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Given the complex geometry of white matter streamlines, Autoencoders have been proposed as a dimension-reduction tool to simplify the analysis streamlines in a low-dimensional latent spaces. However, despite these recent successes, the…

Machine Learning · Statistics 2023-11-21 Andrew Lizarraga , Brandon Taraku , Edouardo Honig , Ying Nian Wu , Shantanu H. Joshi

The Variational Autoencoder (VAE) is a powerful deep generative model that is now extensively used to represent high-dimensional complex data via a low-dimensional latent space learned in an unsupervised manner. In the original VAE model,…

Sound · Computer Science 2021-06-15 Xiaoyu Bie , Laurent Girin , Simon Leglaive , Thomas Hueber , Xavier Alameda-Pineda

We propose a combination of a variational autoencoder and a transformer based model which fully utilises graph convolutional and graph pooling layers to operate directly on graphs. The transformer model implements a novel node encoding…

Machine Learning · Computer Science 2021-04-12 Joshua Mitton , Hans M. Senn , Klaas Wynne , Roderick Murray-Smith

The de novo design of drug molecules is recognized as a time-consuming and costly process, and computational approaches have been applied in each stage of the drug discovery pipeline. Variational autoencoder is one of the computer-aided…

Quantum Physics · Physics 2021-12-24 Junde Li , Swaroop Ghosh

In this thesis, we develop methods to enhance the interpretability of recent representation learning techniques in natural language processing (NLP) while accounting for the unavailability of annotated data. We choose to leverage…

Computation and Language · Computer Science 2023-05-05 Ghazi Felhi

The simplified molecular-input line-entry system (SMILES) is the most popular representation of chemical compounds. Therefore, many SMILES-based molecular property prediction models have been developed. In particular, transformer-based…

Quantitative Methods · Quantitative Biology 2022-05-03 Ingoo Lee , Hojung Nam

Physical imaging is a foundational characterization method in areas from condensed matter physics and chemistry to astronomy and spans length scales from atomic to universe. Images encapsulate crucial data regarding atomic bonding,…

Variational Autoencoders (VAEs) are powerful generative models capable of learning compact latent representations. However, conventional VAEs often generate relatively blurry images due to their assumption of an isotropic Gaussian latent…

Computer Vision and Pattern Recognition · Computer Science 2025-04-21 Andrew Kiruluta

Variational autoencoders (VAEs) have ushered in a new era of unsupervised learning methods for complex distributions. Although these techniques are elegant in their approach, they are typically not useful for representation learning. In…

Machine Learning · Computer Science 2020-01-10 Ali Lotfi Rezaabad , Sriram Vishwanath

Learning interpretable representations of data remains a central challenge in deep learning. When training a deep generative model, the observed data are often associated with certain categorical labels, and, in parallel with learning to…

Machine Learning · Computer Science 2019-10-01 Yifan Xue , Michael Ding , Xinghua Lu

Molecular Representation Learning is essential to solving many drug discovery and computational chemistry problems. It is a challenging problem due to the complex structure of molecules and the vast chemical space. Graph representations of…

Machine Learning · Computer Science 2023-01-18 Atia Hamidizadeh , Tony Shen , Martin Ester

The Variational Autoencoder (VAE) is a powerful architecture capable of representation learning and generative modeling. When it comes to learning interpretable (disentangled) representations, VAE and its variants show unparalleled…

Machine Learning · Computer Science 2019-04-17 Michal Rolinek , Dominik Zietlow , Georg Martius

Extracting compact, physically interpretable representations from high-dimensional scientific data is a persistent challenge due to the complex, nonlinear structures inherent in physical systems. We propose a Gaussian Mixture Variational…

Machine Learning · Computer Science 2025-12-01 Tiffany Fan , Murray Cutforth , Marta D'Elia , Alexandre Cortiella , Alireza Doostan , Eric Darve

Variational autoencoders (VAEs) are among leading approaches to address the problem of learning disentangled representations. Typically a single VAE is used and disentangled representations are sought within its single continuous latent…

Machine Learning · Statistics 2026-04-02 Veranika Boukun , Jörg Lücke

Self-supervised learning (SSL) enables learning useful inductive biases through utilizing pretext tasks that require no labels. The unlabeled nature of SSL makes it especially important for whole slide histopathological images (WSIs), where…

Computer Vision and Pattern Recognition · Computer Science 2022-11-15 Wisdom Oluchi Ikezogwo , Mehmet Saygin Seyfioglu , Linda Shapiro

Variational Autoencoders (VAEs) have become a popular approach for dimensionality reduction. However, despite their ability to identify latent low-dimensional structures embedded within high-dimensional data, these latent representations…

Machine Learning · Statistics 2020-08-27 Kaspar Märtens , Christopher Yau

Vision-language models encode images and text in a joint space, minimizing the distance between corresponding image and text pairs. How are language and images organized in this joint space, and how do the models encode meaning and…

Computer Vision and Pattern Recognition · Computer Science 2025-08-25 Isabel Papadimitriou , Huangyuan Su , Thomas Fel , Sham Kakade , Stephanie Gil

The electrocardiogram (ECG) is an inexpensive and widely available tool for cardiovascular assessment. Despite its standardized format and small file size, the high complexity and inter-individual variability of ECG signals (typically a…

Machine Learning · Computer Science 2024-10-31 Christopher J. Harvey , Sumaiya Shomaji , Zijun Yao , Amit Noheria

Automated computational analysis of the vast chemical space is critical for numerous fields of research such as drug discovery and material science. Representation learning techniques have recently been employed with the primary objective…

Quantitative Methods · Quantitative Biology 2023-05-26 Atakan Yüksel , Erva Ulusoy , Atabey Ünlü , Tunca Doğan

By composing graphical models with deep learning architectures, we learn generative models with the strengths of both frameworks. The structured variational autoencoder (SVAE) inherits structure and interpretability from graphical models,…

Machine Learning · Computer Science 2023-11-15 Harry Bendekgey , Gabriel Hope , Erik B. Sudderth