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Digital pathology involves converting physical tissue slides into high-resolution Whole Slide Images (WSIs), which pathologists analyze for disease-affected tissues. However, large histology slides with numerous microscopic fields pose…

Image and Video Processing · Electrical Eng. & Systems 2024-02-19 Mobina Mansoori , Sajjad Shahabodini , Jamshid Abouei , Arash Mohammadi , Konstantinos N. Plataniotis

The classification of gigapixel histopathology images with deep multiple instance learning models has become a critical task in digital pathology and precision medicine. In this work, we propose a Transformer-based multiple instance…

Computer Vision and Pattern Recognition · Computer Science 2023-11-21 Josef Cersovsky , Sadegh Mohammadi , Dagmar Kainmueller , Johannes Hoehne

This paper presents a new approach for classifying 2D histopathology patches using few-shot learning. The method is designed to tackle a significant challenge in histopathology, which is the limited availability of labeled data. By applying…

Image and Video Processing · Electrical Eng. & Systems 2024-03-12 Aymen Sadraoui , Ségolène Martin , Eliott Barbot , Astrid Laurent-Bellue , Jean-Christophe Pesquet , Catherine Guettier , Ismail Ben Ayed

Whole Slide Images (WSIs) play a crucial role in accurate cancer diagnosis and prognosis, as they provide tissue details at the cellular level. However, the rapid growth of computational tasks involving WSIs poses significant challenges.…

Computer Vision and Pattern Recognition · Computer Science 2025-10-30 Doanh C. Bui , Hoai Luan Pham , Vu Trung Duong Le , Tuan Hai Vu , Van Duy Tran , Khang Nguyen , Yasuhiko Nakashima

Histopathology whole slide images (WSIs) can reveal significant inter-hospital variability such as illumination, color or optical artifacts. These variations, caused by the use of different scanning protocols across medical centers…

Computer Vision and Pattern Recognition · Computer Science 2022-07-01 Marin Scalbert , Maria Vakalopoulou , Florent Couzinié-Devy

Computational Pathology (CPATH) systems have the potential to automate diagnostic tasks. However, the artifacts on the digitized histological glass slides, known as Whole Slide Images (WSIs), may hamper the overall performance of CPATH…

Computer Vision and Pattern Recognition · Computer Science 2023-05-30 Neel Kanwal , Trygve Eftestol , Farbod Khoraminia , Tahlita CM Zuiverloon , Kjersti Engan

Digital whole slide images (WSIs) are generally captured at microscopic resolution and encompass extensive spatial data. Directly feeding these images to deep learning models is computationally intractable due to memory constraints, while…

Image and Video Processing · Electrical Eng. & Systems 2024-11-22 Manahil Raza , Ruqayya Awan , Raja Muhammad Saad Bashir , Talha Qaiser , Nasir M. Rajpoot

Whole slide images, with their gigapixel-scale panoramas of tissue samples, are pivotal for precise disease diagnosis. However, their analysis is hindered by immense data size and scarce annotations. Existing MIL methods face challenges due…

Computer Vision and Pattern Recognition · Computer Science 2026-02-26 Weiyi Wu , Xinwen Xu , Chongyang Gao , Xingjian Diao , Siting Li , Jiang Gui

The rapidly emerging field of deep learning-based computational pathology has shown promising results in utilizing whole slide images (WSIs) to objectively prognosticate cancer patients. However, most prognostic methods are currently…

Computer Vision and Pattern Recognition · Computer Science 2023-11-21 Mingxin Liu , Yunzan Liu , Hui Cui , Chunquan Li , Jiquan Ma

Automated generation of diagnostic pathology reports directly from whole slide images (WSIs) is an emerging direction in computational pathology. Translating high-resolution tissue patterns into clinically coherent text remains difficult…

Computer Vision and Pattern Recognition · Computer Science 2025-12-16 Noorul Wahab , Nasir Rajpoot

With the development of computational pathology, deep learning methods for Gleason grading through whole slide images (WSIs) have excellent prospects. Since the size of WSIs is extremely large, the image label usually contains only…

Computer Vision and Pattern Recognition · Computer Science 2022-06-28 Hao Bian , Zhuchen Shao , Yang Chen , Yifeng Wang , Haoqian Wang , Jian Zhang , Yongbing Zhang

Considering the profound transformation affecting pathology practice, we aimed to develop a scalable artificial intelligence (AI) system to diagnose colorectal cancer from whole-slide images (WSI). For this, we propose a deep learning (DL)…

In recent years, histopathological whole slide image (WSI)- based survival analysis has attracted much attention in medical image analysis. In practice, WSIs usually come from different hospitals or laboratories, which can be seen as…

Computer Vision and Pattern Recognition · Computer Science 2024-11-22 Yuntao Shou , Peiqiang Yan , Xingjian Yuan , Xiangyong Cao , Qian Zhao , Deyu Meng

Cancer remains one of the leading causes of mortality worldwide, necessitating accurate diagnosis and prognosis. Whole Slide Imaging (WSI) has become an integral part of clinical workflows with advancements in digital pathology. While…

Image and Video Processing · Electrical Eng. & Systems 2025-04-09 Ahmad Hussein , Mukesh Prasad , Ali Anaissi , Ali Braytee

Accurate diagnosis of disease often depends on the exhaustive examination of Whole Slide Images (WSI) at microscopic resolution. Efficient handling of these data-intensive images requires lossy compression techniques. This paper…

Deep learning has become the mainstream methodological choice for analyzing and interpreting whole-slide digital pathology images (WSIs). It is commonly assumed that tumor regions carry most predictive information. In this paper, we…

Quantitative Methods · Quantitative Biology 2022-04-26 Zihan Chen , Xingyu Li , Miaomiao Yang , Hong Zhang , Xu Steven Xu

Whole Slide Images (WSIs) in digital pathology are used to diagnose cancer subtypes. The difference in procedures to acquire WSIs at various trial sites gives rise to variability in the histopathology images, thus making consistent…

Image and Video Processing · Electrical Eng. & Systems 2022-04-07 Milad Sikaroudi , Shahryar Rahnamayan , H. R. Tizhoosh

Multiple Instance Learning (MIL) is widely used in analyzing histopathological Whole Slide Images (WSIs). However, existing MIL methods do not explicitly model the data distribution, and instead they only learn a bag-level or instance-level…

Computer Vision and Pattern Recognition · Computer Science 2022-06-20 Linhao Qu , Xiaoyuan Luo , Shaolei Liu , Manning Wang , Zhijian Song

Digital histopathology whole slide images (WSIs) provide gigapixel-scale high-resolution images that are highly useful for disease diagnosis. However, digital histopathology image analysis faces significant challenges due to the limited…

Computer Vision and Pattern Recognition · Computer Science 2026-02-13 Bodong Zhang , Xiwen Li , Hamid Manoochehri , Xiaoya Tang , Deepika Sirohi , Beatrice S. Knudsen , Tolga Tasdizen

Whole slide image (WSI) processing is becoming part of the key components of standard clinical diagnosis for various diseases. However, the direct application of conventional image processing algorithms to WSI faces certain obstacles…

Computer Vision and Pattern Recognition · Computer Science 2023-09-18 Yuanfeng Wu , Shaojie Li , Zhiqiang Du , Wentao Zhu