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Living systems operate far from thermodynamic equilibrium. Enzymatic activity can induce broken detailed balance at the molecular scale. This molecular scale breaking of detailed balance is crucial to achieve biological functions such as…

Biological Physics · Physics 2018-05-02 F. Gnesotto , F. Mura , J. Gladrow , C. P. Broedersz

Measuring and quantifying non-equilibrium dynamics in active biological systems is a major challenge, because of their intrinsic stochastic nature and the limited number of variables accessible in any real experiment. We investigate what…

Biological Physics · Physics 2018-07-25 Federica Mura , Grzegorz Gradziuk , Chase P. Broedersz

Detecting and quantifying non-equilibrium activity is essential for studying internally driven assemblies, including synthetic active matter and complex living systems such as cells or tissue. We discuss a non-invasive approach of measuring…

Biological Physics · Physics 2019-05-22 Grzegorz Gradziuk , Federica Mura , Chase P. Broedersz

Time-lapse microscopy imaging provides direct access to the dynamics of soft and living systems. At mesoscopic scales, such microscopy experiments reveal intrinsic fluctuations, which may have both thermal and non-equilibrium origins. These…

Biological Physics · Physics 2020-12-02 F. S. Gnesotto , G. Gradziuk , P. Ronceray , C. P. Broedersz

Equilibrium statistical mechanics provides a robust framework for characterizing phase transitions in systems whose microsopic dynamics are time-reversible. Efforts to develop and validate theoretical frameworks for time-irreversible,…

Soft Condensed Matter · Physics 2025-12-18 Stuart J. Thomson , Jack-William Barotta , Daniel M. Harris

Active dynamic processes of cells are largely driven by the cytoskeleton, a complex and adaptable semiflexible polymer network, motorized by mechanoenzymes. Small dimensions, confined geome- tries and hierarchical structures make it…

Biological Physics · Physics 2017-08-23 Jannes Gladrow , Chase P. Broedersz , Christoph F. Schmidt

Complex fluids subjected to localized microscopic energy inputs, typical of active microrheology setups, exhibit poorly understood nonequilibrium behaviors because of the intricate self-organization of their mesoscopic constituents. In this…

Statistical Mechanics · Physics 2025-12-15 Danilo Forastiere , Emanuele Locatelli , Gianmaria Falasco , Enzo Orlandini , Marco Baiesi

Many living and artificial systems show a similar emergent behavior and collective motions on different scales, starting from swarms of bacteria to synthetic active particles, herds of mammals and crowds of people. What all these systems…

Soft Condensed Matter · Physics 2024-01-01 Bohdan Senyuk , Jin-Sheng Wua , Ivan I. Smalyukh

By systematically varying the mobility of self-propelled particles in a two-dimensional (2D) lattice, we experimentally study the influence of particle mobility on system's collective motion. Our system is intrinsically non-equilibrium due…

Soft Condensed Matter · Physics 2016-02-19 Hongchuan Shen , Peng Tan , Lei Xu

We investigate proteins within heterogeneous cell membranes where non-equilibrium phenomena arises from spatial variations in concentration and temperature. We develop simulation methods building on non-equilibrium statistical mechanics to…

Soft Condensed Matter · Physics 2025-08-28 D. Jasuja , P. J. Atzberger

We set up a mesoscopic theory for interacting Brownian particles embedded in a nonequilibrium environment, starting from the microscopic interacting many-body theory. Using nonequilibrium linear response theory, we characterize the…

Statistical Mechanics · Physics 2017-01-04 Stefano Steffenoni , Klaus Kroy , Gianmaria Falasco

Because of consuming energy to drive their motion, systems of active colloids are intrinsically out of equilibrium. In the past decade, a variety of intriguing dynamic patterns have been observed in systems of active colloids, and they…

Soft Condensed Matter · Physics 2020-04-16 Zhan Ma , Mingcheng Yang , Ran Ni

Measurement and feedback control of stochastic dynamics has been actively studied for not only stabilizing the system but also for generating additional entropy flows originating in the information flow in the feedback controller. In…

Mesoscale and Nanoscale Physics · Physics 2021-08-11 Motoki Asano , Takuma Aihara , Tai Tsuchizawa , Hiroshi Yamaguchi

Biological activity gives rise to non-equilibrium fluctuations in the cytoplasm of cells; however, there are few methods to directly measure these fluctuations. Using a reconstituted actin cytoskeleton, we show that the bending dynamics of…

Soft Condensed Matter · Physics 2009-11-13 C. P. Brangwynne , G. H. Koenderink , F. C. MacKintosh , D. A. Weitz

Living organisms are inherently out-of-equilibrium systems. We employ new developments in stochastic energetics and rely on a minimal microscopic model to predict the amount of mechanical energy dissipated by such dynamics. Our model…

The requirements pertaining to the reliability and accuracy of micro-electromechanical gyroscopic sensors are increasing,as systems for vehicle localization emerge as an enabling factor for autonomous driving. Since micro-electromechanical…

Applied Physics · Physics 2020-02-07 Ulrike Nabholz , Michael Curcic , Jan E. Mehner , Peter Degenfeld-Schonburg

In thermodynamic equilibrium, the fluctuation-dissipation theorem links thermal fluctuations and dissipation. Biological systems, however, are driven out of equilibrium by internal processes that produce additional, active fluctuations.…

Soft Condensed Matter · Physics 2026-01-29 Ashot Matevosyan , Frank Jülicher , Ricard Alert

We review the depinning and nonequilibrium phases of collectively interacting particle systems driven over random or periodic substrates. This type of system is relevant to vortices in type-II superconductors, sliding charge density waves,…

Superconductivity · Physics 2017-12-06 C. Reichhardt , C. J. Olson Reichhardt

In equilibrium, the physical properties of matter are set by the interactions between the constituents. In contrast, the energy input of the individual components controls the behavior of synthetic or living active matter. Great progress…

Soft Condensed Matter · Physics 2025-08-29 Q. Martinet , Y. Li , A. Aubret , E. Hannezo , J. Palacci

We show that active transport processes in biological systems can be understood through a local equilibrium description formulated at the mesoscale, the scale to describe stochastic processes. This new approach uses the method established…

Soft Condensed Matter · Physics 2007-05-23 S. Kjelstrup , J. M. Rubi , D. Bedeaux
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