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The role of brain hemodynamics in neurodegenerative diseases cannot be fully assessed using existing imaging technologies. Recently, 2D Dynamic Ultrasound Localization Microscopy (DULM) has allowed for the quantitative mapping of the…

Parametric imaging is a compartmental approach that processes nuclear imaging data to estimate the spatial distribution of the kinetic parameters governing tracer flow. The present paper proposes a novel and efficient computational method…

Numerical Analysis · Mathematics 2018-08-21 Mara Scussolini , Sara Garbarino , Gianmario Sambuceti , Giacomo Caviglia , Michele Piana

Single-bed whole-body positron emission tomography based on resistive plate chamber detectors (RPC-PET) has been proposed for human studies, as a complementary resource to scintillator-based PET scanners. The purpose of this work is mainly…

Generative artificial intelligence (AI) has been playing an important role in various domains. Leveraging its high capability to generate high-fidelity and diverse synthetic data, generative AI is widely applied in diagnostic tasks, such as…

Computer Vision and Pattern Recognition · Computer Science 2025-11-24 Yifan Jiang , Ahmad Shariftabrizi , Venkata SK. Manem

Computed Tomography (CT) is a vital diagnostic tool in clinical practice, yet the health risks associated with ionizing radiation cannot be overlooked. Low-dose CT (LDCT) helps mitigate radiation exposure but simultaneously leads to reduced…

Computer Vision and Pattern Recognition · Computer Science 2025-11-20 Guoliang Gong , Man Yu

Background: Three-dimensional, whole heart, balanced steady state free precession (WH-bSSFP) sequences provide delineation of intra-cardiac and vascular anatomy. However, they have long acquisition times. Here, we propose significant speed…

Image and Video Processing · Electrical Eng. & Systems 2019-12-24 Jennifer A. Steeden , Michael Quail , Alexander Gotschy , Andreas Hauptmann , Simon Arridge , Rodney Jones , Vivek Muthurangu

Purpose: To develop a reconstruction framework for 3D real-time cine cardiovascular magnetic resonance (CMR) from highly undersampled data without requiring fully sampled training datasets. Methods: We developed a multi-dynamic low-rank…

Image and Video Processing · Electrical Eng. & Systems 2025-12-08 Chong Chen , Marc Vornehm , Zhenyu Bu , Preethi Chandrasekaran , Muhammad A. Sultan , Syed M. Arshad , Yingmin Liu , Yuchi Han , Rizwan Ahmad

Purpose: This work aims to develop an image reconstruction algorithm for wide-angle digital breast tomosynthesis (DBT) that has improved depth resolution and in-plane contrast while reducing non-uniformity artifacts. Approach: The image…

Optimization and Control · Mathematics 2026-05-29 Emil Y. Sidky , Adrian A. Sanchez , John Paul Phillips , Zheng Zhang , Dan Xia , Ingrid S. Reiser , Xiaochuan Pan

Computed tomography (CT) has been a powerful diagnostic tool since its emergence in the 1970s. Using CT data, three-dimensional (3D) structures of human internal organs and tissues, such as blood vessels, can be reconstructed using…

Applications · Statistics 2024-04-01 Qianhan Zeng , Jing Zhou , Ying Ji , Hansheng Wang

Positron emission tomography (PET) is widely utilized for cancer detection due to its ability to visualize functional and biological processes in vivo. PET images are usually reconstructed from histogrammed raw data (sinograms) using…

Image and Video Processing · Electrical Eng. & Systems 2024-11-26 Yiran Sun , Osama Mawlawi

The kernel reconstruction is a method that reduces noise in dynamic positron emission tomography (PET) by exploiting spatial correlations in the PET image. Although this method works well for large anatomical regions with relatively slow…

Medical Physics · Physics 2025-07-31 Alan Miranda , Steven Staelens

A novel neural network architecture, known as DL-ESPIRiT, is proposed to reconstruct rapidly acquired cardiac MRI data without field-of-view limitations which are present in previously proposed deep learning-based reconstruction frameworks.…

Signal Processing · Electrical Eng. & Systems 2020-05-20 Christopher M. Sandino , Peng Lai , Shreyas S. Vasanawala , Joseph Y. Cheng

Abstract Objective. Cone-beam computed tomography is becoming more and more popular in applications such as 3D dental imaging. Iterative methods compared to the standard Feldkamp algorithm have shown improvements in image quality of…

Signal Processing · Electrical Eng. & Systems 2024-11-15 Louise Friot-Giroux , Françoise Peyrin , Voichita Maxim

Statistical iterative reconstruction is expected to improve the image quality of megavoltage computed tomography (MVCT). However, one of the challenges of iterative reconstruction is its large computational cost. The purpose of this work is…

As a sensitive functional imaging technique, positron emission tomography (PET) plays a critical role in early disease diagnosis. However, obtaining a high-quality PET image requires injecting a sufficient dose (standard dose) of…

Image and Video Processing · Electrical Eng. & Systems 2024-12-06 Caiwen Jiang , Mianxin Liu , Kaicong Sun , Dinggang Shen

Electron tomography has achieved higher resolution and quality at reduced doses with recent advances in compressed sensing. Compressed sensing (CS) theory exploits the inherent sparse signal structure to efficiently reconstruct…

Computational Physics · Physics 2020-12-02 Jonathan Schwartz , Huihuo Zheng , Marcus Hanwell , Yi Jiang , Robert Hovden

Fourier Ptychographic Microscopy (FPM) is a computational imaging technique that enables high-resolution imaging over a large field of view. However, its application in the biomedical field has been limited due to the long image…

Image and Video Processing · Electrical Eng. & Systems 2024-08-27 Ruiqing Sun , Delong Yang , Yiyan Su , Shaohui Zhang , Qun Hao

The objective of this study was to develop a PET tumor-segmentation framework that addresses the challenges of limited spatial resolution, high image noise, and lack of clinical training data with ground-truth tumor boundaries in PET…

For single source helical Computed Tomography (CT), both Filtered-Back Projection (FBP) and statistical iterative reconstruction have been investigated. However for dual source CT with flying focal spot (DS-FFS CT), statistical iterative…

Image and Video Processing · Electrical Eng. & Systems 2022-02-14 Xiao Wang , Robert D. MacDougall , Peng Chen , Charles A. Bouman , Simon K. Warfield

Expectation-maximization (EM) is a popular and well-established method for image reconstruction in positron emission tomography (PET) but it often suffers from slow convergence. Ordered subset EM (OSEM) is an effective reconstruction…

Medical Physics · Physics 2021-11-17 Zeljko Kereta , Robert Twyman , Simon Arridge , Kris Thielemans , Bangti Jin