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Cytoplasmic streaming, the coherent flow of cytoplasm, plays a critical role in transport and mixing over large scales in eukaryotic cells. In many large cells, this process is driven by active forces at the cell boundary, such as cortical…

Biological Physics · Physics 2025-02-18 Pyae Hein Htet , Eric Lauga

Many cells exhibit large-scale active circulation of their entire fluid contents, a process termed cytoplasmic streaming. This phenomenon is particularly prevalent in plant cells, often presenting strikingly regimented flow patterns. The…

Soft Condensed Matter · Physics 2013-08-30 Francis G. Woodhouse , Raymond E. Goldstein

Large scale motion of cytoplasm called cytoplasmic streaming occurs in some large eukaryotic cells to stir the cell's constituents. In Drosophila oocytes, microtubules have been observed to undergo undulating motion, curving to form…

Subcellular Processes · Quantitative Biology 2012-07-11 J. M. Deutsch , M. E. Brunner , William M. Saxton

Cytoplasmic streaming, the persistent flow of fluid inside a cell, induces intracellular transport, which plays a key role in fundamental biological processes. In meiosis II mouse oocytes (developing egg cells) awaiting fertilisation, the…

Biological Physics · Physics 2024-10-18 Weida Liao , Eric Lauga

Undulatory locomotion of microorganisms like soil-dwelling worms and spermatozoa, in structured environments, is ubiquitous in nature. They navigate complex environments consisting of fluids and obstacles, negotiating hydrodynamic effects…

Fluid Dynamics · Physics 2010-10-20 Trushant S. Majmudar , Eric Keaveny , Mike Shelley , Jun Zhang

Caenorhabditis elegans, a free-living soil nematode, propels itself by producing undulatory body motion and displays a rich variety of body shapes and trajectories during its locomotion in complex environments. Here we show that the complex…

We experimentally studied the locomotion of the nematode C. elegans in both fluidic and granular media. In this fluid dynamics video, we show the motility gaits of the nematode in these two environments. The motility of the nematode C.…

Fluid Dynamics · Physics 2011-10-17 X. N. Shen , G. Juarez , P. E. Arratia

Many microorganisms live and evolve in complex fluids. Examples include mammalian spermatozoa in cervical mucus, worms (e.g., \textit{C. elegans}) in wet soil, and bacteria (e.g., \textit{H. pylori}) in our stomach lining. Due to the…

Fluid Dynamics · Physics 2022-10-21 Paulo E. Arratia

Gastrulation, namely cell internalization, is a significant milestone during the development of metazoans from worm to human, which generates multiple embryonic layers with distinct cell fates and spatial organizations. Although many…

Cell Behavior · Quantitative Biology 2022-01-17 Jiao Miao , Guoye Guan , Chao Tang

In aquatic plants such as the Characean algae, the force generation that drives cyclosis is localized within the cytoplasm, yet produces fluid flows throughout the vacuole. For this to occur the tonoplast must transmit hydrodynamic shear…

Biological Physics · Physics 2015-05-13 Jan-Willem van de Meent , Andy J. Sederman , Lynn F. Gladden , Raymond E. Goldstein

We present a computer simulation study, via lattice Boltzmann simulations, of a microscopic model for cytoplasmic streaming in algal cells such as those of Chara corallina. We modelled myosin motors tracking along actin lanes as spheres…

Biological Physics · Physics 2013-03-01 K. Wolff , D. Marenduzzo , M. E. Cates

In the cellular phenomena of cytoplasmic streaming, molecular motors carrying cargo along a network of microtubules entrain the surrounding fluid. The piconewton forces produced by individual motors are sufficient to deform long…

Soft Condensed Matter · Physics 2021-01-20 David B. Stein , Gabriele De Canio , Eric Lauga , Michael J. Shelley , Raymond E. Goldstein

The pharynx of the nematode Caenorhabditis elegans is a neuromuscular pump that exhibits two typical motions: pumping and peristalsis. While the dynamics of these motions are well characterized, the underlying mechanisms generating most of…

Neurons and Cognition · Quantitative Biology 2019-03-29 Dana Sherman , David Harel

Large cells often rely on cytoplasmic flows for intracellular transport, maintaining homeostasis, and positioning cellular components. Understanding the mechanisms of these flows is essential for gaining insights into cell function,…

Fluid Dynamics · Physics 2023-11-09 Brato Chakrabarti , Stanislav Y. Shvartsman , Michael J. Shelley

The infection pathway of virus in cytoplasm of a living cell is studied from the viewpoint of diffusion theory. The cytoplasm plays a role of a medium for stochastic motion of the virus contained in the endosome as well as the free virus.…

Biological Physics · Physics 2010-03-04 Yuichi Itto

The proper positioning of the mitotic spindle is crucial for asymmetric cell division and generating cell diversity during development. Proper position in the single-cell embryo of Caenorhabditis elegans is achieved initially by the…

Biological Physics · Physics 2015-11-10 Ehssan Nazockdast , Abtin Rahimian , Daniel Needleman , Michael Shelley

The millimeter-long soil-dwelling nematode {\it C. elegans} propels itself by producing undulations that propagate along its body and turns by assuming highly curved shapes. According to our recent study [PLoS ONE \textbf{7}, e40121 (2012)]…

Fluid Dynamics · Physics 2019-01-18 Alejandro Bilbao , Eligiusz Wajnryb , Siva Vanapalli , Jerzy Blawzdziewicz

The video showcases how C. elegans worms respond to DC and AC electrical stimulations. Gabel et al (2007) demonstrated that in the presence of DC and low frequency AC fields, worms of stage L2 and larger propel themselves towards the…

Fluid Dynamics · Physics 2015-05-20 Han-Sheng Chuang , David Raizen , Nooreen Dabbish , Haim Bau

Despite the relative simplicity of C. elegans, its locomotion machinery is not yet well understood. We focus on the generation of dorsoventral body bends. While central pattern generators are commonly involved in animal locomotion, their…

Neurons and Cognition · Quantitative Biology 2017-11-08 Erick Olivares , Eduardo J. Izquierdo , Randall D. Beer

The physical and bio-mechanical principles that govern undulatory movement on wet surfaces have important applications in physiology, physics, and engineering. The nematode {\it C. elegans}, with its highly stereotypical and functionally…

Fluid Dynamics · Physics 2015-06-03 Xiao N. Shen , J. Sznitman , P. Krajacic , T. Lamitina , P. E. Arratia
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