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Deep neural networks often suffer performance drops when test data distribution differs from training data. Domain Generalization (DG) aims to address this by focusing on domain-invariant features or augmenting data for greater diversity.…

Computer Vision and Pattern Recognition · Computer Science 2025-09-09 Nam Duong Tran , Nam Nguyen Phuong , Hieu H. Pham , Phi Le Nguyen , My T. Thai

Deep learning models usually suffer from domain shift issues, where models trained on one source domain do not generalize well to other unseen domains. In this work, we investigate the single-source domain generalization problem: training a…

Computer Vision and Pattern Recognition · Computer Science 2023-04-24 Cheng Ouyang , Chen Chen , Surui Li , Zeju Li , Chen Qin , Wenjia Bai , Daniel Rueckert

Image alignment across domains has recently become one of the realistic and popular topics in the research community. In this problem, a deep learning-based image alignment method is usually trained on an available largescale database.…

Computer Vision and Pattern Recognition · Computer Science 2019-06-03 Thanh-Dat Truong , Khoa Luu , Chi Nhan Duong , Ngan Le , Minh-Triet Tran

We present MaskGen, a theoretically grounded and deliberately simple approach for domain generalization in 3D biomedical image segmentation. Modern segmentation models degrade sharply under shifts in modality, disease severity, clinical…

Image and Video Processing · Electrical Eng. & Systems 2026-05-12 Sebo Diaz , Polina Golland , Elfar Adalsteinsson , Neel Dey

Deep learning-based models in medical imaging often struggle to generalize effectively to new scans due to data heterogeneity arising from differences in hardware, acquisition parameters, population, and artifacts. This limitation presents…

Image and Video Processing · Electrical Eng. & Systems 2023-08-09 Sebastian Nørgaard Llambias , Mads Nielsen , Mostafa Mehdipour Ghazi

In medical imaging, the heterogeneity of multi-centre data impedes the applicability of deep learning-based methods and results in significant performance degradation when applying models in an unseen data domain, e.g. a new centreor a new…

Computer Vision and Pattern Recognition · Computer Science 2020-08-12 Hongwei Li , Timo Loehr , Anjany Sekuboyina , Jianguo Zhang , Benedikt Wiestler , Bjoern Menze

Unsupervised Domain Adaptation (UDA) and domain generalization (DG) are two research areas that aim to tackle the lack of generalization of Deep Neural Networks (DNNs) towards unseen domains. While UDA methods have access to unlabeled…

Computer Vision and Pattern Recognition · Computer Science 2023-04-25 Manuel Schwonberg , Fadoua El Bouazati , Nico M. Schmidt , Hanno Gottschalk

Deep learning models perform best when tested on target (test) data domains whose distribution is similar to the set of source (train) domains. However, model generalization can be hindered when there is significant difference in the…

Computer Vision and Pattern Recognition · Computer Science 2020-08-19 Pulkit Khandelwal , Paul Yushkevich

Single-source domain generalization (SDG) in medical image segmentation is a challenging yet essential task as domain shifts are quite common among clinical image datasets. Previous attempts most conduct global-only/random augmentation.…

Computer Vision and Pattern Recognition · Computer Science 2022-11-29 Zixian Su , Kai Yao , Xi Yang , Qiufeng Wang , Jie Sun , Kaizhu Huang

Machine learning algorithms have revolutionized different fields, including natural language processing, computer vision, signal processing, and medical data processing. Despite the excellent capabilities of machine learning algorithms in…

Image and Video Processing · Electrical Eng. & Systems 2022-12-07 Gita Sarafraz , Armin Behnamnia , Mehran Hosseinzadeh , Ali Balapour , Amin Meghrazi , Hamid R. Rabiee

In real-life applications, machine learning models often face scenarios where there is a change in data distribution between training and test domains. When the aim is to make predictions on distributions different from those seen at…

Machine Learning · Computer Science 2021-11-04 Lucas Mansilla , Rodrigo Echeveste , Diego H. Milone , Enzo Ferrante

The absence of well-structured large datasets in medical computer vision results in decreased performance of automated systems and, especially, of deep learning models. Domain generalization techniques aim to approach unknown domains from a…

Image and Video Processing · Electrical Eng. & Systems 2024-06-04 Nikolaos Spanos , Anastasios Arsenos , Paraskevi-Antonia Theofilou , Paraskevi Tzouveli , Athanasios Voulodimos , Stefanos Kollias

Medical images are usually collected from multiple domains, leading to domain shifts that impair the performance of medical image segmentation models. Domain Generalization (DG) aims to address this issue by training a robust model with…

Image and Video Processing · Electrical Eng. & Systems 2025-06-13 Xi Chen , Zhiqiang Shen , Peng Cao , Jinzhu Yang , Osmar R. Zaiane

Medical image segmentation plays a crucial role in clinical workflows, but domain shift often leads to performance degradation when models are applied to unseen clinical domains. This challenge arises due to variations in imaging…

Computer Vision and Pattern Recognition · Computer Science 2025-08-01 Yingkai Wang , Yaoyao Zhu , Xiuding Cai , Yuhao Xiao , Haotian Wu , Yu Yao

Model generalization capacity at domain shift (e.g., various imaging protocols and scanners) is crucial for deep learning methods in real-world clinical deployment. This paper tackles the challenging problem of domain generalization, i.e.,…

Computer Vision and Pattern Recognition · Computer Science 2020-07-07 Quande Liu , Qi Dou , Pheng-Ann Heng

Deep learning-based medical image segmentation faces significant challenges arising from limited labeled data and domain shifts. While prior approaches have primarily addressed these issues independently, their simultaneous occurrence is…

Computer Vision and Pattern Recognition · Computer Science 2025-06-30 Zanting Ye , Ke Wang , Wenbing Lv , Qianjin Feng , Lijun Lu

Recently, we have witnessed great progress in the field of medical imaging classification by adopting deep neural networks. However, the recent advanced models still require accessing sufficiently large and representative datasets for…

Computer Vision and Pattern Recognition · Computer Science 2020-10-30 Haoliang Li , YuFei Wang , Renjie Wan , Shiqi Wang , Tie-Qiang Li , Alex C. Kot

The insertion of deep learning in medical image analysis had lead to the development of state-of-the art strategies in several applications such a disease classification, as well as abnormality detection and segmentation. However, even the…

Image and Video Processing · Electrical Eng. & Systems 2022-02-24 Mauricio Orbes-Arteaga , Thomas Varsavsky , Lauge Sorensen , Mads Nielsen , Akshay Pai , Sebastien Ourselin , Marc Modat , M Jorge Cardoso

For medical image analysis, segmentation models trained on one or several domains lack generalization ability to unseen domains due to discrepancies between different data acquisition policies. We argue that the degeneration in segmentation…

Computer Vision and Pattern Recognition · Computer Science 2022-08-09 Ziqi Zhou , Lei Qi , Yinghuan Shi

Medical imaging datasets usually exhibit domain shift due to the variations of scanner vendors, imaging protocols, etc. This raises the concern about the generalization capacity of machine learning models. Domain generalization (DG), which…

Computer Vision and Pattern Recognition · Computer Science 2021-06-15 Chenxin Li , Qi Qi , Xinghao Ding , Yue Huang , Dong Liang , Yizhou Yu
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