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Transition state theory is a standard framework for predicting the rate of a chemical reaction. Although the transition state theory has been successfully applied to numerous chemical reaction analyses, many experimental and theoretical…

Sampled structure sequences obtained, for instance, from real-time reactivity explorations or first-principles molecular dynamics simulations contain valuable information about chemical reactivity. Eventually, such sequences allow for the…

Chemical Physics · Physics 2018-04-25 Michael A. Heuer , Alain C. Vaucher , Moritz P. Haag , Markus Reiher

Individual components such as cells, particles, or agents within a larger system often require detailed understanding of their relative position to act accordingly, enabling the system as a whole to function in an organised and efficient…

Statistical Mechanics · Physics 2025-02-28 Jonas Berx , Prashant Singh , Karel Proesmans

Optimal power flow (OPF) is a critical optimization problem for power systems to operate at points where cost or other operational objectives are optimized. Due to the non-convexity of the set of feasible OPF operating points, it is…

Optimization and Control · Mathematics 2025-03-03 Daniel Turizo , Diego Cifuentes , Anton Leykin , Daniel K. Molzahn

Consider a path of non-degenerate eigenstates of unitary operators or Hamiltonians with minimum eigenvalue gap G. The eigenpath traversal problem is to transform one or more copies of the initial to the final eigenstate. Solutions to this…

Quantum Physics · Physics 2015-03-17 S. Boixo , E. Knill , R. D. Somma

Simulating rare events, such as the transformation of a reactant into a product in a chemical reaction typically requires enhanced sampling techniques that rely on heuristically chosen collective variables (CVs). We propose using…

Elementary flux modes (EFMs) are pathways through a metabolic reaction network that connect external substrates to products. Using EFMs, a metabolic network can be transformed into its macroscopic counterpart, in which the internal…

Optimization and Control · Mathematics 2014-10-13 Hildur Æsa Oddsdóttir , Erika Hagrot , Véronique Chotteau , Anders Forsgren

We introduce a computational framework for generating realistic transition paths between distinct conformations of large bio-molecular systems. The method is built on a stochastic integro-differential formulation derived from the Langevin…

Biomolecules · Quantitative Biology 2025-12-02 Patrice Koehl , Marc Delarue , Henri Orland

Global optimization of crystal compositions is a significant yet computationally intensive method to identify stable structures within chemical space. The specific physical properties linked to a three-dimensional atomic arrangement make…

We introduce a new numerical method to approximate the solutions of a class of stationary Hamilton-Jacobi (HJ) partial differential equations arising from minimum time optimal control problems. We rely on nested grid approximations, and…

Optimization and Control · Mathematics 2024-07-10 Marianne Akian , Stéphane Gaubert , Shanqing Liu

We study episodic linear mixture MDPs with the unknown transition and adversarial rewards under full-information feedback, employing dynamic regret as the performance measure. We start with in-depth analyses of the strengths and limitations…

Machine Learning · Computer Science 2024-11-06 Long-Fei Li , Peng Zhao , Zhi-Hua Zhou

Markov Decision Processes (MDP) is an useful framework to cast optimal sequential decision making problems. Given any MDP the aim is to find the optimal action selection mechanism i.e., the optimal policy. Typically, the optimal policy…

Systems and Control · Computer Science 2014-03-18 Chandrashekar Lakshminarayanan , Shalabh Bhatnagar

We analyze the efficiency of different methods for the calculation of reaction rates in the case of two simple analytical benchmark systems. Two classes of methods are considered: the first are based on the free energy calculation along a…

Statistical Mechanics · Physics 2009-11-11 Titus S. van Erp

The phase behavior and kinetic pathways of Li1+xV3O8 are investigated by means of density functional theory (DFT) and a cluster expansion (CE) methodology that approximates the system Hamiltonian in order to identify the lowest energy…

Materials Science · Physics 2013-05-30 Tonghu Jiang , Michael L. Falk

Transform Invariant Low-rank Textures (TILT) is a novel and powerful tool that can effectively rectify a rich class of low-rank textures in 3D scenes from 2D images despite significant deformation and corruption. The existing algorithm for…

Computer Vision and Pattern Recognition · Computer Science 2013-01-30 Xiang Ren , Zhouchen Lin

Identifying low-energy adsorption geometries on catalytic surfaces is a practical bottleneck for computational heterogeneous catalysis: the difficulty lies not only in the cost of density functional theory (DFT) but in proposing initial…

Machine Learning · Computer Science 2026-02-24 Jiangjie Qiu , Wentao Li , Honghao Chen , Leyi Zhao , Xiaonan Wang

Computational chemistry has become an indispensable tool for generating data and insights, pervading all branches of experimental chemistry. Its most central concept is the potential energy hypersurface, key to all chemistry and materials…

Chemical Physics · Physics 2026-04-03 Raphael T. Husistein , Markus Reiher

This paper develops some basic principles to study autocatalytic networks and exploit their structural properties in order to characterize their inherent fundamental limits and tradeoffs. In a dynamical system with autocatalytic structure,…

Systems and Control · Computer Science 2017-06-30 Milad Siami , Nader Motee , Gentian Buzi , Bassam Bamieh , Mustafa Khammash , John C. Doyle

Accurately modeling chemical reactions at the atomistic level requires high-level electronic structure theory due to the presence of unpaired electrons and the need to properly describe bond breaking and making energetics. Commonly used…

Low-rank representation (LRR) is an effective method for subspace clustering and has found wide applications in computer vision and machine learning. The existing LRR solver is based on the alternating direction method (ADM). It suffers…

Optimization and Control · Mathematics 2011-09-05 Zhouchen Lin , Risheng Liu , Zhixun Su