Related papers: Quantifying allowable motion to achieve safe dose …

Objective: Quantify geometric and dosimetric accuracy of a novel prostate MR-to-MR deformable image registration (DIR) approach to support MR-guided adaptive radiation therapy dose accumulation. Approach: We evaluated DIR accuracy in 25…

Prostate cancer is one of the most common types of cancer in men. Its diagnosis by biopsy requires a high level of expertise and precision from the surgeon, so the results are highly operator-dependent. The aim of this work is to develop a…

To improve the quality of cancer treatment with protons, a translation of X-ray Computed Tomography (CT) images into a map of the proton stopping powers needs to be more accurate. Proton stopping powers determined from CT images have…

Ultraportable X-ray devices are ideal for TB screening in resource-limited settings. Unfortunately, guidelines on the radiation safety of these devices are lacking. The aim of the study was to determine the radiation dose by scattered and…

Soft robotic instruments could navigate delicate, tortuous anatomy more safely than rigid tools, but clinical adoption is limited by insufficient tip functionalization and real-time feedback at the tissue interface. Few sensing and…

With new advancements in technology, it is now possible to collect data for a variety of different metrics describing tumor growth, including tumor volume, composition, and vascularity, among others. For any proposed model of tumor growth…

Cone beam CT (CBCT) has been widely used for patient setup in image guided radiation therapy (IGRT). Radiation dose from CBCT scans has become a clinical concern. The purposes of this study are 1) to commission a GPU-based Monte Carlo (MC)…

Conventional cancer therapies include surgery, radiation therapy, chemotherapy, and, more recently, immunotherapy. These modalities are often combined to improve the therapeutic index. The general concept of radiation therapy is to increase…

Purpose: In this modelling study we pursued two main goals. The first was to establish a new CTV-to-PTV expansion which considers the closest and most critical organ at risk (OAR). The second goal was to investigate the impact of the…

Fiducial marker positions in projection image of cone-beam computed tomography (CBCT) scans have been studied to evaluate daily residual motion during breath-hold radiation therapy. Fiducial marker migration posed challenges in accurately…

A survey was designed to inquire about the practice of proton SBRT treatment for prostate cancer. The survey was distributed to all 30 proton therapy centers in the United States that participate in the National Clinical Trial Network in…

The purpose of this study was to use various dosimetrical indices to determine the best IMRT modality technique for treating patients with prostate cancer. Ten patients with prostate cancer were included in this study. Intensity modulated…

Adaptive Radiotherapy (ART) is an emerging technique for treating cancer patients which facilitates higher delivery accuracy and has the potential to reduce toxicity. However, ART is also resource-intensive, requiring extra human and…

Diffusing alpha-emitters Radiation Therapy ("Alpha DaRT") is a new treatment modality focusing on the use of alpha particles against solid tumors. The introduction of Alpha DaRT in clinical settings calls for the development of detailed…

Purpose: Historically, spot scanning proton therapy (SSPT) treatment planning utilizes dose volume constraints and linear-energy-transfer (LET) volume constraints separately to balance tumor control and organs-at-risk (OARs) protection. We…

Stereotactic radiotherapy (SRT) is one of the most important treatment for patients with brain metastases (BM). Conventionally, following SRT patients are monitored by serial imaging and receive salvage treatments in case of significant…

Prediction of survivability in a patient for tumor progression is useful to estimate the effectiveness of a treatment protocol. In our work, we present a model to take into account the heterogeneous nature of a tumor to predict survival.…

Radiotherapy is one of the main methods in the successful treatment of cancer. The tumor is irradiated with photons or charged particles (e.g. protons), and in the case of massive charged particles, the treatment results in less unnecessary…

Background: Promising results for mammary carcinoma treatment with photodynamic therapy (PDT) presuppose a careful selection of irradiation light wavelength. Methods: 4T1 tumors implanted in NOD-SCID mice were treated with Metvix-PDT under…

Spatially Fractionated Radiation Therapy (SFRT) produces highly heterogeneous dose distributions, for which conventional metrics such as peak, valley, or average dose can yield ambiguous or inconsistent estimates of therapeutic window…