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In this paper, we studied the association between the change of structural brain volumes to the potential development of Alzheimer's disease (AD). Using a simple abstraction technique, we converted regional cortical and subcortical volume…

Image and Video Processing · Electrical Eng. & Systems 2019-05-16 Rui Zhang , Luca Giancardo , Danilo A. Pena , Yejin Kim , Hanghang Tong , Xiaoqian Jiang

This paper considers the problem of brain disease classification based on connectome data. A connectome is a network representation of a human brain. The typical connectome classification problem is very challenging because of the small…

Machine Learning · Statistics 2020-01-24 Nikita Mokrov , Maxim Panov , Boris A. Gutman , Joshua I. Faskowitz , Neda Jahanshad , Paul M. Thompson

Magnetic Resonance Imaging (MRI) plays a pivotal role in the early diagnosis and monitoring of Alzheimer's disease (AD). However, the subtle structural variations in brain MRI scans often pose challenges for conventional deep learning…

Image and Video Processing · Electrical Eng. & Systems 2025-12-22 Faisal Ahmed

Background:Cognitive assessments represent the most common clinical routine for the diagnosis of Alzheimer's Disease (AD). Given a large number of cognitive assessment tools and time-limited office visits, it is important to determine a…

Quantitative Methods · Quantitative Biology 2020-11-16 Bo Peng , Xiaohui Yao , Shannon L. Risacher , Andrew J. Saykin , Li Shen , Xia Ning

The concept of biological age (BA), although important in clinical practice, is hard to grasp mainly due to the lack of a clearly defined reference standard. For specific applications, especially in pediatrics, medical image data are used…

Image and Video Processing · Electrical Eng. & Systems 2021-03-22 Karim Armanious , Sherif Abdulatif , Wenbin Shi , Shashank Salian , Thomas Küstner , Daniel Weiskopf , Tobias Hepp , Sergios Gatidis , Bin Yang

Alzheimer's Disease (AD) is a progressive neurological disorder that can result in significant cognitive impairment and dementia. Accurate and timely diagnosis is essential for effective treatment and management of this disease. In this…

Image and Video Processing · Electrical Eng. & Systems 2024-12-10 Mozhgan Naderi , Maryam Rastgarpour , Amir Reza Takhsha

Brain age estimation from Magnetic Resonance Images (MRI) derives the difference between a subject's biological brain age and their chronological age. This is a potential biomarker for neurodegeneration, e.g. as part of Alzheimer's disease.…

Computer Vision and Pattern Recognition · Computer Science 2020-10-02 Kyriaki-Margarita Bintsi , Vasileios Baltatzis , Arinbjörn Kolbeinsson , Alexander Hammers , Daniel Rueckert

We propose a disease classification model, called the QC-SPHARM, for the early detection of the Alzheimer's Disease (AD). The proposed QC-SPHARM can distinguish between normal control (NC) subjects and AD patients, as well as between…

Image and Video Processing · Electrical Eng. & Systems 2020-03-24 Anthony Hei-Long Chan , Yishan Luo , Lin Shi , Ronald Lok-Ming Lui

As a general and robust alternative to traditional mean regression models, quantile regression avoids the assumption of normally distributed errors, making it a versatile choice when modeling outcomes such as cognitive scores that typically…

Methodology · Statistics 2026-03-19 Rongke Lyu , Marina Vannucci , Suprateek Kundu

Alzheimer's disease is a progressive neurodegenerative disorder that gradually deprives the patient of cognitive function and can end in death. With the advancement of technology today, it is possible to detect Alzheimer's disease through…

Image and Video Processing · Electrical Eng. & Systems 2022-07-05 Muhammad Wildan Oktavian , Novanto Yudistira , Achmad Ridok

We propose an interpretable 3D Grid-Attention deep neural network that can accurately predict a person's age and whether they have Alzheimer's disease (AD) from a structural brain MRI scan. Building on a 3D convolutional neural network, we…

Tissues and Organs · Quantitative Biology 2020-11-19 Pradeep Lam , Alyssa H. Zhu , Iyad Ba Gari , Neda Jahanshad , Paul M. Thompson

In the past decade, there has been a surge in research examining the use of voice and speech analysis as a means of detecting neurodegenerative diseases such as Alzheimer's. Many studies have shown that certain acoustic features can be used…

Audio and Speech Processing · Electrical Eng. & Systems 2023-07-20 Vrindha M. K. , Geethu V. , Anurenjan P. R. , Deepak S. , Sreeni K. G.

Alzheimer's disease (AD), a degenerative brain condition, can benefit from early prediction to slow its progression. As the disease progresses, patients typically undergo brain atrophy. Current prediction methods for Alzheimers disease…

Computer Vision and Pattern Recognition · Computer Science 2025-11-27 Xin Honga , Jie Lin , Minghui Wang

Prediction of the cognitive evolution of a person susceptible to develop a neurodegenerative disorder is crucial to provide an appropriate treatment as soon as possible. In this paper we propose a 3D siamese network designed to extract…

Image and Video Processing · Electrical Eng. & Systems 2019-09-04 Cecilia Ostertag , Marie Beurton-Aimar , Thierry Urruty

Early detection of Alzheimer's Disease (AD) and its prodromal state, Mild Cognitive Impairment (MCI), is crucial for providing suitable treatment and preventing the disease from progressing. It can also aid researchers and clinicians to…

Image and Video Processing · Electrical Eng. & Systems 2023-05-02 Arunima Jaiswal , Ananya Sadana

Quantum machine learning is a new research field combining quantum information science and machine learning. Quantum computing technologies appear to be particularly well-suited for addressing problems in the health sector efficiently. They…

Emerging Technologies · Computer Science 2024-12-24 Giacomo Cappiello , Filippo Caruso

Deep learning models have achieved state-of-the-art results in estimating brain age, which is an important brain health biomarker, from magnetic resonance (MR) images. However, most of these models only provide a global age prediction, and…

Image and Video Processing · Electrical Eng. & Systems 2023-08-25 Neha Gianchandani , Mahsa Dibaji , Mariana Bento , Ethan MacDonald , Roberto Souza

Alzheimer's disease (AD) is one of the most common public health issues the world is facing today. This disease has a high prevalence primarily in the elderly accompanying memory loss and cognitive decline. AD detection is a challenging…

Image and Video Processing · Electrical Eng. & Systems 2022-04-04 Zahraa Sh. Aaraji , Hawraa H. Abbas

Alzheimer's disease is a neurogenerative disease that alters memories, cognitive functions leading to death. Early diagnosis of the disease, by detection of the preliminary stage, called Mild Cognitive Impairment (MCI), remains a…

Image and Video Processing · Electrical Eng. & Systems 2020-12-03 Achraf Ben Miled , Taoufik Yeferny , Amira ben Rabeh

The reconstruction of cerebral cortex surfaces from brain MRI scans is instrumental for the analysis of brain morphology and the detection of cortical thinning in neurodegenerative diseases like Alzheimer's disease (AD). Moreover, for a…

Neurons and Cognition · Quantitative Biology 2022-10-05 Anne-Marie Rickmann , Fabian Bongratz , Sebastian Pölsterl , Ignacio Sarasua , Christian Wachinger
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