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Protein function is inherently linked to its localization within the cell, and fluorescent microscopy data is an indispensable resource for learning representations of proteins. Despite major developments in molecular representation…

Quantitative Methods · Quantitative Biology 2022-05-25 Anastasia Razdaibiedina , Alexander Brechalov

Optical imaging relies on the ability to illuminate an object, collect and analyze the light it scatters or transmits. Propagation through complex media such as biological tissues was so far believed to degrade the attainable depth as well…

Optics · Physics 2010-09-24 S. M. Popoff , G. Lerosey , M. Fink , A. C. Boccara , S. Gigan

High resolution optical microscopy is essential in neuroscience but suffers from scattering in biological tissues. It therefore grants access to superficial layers only. Recently developed techniques use scattered photons for imaging by…

Scattering obscures information carried by wave by producing a speckle pattern, posing a common challenge across various fields, including microscopy and astronomy. Traditional methods for extracting information from speckles often rely on…

Many optical measurement techniques, such as light scattering from wavelength-scale particles or detecting motion from a surface with an optical lever, encode information in a complex radiation pattern. Extracting all available information…

Quantum Physics · Physics 2025-12-22 Youssef Tawfik , Shan Hao , Thomas P. Purdy

Scattering, especially multiple scattering, is a well known problem in imaging, ranging from astronomy to medicine. In particular it is often desirable to be able to perform non-invasive imaging through turbid and/or opaque media. Many…

Optics · Physics 2024-04-23 Harry Penketh , Jacopo Bertolotti

Inverse scattering aims to infer information about a hidden object by using the received scattered waves and training data collected from forward mathematical models. Recent advances in computing have led to increasing attention towards…

Applications · Statistics 2023-05-03 Chih-Li Sung , Yao Song , Ying Hung

Fluorescence microscopy has revolutionized biomedical research over the past three decades. Its high molecular specificity and unrivaled single molecule level sensitivity have enabled breakthroughs in a variety of research fields. For in…

Optics · Physics 2012-03-21 Meng Cui , Ke Si , Reto Fiolka

Much of the information processing performed by a neuron occurs in the dendritic tree. For neural systems using light for communication, it is advantageous to convert signals to the electronic domain at synaptic terminals so dendritic…

Neural and Evolutionary Computing · Computer Science 2019-04-08 Jeffrey M. Shainline

Every day, the human brain processes an immense volume of visual information, relying on intricate neural mechanisms to perceive and interpret these stimuli. Recent breakthroughs in functional magnetic resonance imaging (fMRI) have enabled…

Computer Vision and Pattern Recognition · Computer Science 2023-05-22 Matteo Ferrante , Furkan Ozcelik , Tommaso Boccato , Rufin VanRullen , Nicola Toschi

Multiple scattering of waves in disordered media is a nightmare whether it be for detection or imaging purposes. The best approach so far to get rid of multiple scattering is optical coherence tomography. It basically combines confocal…

We can better understand deep neural networks by identifying which features each of their neurons have learned to detect. To do so, researchers have created Deep Visualization techniques including activation maximization, which…

Neural and Evolutionary Computing · Computer Science 2016-05-10 Anh Nguyen , Jason Yosinski , Jeff Clune

The brain is organized in a modular way, serving multiple functionalities. This multiplicity requires that both positive (e.g. excitatory, phase-coherent) and negative (e.g. inhibitory, phase-opposing) interactions take place across brain…

Neurons and Cognition · Quantitative Biology 2019-07-29 Assaf Almog , Ori Roethler , Renate Buijink , Stephan Michel , Johanna H Meijer , Jos H. T. Rohling , Diego Garlaschelli

Fluorescence microscopy is widely used in biological imaging, however scattering from tissues strongly limits its applicability to a shallow depth. In this work we adapt a methodology inspired from stellar speckle interferometry, and…

Neural networks are widely adopted to solve complex and challenging tasks. Especially in high-stakes decision-making, understanding their reasoning process is crucial, yet proves challenging for modern deep networks. Feature visualization…

Computer Vision and Pattern Recognition · Computer Science 2026-02-18 Ada Gorgun , Bernt Schiele , Jonas Fischer

Extending super-resolution imaging techniques to objects hidden in strongly scattering media potentially revolutionize the technical analysis for much broader categories of samples, such as biological tissues. The main challenge is the…

Confocal and multi-photon microscopy are widely used for in-vivo fluorescence imaging of biological tissues such as the brain, offering non-invasive access up to ~1 mm depth without major loss in performance. A recently-developed…

Fluorescent Neuronal Cells v2 is a collection of fluorescence microscopy images and the corresponding ground-truth annotations, designed to foster innovative research in the domains of Life Sciences and Deep Learning. This dataset…

Despite their increasing popularity and success in a variety of supervised learning problems, deep neural networks are extremely hard to interpret and debug: Given and already trained Deep Neural Net, and a set of test inputs, how can we…

Machine Learning · Computer Science 2018-06-07 Uday Singh Saini , Evangelos E. Papalexakis

`Bursting', defined as periods of high frequency firing of a neuron separated by periods of quiescence, has been observed in various neuronal systems, both \textit{in vitro} and \textit{in vivo}. It has been associated with a range of…

Neurons and Cognition · Quantitative Biology 2018-06-20 E. Cotterill , S. J. Eglen