of a HH neuron to various types of spike-train inputs. The corresponding fractal dimensions and values of NM estimators can describe the…
We consider a system of two-level quantum quasi-spins and gauge bosons put on a 3+1D lattice. As a model of neural network of the brain functions, these spins describe neurons quantum-mechanically, and the gauge bosons describes weights of…
Based on numerical simulation of Hodgkin and Huxley type neuron stimulated from many synaptic inputs, an abstract concept of signal processing in individual neuron is proposed. In the concept proposed, neuron performs binding of synaptic…
We present a neural network approach for closed-loop deep brain stimulation (DBS). We cast the problem of finding an optimal neurostimulation strategy as a control problem. In this setting, control policies aim to optimize therapeutic…
In this paper we deal with a feedback control design for the action potential of a neuronal membrane in relation with the non-linear dynamics of the Hodgkin-Huxley mathematical model. More exactly, by using an external current as a control…
The influence of intrinsic channel noise on the spontaneous spiking activity of poisoned excitable membrane patches is studied by use of a stochastic generalization of the Hodgkin-Huxley model. Internal noise stemming from the stochastic…
Action potential generation underlies some of the most consequential dynamical systems on Earth, from brains to hearts. It is therefore interesting to develop synthetic cell-free systems, based on the same molecular mechanisms, which may…
Most models of neurons incorporate a capacitor to account for the marked capacitive behavior exhibited by the cell membrane. However, such capacitance is widely considered constant, thereby neglecting the possible effects of time-dependent…